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  1. Increased epicardial adipose tissue thickness and plasma homocysteine levels are associated with Metabolic Syndrome (MS) and coronary artery disease. The majority of patients with MS have subclinical or manife...

    Authors: Akif Serhat Balcioğlu, Murtaza Emre Durakoğlugil, Davran Çiçek, Uğur Abbas Bal, Bülent Boyaci and Haldun Müderrisoğlu
    Citation: Diabetology & Metabolic Syndrome 2014 6:62
    Content type: Research Published on:

  2. There are a few nutritional approaches to address the increased needs of managing diabetic conditions. Previously it has been reported that UP780, a standardized composition of aloe chromone formulated with an...

    Authors: Mesfin Yimam, Jifu Zhao, Brandon Corneliusen, Mandee Pantier, Lidia Brownell and Qi Jia
    Citation: Diabetology & Metabolic Syndrome 2014 6:61
    Content type: Research Published on:

  3. There is a very well known correlation between diabetes and cardiovascular disease but many health care professionals are just concerned with glycemic control, ignoring the paramount importance of controlling ...

    Authors: Marcello Casaccia Bertoluci, Augusto Pimazoni-Netto, Antonio Carlos Pires, Antonio Eduardo Pesaro, Beatriz D Schaan, Bruno Caramelli, Carisi Anne Polanczyk, Carlos Vicente Serrano Júnior, Danielle M Gualandro, Domingos Augusto Malerbi, Emilio Moriguchi, Flavio Antonio de Oliveira Borelli, João Eduardo Nunes Salles, José Mariani Júnior, Luis Eduardo Rohde, Luis H Canani…
    Citation: Diabetology & Metabolic Syndrome 2014 6:58
    Content type: Review Published on:

  4. Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction...

    Authors: Erik Salum, Mark Butlin, Jaak Kals, Mihkel Zilmer, Jaan Eha, Alberto P Avolio, Andres Arend, Marina Aunapuu and Priit Kampus
    Citation: Diabetology & Metabolic Syndrome 2014 6:57
    Content type: Research Published on:

  5. Oxidized low-density lipoprotein (LDL) plays central roles in the formation and progression of atherosclerotic lesions. Malondialdehyde (MDA)-modified LDL (MDA-LDL) is speculated to be generated as a result of...

    Authors: Masami Tanaka, Risa Nishimura, Takeshi Nishimura, Toshihide Kawai, Shu Meguro, Junichiro Irie, Yoshifumi Saisho and Hiroshi Itoh
    Citation: Diabetology & Metabolic Syndrome 2014 6:56
    Content type: Research Published on:

  6. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Platelet-to-lymphocyte ratio (PLR) and neutrophil-...

    Authors: Emin M Akbas, Hikmet Hamur, Levent Demirtas, Eftal M Bakirci, Adalet Ozcicek, Fatih Ozcicek, Ufuk Kuyrukluyildiz and Kultigin Turkmen
    Citation: Diabetology & Metabolic Syndrome 2014 6:55
    Content type: Research Published on:

  7. Hemoglobin A1c is the main treatment target for patients with type 2 diabetes. It has also been shown recently that postprandial glucose and daily glucose fluctuations affect the progression of diabetic compli...

    Authors: Masahiro Yamazaki, Goji Hasegawa, Saori Majima, Kazuteru Mitsuhashi, Takuya Fukuda, Hiroya Iwase, Mayuko Kadono, Mai Asano, Takafumi Senmaru, Muhei Tanaka, Michiaki Fukui and Naoto Nakamura
    Citation: Diabetology & Metabolic Syndrome 2014 6:54
    Content type: Research Published on:

  8. The US Federal and Drug Administration (FDA) recently revised statin drug labels to include the information that increases in fasting serum glucose and glycated haemoglobin levels have been reported with the u...

    Authors: Su May Liew, Ping Yein Lee, Nik Sherina Hanafi, Chirk Jenn Ng, Stalia Siew Lee Wong, Yook Chin Chia, Pauline Siew Mei Lai, Nur Farhana Mohd Zaidi and Ee Ming Khoo
    Citation: Diabetology & Metabolic Syndrome 2014 6:53
    Content type: Research Published on:

  9. Post-transplant diabetes mellitus (PTDM) has been associated with an increased risk of cardiovascular disease (CVD) mortality following kidney transplantation, but the association between pre-diabetes (i.e. im...

    Authors: Andrea Viecelli, Hung T Do Nguyen, Kenneth Yong, Doris Chan, Gursharan Dogra, Germaine Wong and Wai H Lim
    Citation: Diabetology & Metabolic Syndrome 2014 6:52
    Content type: Research Published on:

  10. The vascular complications of outpatients with diabetes at ordinary hospitals vary. Ischemic heart disease is barely predictable after treatment using previously reported therapeutic indices. We developed a si...

    Authors: Tadafumi Kajimoto, Mami S Sawamura, Reiko D Hayashi, Takeshi Oya, Rieko A Hirao and Haruhiko Kouhara
    Citation: Diabetology & Metabolic Syndrome 2014 6:51
    Content type: Research Published on:

  11. Obesity is a known risk factor for type 2 diabetes (T2D). We conducted a case–control study to assess the association between body mass index (BMI) and the risk of being diagnosed with T2D in the United States.

    Authors: Michael L Ganz, Neil Wintfeld, Qian Li, Veronica Alas, Jakob Langer and Mette Hammer
    Citation: Diabetology & Metabolic Syndrome 2014 6:50
    Content type: Research Published on:

  12. Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammati...

    Authors: Ching-Jung Hsieh, Pei-Wen Wang and Tse-Ying Chen
    Citation: Diabetology & Metabolic Syndrome 2014 6:49
    Content type: Research Published on:

  13. Combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) is effective for the treatment of type 2 diabetes (T2DM) that cannot be adequately controlled using OHAs alone. Though basal ...

    Authors: Noriko Ihana, Tetsuro Tsujimoto, Ritsuko Yamamoto-Honda, Miyako Kishimoto, Hiroshi Kajio, Hiroshi Noto, Masafumi Kakei and Mitsuhiko Noda
    Citation: Diabetology & Metabolic Syndrome 2014 6:48
    Content type: Research Published on:

  14. The inappropriate secretion of adipocytokines plays a critical role in chronic inflammatory states associated with obesity-linked type 2 diabetes and atherosclerosis. The pleiotropic actions of simvastatin and...

    Authors: Adriana Ferreira Grosso, Sérgio Ferreira de Oliveira, Maria de Lourdes Higuchi, Desidério Favarato, Luís Alberto de Oliveira Dallan and Protásio Lemos da Luz
    Citation: Diabetology & Metabolic Syndrome 2014 6:47
    Content type: Research Published on:

  15. Coronary artery disease (CAD) is the leading cause of death among individuals with type 2 diabetes (T2DM). T2DM accelerates atherosclerosis alongside classical risk factors such as dyslipidemia and hypertensio...

    Authors: Célia Bittencourt, Valdecira M Piveta, Carolina SV Oliveira, Felipe Crispim, Deyse Meira, Pedro Saddi-Rosa, Fernando MA Giuffrida and André F Reis
    Citation: Diabetology & Metabolic Syndrome 2014 6:46
    Content type: Research Published on:

  16. Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. The available drugs are not suff...

    Authors: Bhagat Singh, Ganesh V Sangle, Jeya Murugan, Rinku Umrani, Subhasis Roy, Onkar Kulkarni, Arvind Semwal, MK Unnikrishnan and Mukul Jain
    Citation: Diabetology & Metabolic Syndrome 2014 6:45
    Content type: Research Published on:

  17. Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF pop...

    Authors: An LM Stevens, Dominique Hansen, Vincent Vandoren, Rob Westerlaken, An Creemers, Bert O Eijnde and Paul Dendale
    Citation: Diabetology & Metabolic Syndrome 2014 6:44
    Content type: Research Published on:

  18. There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this as...

    Authors: Francis M Finucane, Stephen J Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J Griffin and Nicholas J Wareham
    Citation: Diabetology & Metabolic Syndrome 2014 6:43
    Content type: Research Published on:

  19. The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal mo...

    Authors: Cristina Mega, Helena Vala, Paulo Rodrigues-Santos, Jorge Oliveira, Frederico Teixeira, Rosa Fernandes, Flávio Reis and Edite Teixeira de Lemos
    Citation: Diabetology & Metabolic Syndrome 2014 6:42
    Content type: Research Published on:

  20. To observe the efficacy and safety of adding glimepiride to established insulin therapy in poorly controlled type 2 diabetes (T2D) and to assess the relationship of changes in the serum high-molecular weight (...

    Authors: Chun-Jun Li, Jing-Yun Zhang, De-Min Yu and Qiu-Mei Zhang
    Citation: Diabetology & Metabolic Syndrome 2014 6:41
    Content type: Research Published on:

  21. To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body we...

    Authors: Petri K Wiklund, Satu Pekkala, Reija Autio, Eveliina Munukka, Leiting Xu, Juha Saltevo, ShuMei Cheng, Urho M Kujala, Markku Alen and Sulin Cheng
    Citation: Diabetology & Metabolic Syndrome 2014 6:40
    Content type: Research Published on:

  22. Both low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), ...

    Authors: Lena M Håglin, Birgitta Törnkvist and Lennart O Bäckman
    Citation: Diabetology & Metabolic Syndrome 2014 6:39
    Content type: Research Published on:

  23. The frequency of Type 1 diabetes (T1D)-related autoantibodies was determined in children with autoimmune hepatitis. However, the incidence of autoimmune hepatitis related autoantibodies in children with T1D ha...

    Authors: Abdulrahman A Al-Hussaini, Musa D Alzahrani, Ahmed S Alenizi, Nimer M Suliman, Mannan A Khan, Sahar A Alharbi and Aziz A Chentoufi
    Citation: Diabetology & Metabolic Syndrome 2014 6:38
    Content type: Research Published on:

  24. Premixed insulin regimens are commonly used for the treatment of patients with type-2 diabetes mellitus (T2DM). However, limited data are available regarding next-step therapy options in cases where premixed i...

    Authors: Ying Zhang, Yi-juan Xie, Dong-dong Meng, Hao-hang Zhang, Hui Chen and En Liu
    Citation: Diabetology & Metabolic Syndrome 2014 6:37
    Content type: Research Published on:

  25. Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise...

    Authors: Rune Byrkjeland, Elisabeth Edvardsen, Ida Unhammer Njerve, Harald Arnesen, Ingebjørg Seljeflot and Svein Solheim
    Citation: Diabetology & Metabolic Syndrome 2014 6:36
    Content type: Research Published on:

  26. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is currently used to achieve glycemic targets in patients with type 2 diabetes mellitus (T2DM). The addition of DPP-4 inhibitors to ongoing insulin ther...

    Authors: Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Tomio Onuma, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Kazunari Matsumoto, Hiroki Yokoyama, Mamiko Tsugawa, Masahiko Gosho, Iichiro Shimomura…
    Citation: Diabetology & Metabolic Syndrome 2014 6:35
    Content type: Research Published on:

  27. Stem cell therapy holds a great promise for the repair of injured tissues and organs, including the kidney. We studied the effect of mesenchymal stem cells (MSC) on experimental diabetic nephropathy (DN) in ra...

    Authors: Mohamed Talaat Abdel Aziz, Mohamed Abdel Aziz Wassef, Hanan Hosni Ahmed, Laila Rashed, Soheir Mahfouz, Mayssa Ibrahim Aly, Rania Elsayed Hussein and Mai Abdelaziz
    Citation: Diabetology & Metabolic Syndrome 2014 6:34
    Content type: Research Published on:

  28. Although several studies showed that decreased soluble receptor for advanced glycation end products (sRAGE) is associated with metabolic syndrome (MetS), inflammation level has not been considered, even though...

    Authors: Haruki Momma, Kaijun Niu, Yoritoshi Kobayashi, Cong Huang, Masahiko Chujo, Atsushi Otomo, Hiroko Tadaura, Toshio Miyata and Ryoichi Nagatomi
    Citation: Diabetology & Metabolic Syndrome 2014 6:33
    Content type: Research Published on:

  29. The incidence of macrovascular complications and morbidities associated to metabolic syndrome are increasing in patients with type 1 diabetes mellitus (T1DM). The combination of T1DM with features of insulin r...

    Authors: Aldo Ferreira-Hermosillo, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta and Mario A Molina-Ayala
    Citation: Diabetology & Metabolic Syndrome 2014 6:32
    Content type: Research Published on:

  30. The recent Latin American and European guidelines published this year has proposed as a goal for blood pressure control in patients with diabetes type 2 a value similar or inferior to 140/90 mmHg. High blood p...

    Authors: Patricio Lopez-Jaramillo, Jose Lopez-Lopez, Cristina Lopez-Lopez and Miguel I Rodriguez-Alvarez
    Citation: Diabetology & Metabolic Syndrome 2014 6:31
    Content type: Review Published on:

  31. Fenofibrate offers a number of benefits on the cardiovascular system and it is plausible that its anti-inflammatory, anti-oxidant and anti-fibrotic effects and enhancement of cardiac metabolic performances may...

    Authors: Cristina Nita, Cornelia Bala, Mihai Porojan and Nicolae Hancu
    Citation: Diabetology & Metabolic Syndrome 2014 6:30
    Content type: Research Published on:

  32. This study investigated the effect of exenatide on the cardiac expression of adiponectin receptor 1 and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits and heart function in streptozotocin...

    Authors: Zhixin Guo, Wei Qi, Yuanxian Yu, Shijing Du, Jieping Wu and Jinjin Liu
    Citation: Diabetology & Metabolic Syndrome 2014 6:29
    Content type: Research Published on:

  33. The aim of our study was to evaluate the associations between arterial stiffness indexes and immune-inflammatory markers in subjects with acute ischemic stroke with and without metabolic syndrome.

    Authors: Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Riccardo Di Sciacca, Baldassare Canino, Valentina Arnao, Carmelo Buttà, Vittoriano Della Corte, Carlo Maida, Giuseppe Licata and Antonio Pinto
    Citation: Diabetology & Metabolic Syndrome 2014 6:28
    Content type: Research Published on:

  34. A high-calorie diet and physical inactivity, an imbalance between caloric intake and energy consumption, are major causes of metabolic syndrome (MetS), which manifests as accumulation of visceral fat and insul...

    Authors: Shusuke Yagi, Muneyuki Kadota, Ken-ichi Aihara, Koji Nishikawa, Tomoya Hara, Takayuki Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Michio Shimabukuro, Shinsuke Katoh and Masataka Sata
    Citation: Diabetology & Metabolic Syndrome 2014 6:27
    Content type: Research Published on:

  35. Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels ma...

    Authors: Anize D von Frankenberg, Filipe V do Nascimento, Lucas Eduardo Gatelli, Bárbara L Nedel, Sheila P Garcia, Carolina SV de Oliveira, Pedro Saddi-Rosa, André F Reis, Luis H Canani and Fernando Gerchman
    Citation: Diabetology & Metabolic Syndrome 2014 6:26
    Content type: Research Published on:

  36. Retinol-binding protein 4 (RBP4), a novel adipokine secreted by adipocytes and the liver, has elevated levels in type 2 diabetes mellitus (T2DM). However, its association with human metabolic diseases remains ...

    Authors: Yan Liu, Duan Wang, Di Li, Ruifang Sun and Min Xia
    Citation: Diabetology & Metabolic Syndrome 2014 6:25
    Content type: Research Published on:

  37. Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data fro...

    Authors: Michel M Joosten, Ilse C Schrieks and Henk FJ Hendriks
    Citation: Diabetology & Metabolic Syndrome 2014 6:24
    Content type: Research Published on:

  38. Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk of heart disease, stroke and diabetes. Since pathways implicated in different diseases reveal surprising insights i...

    Authors: Vânia Gaio, Baltazar Nunes, Aida Fernandes, Francisco Mendonça, Filomena Horta Correia, Álvaro Beleza, Ana Paula Gil, Mafalda Bourbon, Astrid Vicente, Carlos Matias Dias and Marta Barreto da Silva
    Citation: Diabetology & Metabolic Syndrome 2014 6:23
    Content type: Research Published on:

  39. Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This stud...

    Authors: Luciana Dias Folchetti, Milena Monfort-Pires, Camila R de Barros, Lígia Araújo Martini and Sandra Roberta Gouvea Ferreira
    Citation: Diabetology & Metabolic Syndrome 2014 6:22
    Content type: Research Published on:

  40. Diabetes mellitus (DM) and intermittent claudication (IC) are frequently associated health conditions. Our hypothesis is that the nature, severity and quality of life (QoL) of patients with IC and DM are worse...

    Authors: Francisco S Lozano, José R González-Porras, José R March, José M Lobos, Eduardo Carrasco and Eduardo Ros
    Citation: Diabetology & Metabolic Syndrome 2014 6:21
    Content type: Research Published on:

  41. A dd-on L antus® to O ral H ypoglycemic A gents (ALOHA), an observational, non-interventional, 24-week post-marketing surveillance study in Japanese patients with type 2 diabetes (T2DM) having uncontrolled glycem...

    Authors: Masato Odawara, Takashi Kadowaki and Yusuke Naito
    Citation: Diabetology & Metabolic Syndrome 2014 6:20
    Content type: Research Published on:

  42. The relationship of saliva with plasma protein levels makes saliva an attractive diagnostic tool. Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previous...

    Authors: Supanee Thanakun, Hisashi Watanabe, Sroisiri Thaweboon and Yuichi Izumi
    Citation: Diabetology & Metabolic Syndrome 2014 6:19
    Content type: Research Published on:

  43. Obesity, a critical component of metabolic syndrome (MetS), is associated with depression. Deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. We hypothesized tha...

    Authors: I-Te Lee, Chia-Po Fu, Wen-Jane Lee, Kae-Woei Liang, Shih-Yi Lin, Chu-Jen Wan and Wayne Huey-Herng Sheu
    Citation: Diabetology & Metabolic Syndrome 2014 6:18
    Content type: Research Published on:

  44. About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephro...

    Authors: Bruno Schmidt Dellamea, Cristiane Bauermann Leitão, Rogério Friedman and Luis Henrique Canani
    Citation: Diabetology & Metabolic Syndrome 2014 6:17
    Content type: Review Published on:

  45. Glycated hemoglobin (A1C) and Fasting Plasma Glucose (FPG) are the two monitoring blood glucose tests most frequently used. However, both methods are shown to be insensitive to detect glycemic variations in sh...

    Authors: Bruno P Moura, Paulo RS Amorim, Bruno PP Silva, Sylvia CC Franceschini, Janice S Reis and João CB Marins
    Citation: Diabetology & Metabolic Syndrome 2014 6:16
    Content type: Research Published on:

  46. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) was lower in the general population with metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between MetS and fasting s...

    Authors: Ji-Hung Wang, Chung-Jen Lee, Jen-Che Hsieh, Yu-Chih Chen and Bang-Gee Hsu
    Citation: Diabetology & Metabolic Syndrome 2014 6:15
    Content type: Research Published on:

  48. Individuals with diabetes may develop cardiac autonomic dysfunction that may be evaluated by heart rate variability (HRV). The aim was evaluated heart rate variability (HRV) of individuals with type 2 diabetes...

    Authors: Sílvia CG Moura-Tonello, Anielle CM Takahashi, Cristina O Francisco, Sérgio LB Lopes, Adriano M Del Vale, Audrey Borghi-Silva, Angela MO Leal, Nicola Montano, Alberto Porta and Aparecida M Catai
    Citation: Diabetology & Metabolic Syndrome 2014 6:13
    Content type: Research Published on:

  50. The Editors of Diabetology and Metabolic Syndrome would like to thank all our reviewers who have contributed to the journal in Volume 5 (2013).

    Authors: Daniel Giannella-Neto and Marilia de Brito Gomes
    Citation: Diabetology & Metabolic Syndrome 2014 6:9
    Content type: Reviewer acknowledgement Published on:

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Diabetology & Metabolic Syndrome

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