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  1. Post-transplant diabetes mellitus (PTDM) has been associated with an increased risk of cardiovascular disease (CVD) mortality following kidney transplantation, but the association between pre-diabetes (i.e. im...

    Authors: Andrea Viecelli, Hung T Do Nguyen, Kenneth Yong, Doris Chan, Gursharan Dogra, Germaine Wong and Wai H Lim

    Citation: Diabetology & Metabolic Syndrome 2014 6:52

    Content type: Research

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  2. The vascular complications of outpatients with diabetes at ordinary hospitals vary. Ischemic heart disease is barely predictable after treatment using previously reported therapeutic indices. We developed a si...

    Authors: Tadafumi Kajimoto, Mami S Sawamura, Reiko D Hayashi, Takeshi Oya, Rieko A Hirao and Haruhiko Kouhara

    Citation: Diabetology & Metabolic Syndrome 2014 6:51

    Content type: Research

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  3. Obesity is a known risk factor for type 2 diabetes (T2D). We conducted a case–control study to assess the association between body mass index (BMI) and the risk of being diagnosed with T2D in the United States.

    Authors: Michael L Ganz, Neil Wintfeld, Qian Li, Veronica Alas, Jakob Langer and Mette Hammer

    Citation: Diabetology & Metabolic Syndrome 2014 6:50

    Content type: Research

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  4. Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammati...

    Authors: Ching-Jung Hsieh, Pei-Wen Wang and Tse-Ying Chen

    Citation: Diabetology & Metabolic Syndrome 2014 6:49

    Content type: Research

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  5. Combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) is effective for the treatment of type 2 diabetes (T2DM) that cannot be adequately controlled using OHAs alone. Though basal ...

    Authors: Noriko Ihana, Tetsuro Tsujimoto, Ritsuko Yamamoto-Honda, Miyako Kishimoto, Hiroshi Kajio, Hiroshi Noto, Masafumi Kakei and Mitsuhiko Noda

    Citation: Diabetology & Metabolic Syndrome 2014 6:48

    Content type: Research

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  6. The inappropriate secretion of adipocytokines plays a critical role in chronic inflammatory states associated with obesity-linked type 2 diabetes and atherosclerosis. The pleiotropic actions of simvastatin and...

    Authors: Adriana Ferreira Grosso, Sérgio Ferreira de Oliveira, Maria de Lourdes Higuchi, Desidério Favarato, Luís Alberto de Oliveira Dallan and Protásio Lemos da Luz

    Citation: Diabetology & Metabolic Syndrome 2014 6:47

    Content type: Research

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  7. Coronary artery disease (CAD) is the leading cause of death among individuals with type 2 diabetes (T2DM). T2DM accelerates atherosclerosis alongside classical risk factors such as dyslipidemia and hypertensio...

    Authors: Célia Bittencourt, Valdecira M Piveta, Carolina SV Oliveira, Felipe Crispim, Deyse Meira, Pedro Saddi-Rosa, Fernando MA Giuffrida and André F Reis

    Citation: Diabetology & Metabolic Syndrome 2014 6:46

    Content type: Research

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  8. Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. The available drugs are not suff...

    Authors: Bhagat Singh, Ganesh V Sangle, Jeya Murugan, Rinku Umrani, Subhasis Roy, Onkar Kulkarni, Arvind Semwal, MK Unnikrishnan and Mukul Jain

    Citation: Diabetology & Metabolic Syndrome 2014 6:45

    Content type: Research

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  9. Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF pop...

    Authors: An LM Stevens, Dominique Hansen, Vincent Vandoren, Rob Westerlaken, An Creemers, Bert O Eijnde and Paul Dendale

    Citation: Diabetology & Metabolic Syndrome 2014 6:44

    Content type: Research

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  10. There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this as...

    Authors: Francis M Finucane, Stephen J Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J Griffin and Nicholas J Wareham

    Citation: Diabetology & Metabolic Syndrome 2014 6:43

    Content type: Research

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  11. The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal mo...

    Authors: Cristina Mega, Helena Vala, Paulo Rodrigues-Santos, Jorge Oliveira, Frederico Teixeira, Rosa Fernandes, Flávio Reis and Edite Teixeira de Lemos

    Citation: Diabetology & Metabolic Syndrome 2014 6:42

    Content type: Research

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  12. To observe the efficacy and safety of adding glimepiride to established insulin therapy in poorly controlled type 2 diabetes (T2D) and to assess the relationship of changes in the serum high-molecular weight (...

    Authors: Chun-Jun Li, Jing-Yun Zhang, De-Min Yu and Qiu-Mei Zhang

    Citation: Diabetology & Metabolic Syndrome 2014 6:41

    Content type: Research

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  13. To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body we...

    Authors: Petri K Wiklund, Satu Pekkala, Reija Autio, Eveliina Munukka, Leiting Xu, Juha Saltevo, ShuMei Cheng, Urho M Kujala, Markku Alen and Sulin Cheng

    Citation: Diabetology & Metabolic Syndrome 2014 6:40

    Content type: Research

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  14. Both low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), ...

    Authors: Lena M Håglin, Birgitta Törnkvist and Lennart O Bäckman

    Citation: Diabetology & Metabolic Syndrome 2014 6:39

    Content type: Research

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  15. The frequency of Type 1 diabetes (T1D)-related autoantibodies was determined in children with autoimmune hepatitis. However, the incidence of autoimmune hepatitis related autoantibodies in children with T1D ha...

    Authors: Abdulrahman A Al-Hussaini, Musa D Alzahrani, Ahmed S Alenizi, Nimer M Suliman, Mannan A Khan, Sahar A Alharbi and Aziz A Chentoufi

    Citation: Diabetology & Metabolic Syndrome 2014 6:38

    Content type: Research

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  16. Premixed insulin regimens are commonly used for the treatment of patients with type-2 diabetes mellitus (T2DM). However, limited data are available regarding next-step therapy options in cases where premixed i...

    Authors: Ying Zhang, Yi-juan Xie, Dong-dong Meng, Hao-hang Zhang, Hui Chen and En Liu

    Citation: Diabetology & Metabolic Syndrome 2014 6:37

    Content type: Research

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  17. Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise...

    Authors: Rune Byrkjeland, Elisabeth Edvardsen, Ida Unhammer Njerve, Harald Arnesen, Ingebjørg Seljeflot and Svein Solheim

    Citation: Diabetology & Metabolic Syndrome 2014 6:36

    Content type: Research

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  18. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is currently used to achieve glycemic targets in patients with type 2 diabetes mellitus (T2DM). The addition of DPP-4 inhibitors to ongoing insulin ther...

    Authors: Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Tomio Onuma, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Kazunari Matsumoto, Hiroki Yokoyama, Mamiko Tsugawa, Masahiko Gosho, Iichiro Shimomura…

    Citation: Diabetology & Metabolic Syndrome 2014 6:35

    Content type: Research

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  19. Stem cell therapy holds a great promise for the repair of injured tissues and organs, including the kidney. We studied the effect of mesenchymal stem cells (MSC) on experimental diabetic nephropathy (DN) in ra...

    Authors: Mohamed Talaat Abdel Aziz, Mohamed Abdel Aziz Wassef, Hanan Hosni Ahmed, Laila Rashed, Soheir Mahfouz, Mayssa Ibrahim Aly, Rania Elsayed Hussein and Mai Abdelaziz

    Citation: Diabetology & Metabolic Syndrome 2014 6:34

    Content type: Research

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  20. Although several studies showed that decreased soluble receptor for advanced glycation end products (sRAGE) is associated with metabolic syndrome (MetS), inflammation level has not been considered, even though...

    Authors: Haruki Momma, Kaijun Niu, Yoritoshi Kobayashi, Cong Huang, Masahiko Chujo, Atsushi Otomo, Hiroko Tadaura, Toshio Miyata and Ryoichi Nagatomi

    Citation: Diabetology & Metabolic Syndrome 2014 6:33

    Content type: Research

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  21. The incidence of macrovascular complications and morbidities associated to metabolic syndrome are increasing in patients with type 1 diabetes mellitus (T1DM). The combination of T1DM with features of insulin r...

    Authors: Aldo Ferreira-Hermosillo, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta and Mario A Molina-Ayala

    Citation: Diabetology & Metabolic Syndrome 2014 6:32

    Content type: Research

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  22. The recent Latin American and European guidelines published this year has proposed as a goal for blood pressure control in patients with diabetes type 2 a value similar or inferior to 140/90 mmHg. High blood p...

    Authors: Patricio Lopez-Jaramillo, Jose Lopez-Lopez, Cristina Lopez-Lopez and Miguel I Rodriguez-Alvarez

    Citation: Diabetology & Metabolic Syndrome 2014 6:31

    Content type: Review

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  23. Fenofibrate offers a number of benefits on the cardiovascular system and it is plausible that its anti-inflammatory, anti-oxidant and anti-fibrotic effects and enhancement of cardiac metabolic performances may...

    Authors: Cristina Nita, Cornelia Bala, Mihai Porojan and Nicolae Hancu

    Citation: Diabetology & Metabolic Syndrome 2014 6:30

    Content type: Research

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  24. This study investigated the effect of exenatide on the cardiac expression of adiponectin receptor 1 and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits and heart function in streptozotocin...

    Authors: Zhixin Guo, Wei Qi, Yuanxian Yu, Shijing Du, Jieping Wu and Jinjin Liu

    Citation: Diabetology & Metabolic Syndrome 2014 6:29

    Content type: Research

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  25. The aim of our study was to evaluate the associations between arterial stiffness indexes and immune-inflammatory markers in subjects with acute ischemic stroke with and without metabolic syndrome.

    Authors: Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Riccardo Di Sciacca, Baldassare Canino, Valentina Arnao, Carmelo Buttà, Vittoriano Della Corte, Carlo Maida, Giuseppe Licata and Antonio Pinto

    Citation: Diabetology & Metabolic Syndrome 2014 6:28

    Content type: Research

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  26. A high-calorie diet and physical inactivity, an imbalance between caloric intake and energy consumption, are major causes of metabolic syndrome (MetS), which manifests as accumulation of visceral fat and insul...

    Authors: Shusuke Yagi, Muneyuki Kadota, Ken-ichi Aihara, Koji Nishikawa, Tomoya Hara, Takayuki Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Michio Shimabukuro, Shinsuke Katoh and Masataka Sata

    Citation: Diabetology & Metabolic Syndrome 2014 6:27

    Content type: Research

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  27. Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels ma...

    Authors: Anize D von Frankenberg, Filipe V do Nascimento, Lucas Eduardo Gatelli, Bárbara L Nedel, Sheila P Garcia, Carolina SV de Oliveira, Pedro Saddi-Rosa, André F Reis, Luis H Canani and Fernando Gerchman

    Citation: Diabetology & Metabolic Syndrome 2014 6:26

    Content type: Research

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  28. Retinol-binding protein 4 (RBP4), a novel adipokine secreted by adipocytes and the liver, has elevated levels in type 2 diabetes mellitus (T2DM). However, its association with human metabolic diseases remains ...

    Authors: Yan Liu, Duan Wang, Di Li, Ruifang Sun and Min Xia

    Citation: Diabetology & Metabolic Syndrome 2014 6:25

    Content type: Research

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  29. Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data fro...

    Authors: Michel M Joosten, Ilse C Schrieks and Henk FJ Hendriks

    Citation: Diabetology & Metabolic Syndrome 2014 6:24

    Content type: Research

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  30. Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk of heart disease, stroke and diabetes. Since pathways implicated in different diseases reveal surprising insights i...

    Authors: Vânia Gaio, Baltazar Nunes, Aida Fernandes, Francisco Mendonça, Filomena Horta Correia, Álvaro Beleza, Ana Paula Gil, Mafalda Bourbon, Astrid Vicente, Carlos Matias Dias and Marta Barreto da Silva

    Citation: Diabetology & Metabolic Syndrome 2014 6:23

    Content type: Research

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  31. Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This stud...

    Authors: Luciana Dias Folchetti, Milena Monfort-Pires, Camila R de Barros, Lígia Araújo Martini and Sandra Roberta Gouvea Ferreira

    Citation: Diabetology & Metabolic Syndrome 2014 6:22

    Content type: Research

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  32. Diabetes mellitus (DM) and intermittent claudication (IC) are frequently associated health conditions. Our hypothesis is that the nature, severity and quality of life (QoL) of patients with IC and DM are worse...

    Authors: Francisco S Lozano, José R González-Porras, José R March, José M Lobos, Eduardo Carrasco and Eduardo Ros

    Citation: Diabetology & Metabolic Syndrome 2014 6:21

    Content type: Research

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  33. A dd-on L antus® to O ral H ypoglycemic A gents (ALOHA), an observational, non-interventional, 24-week post-marketing surveillance study in Japanese patients with type 2 diabetes (T2DM) having uncontrolled glycem...

    Authors: Masato Odawara, Takashi Kadowaki and Yusuke Naito

    Citation: Diabetology & Metabolic Syndrome 2014 6:20

    Content type: Research

    Published on:

  34. The relationship of saliva with plasma protein levels makes saliva an attractive diagnostic tool. Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previous...

    Authors: Supanee Thanakun, Hisashi Watanabe, Sroisiri Thaweboon and Yuichi Izumi

    Citation: Diabetology & Metabolic Syndrome 2014 6:19

    Content type: Research

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  35. Obesity, a critical component of metabolic syndrome (MetS), is associated with depression. Deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. We hypothesized tha...

    Authors: I-Te Lee, Chia-Po Fu, Wen-Jane Lee, Kae-Woei Liang, Shih-Yi Lin, Chu-Jen Wan and Wayne Huey-Herng Sheu

    Citation: Diabetology & Metabolic Syndrome 2014 6:18

    Content type: Research

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  36. About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephro...

    Authors: Bruno Schmidt Dellamea, Cristiane Bauermann Leitão, Rogério Friedman and Luis Henrique Canani

    Citation: Diabetology & Metabolic Syndrome 2014 6:17

    Content type: Review

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  37. Glycated hemoglobin (A1C) and Fasting Plasma Glucose (FPG) are the two monitoring blood glucose tests most frequently used. However, both methods are shown to be insensitive to detect glycemic variations in sh...

    Authors: Bruno P Moura, Paulo RS Amorim, Bruno PP Silva, Sylvia CC Franceschini, Janice S Reis and João CB Marins

    Citation: Diabetology & Metabolic Syndrome 2014 6:16

    Content type: Research

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  38. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) was lower in the general population with metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between MetS and fasting s...

    Authors: Ji-Hung Wang, Chung-Jen Lee, Jen-Che Hsieh, Yu-Chih Chen and Bang-Gee Hsu

    Citation: Diabetology & Metabolic Syndrome 2014 6:15

    Content type: Research

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  39. Individuals with diabetes may develop cardiac autonomic dysfunction that may be evaluated by heart rate variability (HRV). The aim was evaluated heart rate variability (HRV) of individuals with type 2 diabetes...

    Authors: Sílvia CG Moura-Tonello, Anielle CM Takahashi, Cristina O Francisco, Sérgio LB Lopes, Adriano M Del Vale, Audrey Borghi-Silva, Angela MO Leal, Nicola Montano, Alberto Porta and Aparecida M Catai

    Citation: Diabetology & Metabolic Syndrome 2014 6:13

    Content type: Research

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  40. Waist circumference (WC) is used as a risk assessment for metabolic syndrome, diabetes, and cardiovascular disease (CVD). WC consists of visceral fat area (VFA), subcutaneous fat area (SFA), muscle, intramuscu...

    Authors: Yumi Matsushita, Toru Nakagawa, Michihiro Shinohara, Shuichiro Yamamoto, Yoshihiko Takahashi, Tetsuya Mizoue, Tetsuji Yokoyama and Mitsuhiko Noda

    Citation: Diabetology & Metabolic Syndrome 2014 6:11

    Content type: Research

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  41. The Editors of Diabetology and Metabolic Syndrome would like to thank all our reviewers who have contributed to the journal in Volume 5 (2013).

    Authors: Daniel Giannella-Neto and Marilia de Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2014 6:9

    Content type: Reviewer acknowledgement

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  42. The obese Zücker diabetic fatty male rat (ZDF:Gmi™-fa) is an animal model of type II diabetes associated with obesity and related metabolic disturbances like dyslipidaemia and diabetic nephropathy. In addition...

    Authors: Eduardo J Lezcano, Pablo Iñigo, Ana M Larraga, Cristina Barranquero, Ignacio Gimenez and Jesús Osada

    Citation: Diabetology & Metabolic Syndrome 2014 6:10

    Content type: Research

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  43. The etiology of the metabolic syndrome is complex, and is determined by the interplay of both genetic and environmental factors. The present study was designed to identify genes and proteins in the adipose tis...

    Authors: Jie Chang, Shinji Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda, Chieko Aoki, Yoshiji Yamada, Gaku Ichihara, Masashi Kato and Sahoko Ichihara

    Citation: Diabetology & Metabolic Syndrome 2014 6:8

    Content type: Research

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  44. Vitamin D deficiency has been linked to several cardiovascular risk factors but information regarding vitamin D concentrations in familial combined hyperlipidemia (FCHL) is lacking. Our objective was to examin...

    Authors: Inka Miñambres, Jose Luis Sánchez-Quesada, Joan Sánchez-Hernández, Jose Rodríguez, Alberto de Leiva and Antonio Pérez

    Citation: Diabetology & Metabolic Syndrome 2014 6:7

    Content type: Research

    Published on:

  45. Metabolic syndrome is a cluster of metabolic risk factors including dyslipidemia, impaired glucose tolerance, hypertension and central obesity. BDNF (Brain-derived neurotrophic factor) and leptin have been imp...

    Authors: Kanjana Suriyaprom, Rungsunn Tungtrongchitr and Kittisak Thawnasom

    Citation: Diabetology & Metabolic Syndrome 2014 6:6

    Content type: Research

    Published on:

  46. Type 2 diabetes mellitus patients with an acute coronary event (ACE) experience decreased quality of life and increased distress. According to the American Diabetes Association, discharge from the hospital is ...

    Authors: Marise J Kasteleyn, Kees J Gorter, Rebecca K Stellato, Mieke Rijken, Giel Nijpels and Guy EHM Rutten

    Citation: Diabetology & Metabolic Syndrome 2014 6:5

    Content type: Research

    Published on:

  47. Dysregulation of omentin-1, a beneficial adipokine, is thought to play a role in the development of type 2 diabetes and cardiovascular disease. The objective of this study was to evaluate the relationship betw...

    Authors: Anh Vu, Maha S Sidhom, Brooke C Bredbeck, Lisa A Kosmiski and Christina L Aquilante

    Citation: Diabetology & Metabolic Syndrome 2014 6:4

    Content type: Research

    Published on:

  48. Glucocorticoid excess is commonly associated with diabetogenic effects, including insulin resistance and glucose intolerance. The effects of the long-term glucagon-like peptide 1 receptor agonist treatment on ...

    Authors: Liselotte Fransson, Cristiane dos Santos, Petra Wolbert, Åke Sjöholm, Alex Rafacho and Henrik Ortsäter

    Citation: Diabetology & Metabolic Syndrome 2014 6:3

    Content type: Research

    Published on:


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