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  1. The hypertensive, pro-inflammatory, obese state is strongly coupled to peripheral and hepatic insulin resistance (in composite termed metabolic syndrome [MS]). Hepatic pro-inflammatory pathways have been demon...

    Authors: Michael Ezrokhi, Shuqin Luo, Yelena Trubitsyna and Anthony H Cincotta
    Citation: Diabetology & Metabolic Syndrome 2014 6:104
    Content type: Research Published on:

    The Erratum to this article has been published in Diabetology & Metabolic Syndrome 2015 7:61

  2. Blood glucose control is fundamental albeit not enough to prevent diabetic macrovascular complications. Dipeptidyl peptidase-4 (DPP-4) inhibitors are effective in improving metabolic parameters in patients wit...

    Authors: Katia Camarano Nogueira, Meive Furtado, Rosa Tsuneshiro Fukui, Marcia Regina Silva Correia, Rosa Ferreira dos Santos, José Lázaro Andrade and Maria Elizabeth Rossi da Silva
    Citation: Diabetology & Metabolic Syndrome 2014 6:103
    Content type: Research Published on:

  3. Atorvastatin can downregulate the expression of receptor for advanced glycation end products (RAGE) in the aortas of diabetic rats. However, its effect on healthy rats remains unclear. The aim of this study wa...

    Authors: Lei Xu, Panpan Zang, Bo Feng and Qiaohui Qian
    Citation: Diabetology & Metabolic Syndrome 2014 6:102
    Content type: Research Published on:

  4. PPARγ is a member of the nuclear hormone receptor superfamily. It has been considered as a mediator regulating metabolism, anti-inflammation, and pro-proliferation in the Vascular Smooth Muscle Cells (VSMCs). ...

    Authors: Jing Wan, Zhichao Xiao, Shengping Chao, Shixi Xiong, Xuedong Gan, Xuguang Qiu, Chang Xu, Yexin Ma and Xin Tu
    Citation: Diabetology & Metabolic Syndrome 2014 6:101
    Content type: Research Published on:

  5. Adolescence, due to transient pubertal insulin resistance (IR), is associated with a higher risk for disturbances of glucose metabolism. The aim of our study was 1) to investigate the prevalence of disturbance...

    Authors: Irena Aldhoon-Hainerová, Hana Zamrazilová, Lenka Dušátková, Barbora Sedláčková, Petr Hlavatý, Martin Hill, Richard Hampl, Marie Kunešová and Vojtěch Hainer
    Citation: Diabetology & Metabolic Syndrome 2014 6:100
    Content type: Research Published on:

  6. Alterations in plasma adipokines and/or inflammatory parameters in Type 2 DM remain vague as to whether they are due to obesity and/or directly associated with the diabetic state. Our objective was to compare ...

    Authors: Zaid Al-Hamodi, Molham AL-Habori, Ali Al-Meeri and Riyadh Saif-Ali
    Citation: Diabetology & Metabolic Syndrome 2014 6:99
    Content type: Research Published on:

  7. Patients with either diabetes mellitus (DM) or metabolic syndrome (MS) are recognized as a high risk group for cardiovascular disease (CVD). Several studies have demonstrated the clinical value of MS for predi...

    Authors: Sang Youl Rhee, So Young Park, Jin Kyung Hwang, Jung Il Son, Sang Ouk Chin, Young Seol Kim and Jeong-taek Woo
    Citation: Diabetology & Metabolic Syndrome 2014 6:98
    Content type: Research Published on:

  8. Hypertension has been associated to diabetes, and participates in the development of diabetic complications. The spontaneously hypertensive rat (SHR) is the gold standard model for the study of hypertension, a...

    Authors: Ana Barbara Alves-Wagner, Robinson Sabino-Silva, Raquel S Campello, Rosana C Mori and Ubiratan F Machado
    Citation: Diabetology & Metabolic Syndrome 2014 6:97
    Content type: Short report Published on:

  9. Hemoglobin A1c (HbA1c) is the predominant diagnostic tool for diabetes diagnosis and progression. However, it has proven to be insensitive at pre-diabetic threshold values. O-linked-β-N-acetylglucosamine (O-GlcNA...

    Authors: Jason P Myslicki, Jane Shearer, Dustin S Hittel, Curtis C Hughey and Darrell D Belke
    Citation: Diabetology & Metabolic Syndrome 2014 6:96
    Content type: Short report Published on:

  10. Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been shown to possess pleiotropic effects including body weight reduction. However, long-term effect of liraglutide on body weight and glycemic cont...

    Authors: Kana Inoue, Norikazu Maeda, Yuya Fujishima, Shiro Fukuda, Hirofumi Nagao, Masaya Yamaoka, Ayumu Hirata, Hitoshi Nishizawa, Tohru Funahashi and Iichiro Shimomura
    Citation: Diabetology & Metabolic Syndrome 2014 6:95
    Content type: Research Published on:

  11. Oxidative modification of low density lipoproteins (LDL) convert these native particles into pathogenic, immunogenic and atherogenic particles. Factors enhance LDL oxidation are poorly understood, especially i...

    Authors: Essam Eldin Mohamed Nour Eldin, Abdullah Almarzouki, Adel Mohamed Assiri, Osman Mohammed Elsheikh, Badreldin Elsonni Abdalla Mohamed and Abdullatif Taha Babakr
    Citation: Diabetology & Metabolic Syndrome 2014 6:94
    Content type: Research Published on:

  12. Patients with metabolic syndrome (MS) often have increased platelet aggregation. In order to determine which concentration detects a higher level of platelet aggregation in patients with MS, the agonists ADP a...

    Authors: Laura Perez-Campos-Mayoral, Eduardo Pérez-Campos, Edgar Zenteno, Abraham Majluf-Cruz, Eduardo Perez-Ortega, Diana Matias-Pérez, Francisco J Rodal-Canales, Ruth Martínez-Cruz, Socorro Pina-Canseco, Miguel Angel Reyes Franco, Gabriel Mayoral Andrade, Pedro Hernández and Belem Gallegos
    Citation: Diabetology & Metabolic Syndrome 2014 6:93
    Content type: Research Published on:

  13. Several studies have reported that the metabolic syndrome (MS) is more common in subjects with HIV infection than in HIV-negative individuals. HIV infection and the use of Highly Active Antiretroviral Therapy ...

    Authors: Herbert Afegenwi Mbunkah, Henry Dilonga Meriki, Anthony Tufon Kukwah, Omarine Nfor and Theresa Nkuo-Akenji
    Citation: Diabetology & Metabolic Syndrome 2014 6:92
    Content type: Research Published on:

  14. The opposite effects of insulin and glucagon in fuel homeostasis, the paracrine/endocrine inhibitory effects of insulin on glucagon secretion and the hyperglucagonemia in the pathogenesis of type 2 diabetes (T...

    Authors: Amélio F Godoy-Matos
    Citation: Diabetology & Metabolic Syndrome 2014 6:91
    Content type: Review Published on:

  15. Aldosterone, a mineralocorticoid hormone produced at the adrenal glands, controls corporal hydroelectrolytic balance and, consequently, has a key role in blood pressure adjustments. Aldosterone also has direct...

    Authors: Thiago Bruder-Nascimento, Marcondes AB da Silva and Rita C Tostes
    Citation: Diabetology & Metabolic Syndrome 2014 6:90
    Content type: Review Published on:

  16. The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in...

    Authors: Michella Ghassibe-Sabbagh, Mary Deeb, Angelique K Salloum, Francis Mouzaya, Marc Haber, Yasser Al-Sarraj, Youssef Chami, Yasmine Akle, Kamal Hirbli, Rita Nemr, Rechdi Ahdab, Daniel E Platt, Antoine B Abchee, Hatem El-Shanti and Pierre A Zalloua
    Citation: Diabetology & Metabolic Syndrome 2014 6:89
    Content type: Research Published on:

  17. Diabetes and cerebral ischemic-reperfusion are among the most common causes of neurological complications in Egypt. The prevalence of diabetes in Egypt is high and it can be considered as a major clinical and ...

    Authors: Hoda E Mohamed, Sahar E El-Swefy, Rehab A Hasan and Ahmed A Hasan
    Citation: Diabetology & Metabolic Syndrome 2014 6:88
    Content type: Research Published on:

  18. Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective tr...

    Authors: Priscila Campos Sala, Raquel Susana Torrinhas, Daniel Giannella-Neto and Dan Linetzky Waitzberg
    Citation: Diabetology & Metabolic Syndrome 2014 6:87
    Content type: Review Published on:

  19. Advanced glycation end products (AGE)-receptor for AGE (RAGE) axis and renin-angiotensin system (RAS) play a role in diabetic nephropathy (DN). Matrix metalloproteinase-2 (MMP-2) activation also contributes to...

    Authors: Kei Fukami, Sho-ichi Yamagishi, Melinda T Coughlan, Brooke E Harcourt, Phillip Kantharidis, Vicki Thallas-Bonke, Seiya Okuda, Mark E Cooper and Josephine M Forbes
    Citation: Diabetology & Metabolic Syndrome 2014 6:86
    Content type: Research Published on:

  20. A low ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) is considered a risk factor for cardiovascular disease. Smoking is also a risk factor for cardiovascular disease even in an elderly population. ...

    Authors: Kenta Okada, Kazuhiko Kotani, Hiroaki Yagyu and Shun Ishibashi
    Citation: Diabetology & Metabolic Syndrome 2014 6:85
    Content type: Short report Published on:

  21. Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve ...

    Authors: Mayara Franzoi Moreno, Rachel De Laquila, Marcos Hiromu Okuda, Fábio Santos Lira, Gabriel Inácio de Morais Honorato de Souza, Cláudio Teodoro de Souza, Monica Marques Telles, Eliane Beraldi Ribeiro, Claudia Maria Oller do Nascimento and Lila Missae Oyama
    Citation: Diabetology & Metabolic Syndrome 2014 6:84
    Content type: Research Published on:

  22. In addition to their role in growth, cellular differentiation and homeostasis Retinoid X Receptors (RXR) regulate multiple physiological and metabolic pathways in various organs that have beneficial glucose an...

    Authors: Manoj Kumar Sadasivuni, Bobbili Madhusudhan Reddy, Jaideep Singh, Mammen O Anup, Venkategowda Sunil, Mudigere N Lakshmi, Sivakumaran Yogeshwari, Suni K Chacko, Talanki Lokesh Pooja, Anilkumar Dandu, Chandrashekaran Harish, Aralakuppe S Gopala, Shivakumar Pratibha, Baisani S Naveenkumar, Puttrevana M Pallavi, Mahesh Kumar Verma…
    Citation: Diabetology & Metabolic Syndrome 2014 6:83
    Content type: Research Published on:

  23. Cardiac autonomic neuropathy (CAN) is a common complication of type 2 diabetes mellitus (T2DM). Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of vascular damages. The goal o...

    Authors: Nan Wu, Xiaoling Cai, Kuanping Ye, Yintao Li, Min He, Weiwei Zhao and Renming Hu
    Citation: Diabetology & Metabolic Syndrome 2014 6:82
    Content type: Research Published on:

  25. Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced...

    Authors: Marilia Brito Gomes and Carlos Antonio Negrato
    Citation: Diabetology & Metabolic Syndrome 2014 6:80
    Content type: Research Published on:

  26. Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interac...

    Authors: Omar Jamal, Ehimen C Aneni, Sameer Shaharyar, Shozab S Ali, Don Parris, John W McEvoy, Emir Veledar, Michael J Blaha, Roger S Blumenthal, Arthur S Agatston, Raquel D Conceição, Theodore Feldman, Jose A Carvalho, Raul D Santos and Khurram Nasir
    Citation: Diabetology & Metabolic Syndrome 2014 6:79
    Content type: Research Published on:

  27. Low levels of serum 25–hydroxy vitamin D (25(OH)D), have been associated with development of type 2 diabetes and cardiovascular disease (CVD); however there are limited data on serum 25(OH)D in Indigenous Aust...

    Authors: Louise J Maple-Brown, Jaquelyne T Hughes, Zhong X Lu, Kanakamani Jeyaraman, Paul Lawton, Graham RD Jones, Andrew Ellis, Ashim Sinha, Alan Cass, Richard J MacIsaac, George Jerums and Kerin O’Dea
    Citation: Diabetology & Metabolic Syndrome 2014 6:78
    Content type: Research Published on:

  28. This study aimed to evaluate the role of acanthosis nigricans (AN) as a marker of Type 2 Diabetes Mellitus (T2DM) by studying its prevalence and relationship with age, ethnicity, anthropometry and other risk f...

    Authors: Sarasvati Bahadursingh, Catherine Mungalsingh, Terence Seemungal and Surujpal Teelucksingh
    Citation: Diabetology & Metabolic Syndrome 2014 6:77
    Content type: Research Published on:

  29. Glycemic variability (GV) still remains unclear whether acute glycemic excursion has the important prognostic significance in ST-segment elevation myocardial infarction (STEMI) patients undergoing p-PCI. So ou...

    Authors: Jian-wei Zhang, Ling-jie He, Shu-jun Cao, Qing Yang, Shi-wei Yang and Yu-jie Zhou
    Citation: Diabetology & Metabolic Syndrome 2014 6:76
    Content type: Research Published on:

  30. Early identification of high-risk individuals is key for the prevention of cardiovascular disease (CVD). The aim of this study was to assess the potential impact of a family history of metabolic syndrome (fhMe...

    Authors: Anna Lipińska, Magdalena Koczaj-Bremer, Krzysztof Jankowski, Agnieszka Kaźmierczak, Michał Ciurzyński, Aisha Ou-Pokrzewińska, Ewelina Mikocka, Zbigniew Lewandowski, Urszula Demkow and Piotr Pruszczyk
    Citation: Diabetology & Metabolic Syndrome 2014 6:75
    Content type: Research Published on:

  31. To test the effectiveness of a dance program to improve fitness and adherence to physical activity in subjects with type 2 diabetes and obesity.

    Authors: Felice Mangeri, Luca Montesi, Gabriele Forlani, Riccardo Dalle Grave and Giulio Marchesini
    Citation: Diabetology & Metabolic Syndrome 2014 6:74
    Content type: Research Published on:

  32. To compare the first-in-class sodium glucose co-transporter 2 (SGLT2) inhibitor, dapagliflozin, with existing type 2 diabetes mellitus (T2DM) treatment options available within the European Union (EU) for add-...

    Authors: Michelle Orme, Peter Fenici, Isabelle Duprat Lomon, Gail Wygant, Rebecca Townsend and Marina Roudaut
    Citation: Diabetology & Metabolic Syndrome 2014 6:73
    Content type: Review Published on:

  33. Insulin resistance (IR) is closely correlated with cardiovascular disease (CVD). Retinol-binding protein 4 (RBP4) is a novel adipokine that modulates the action of insulin in various diseases. This study addre...

    Authors: Wuquan Deng, Yuping Zhang, Yanling Zheng, Youzhao Jiang, Qinan Wu, Ziwen Liang, Gangyi Yang and Bing Chen
    Citation: Diabetology & Metabolic Syndrome 2014 6:72
    Content type: Research Published on:

  34. The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-...

    Authors: Mei-Fang Li, Ying Ren, Cui-Chun Zhao, Rong Zhang, Lian-Xi Li, Fang Liu, Jun-Xi Lu, Yin-Fang Tu, Wei-Jing Zhao, Yu-Qian Bao and Wei-Ping Jia
    Citation: Diabetology & Metabolic Syndrome 2014 6:71
    Content type: Research Published on:

  35. Elevated serum free fatty acids (FFAs) contribute to the pathogenesis of type-2-diabetes (T2D), and lipotoxicity is observed in many cell types. We recently showed that simulated hyperlipidemia induces lipoapo...

    Authors: Camilla Kappe, Qimin Zhang, Thomas Nyström and Åke Sjöholm
    Citation: Diabetology & Metabolic Syndrome 2014 6:70
    Content type: Research Published on:

  36. The oral DPP-4 inhibitors are new incretin-based therapies for treatment of type 2 diabetes. To assess the efficacy and safety of three DPP-4 inhibitors (Saxagliptin, Sitagliptin and Vildagliptin) as add-on th...

    Authors: Chun-Jun Li, Xiao-Juan Liu, Lian Bai, Qian Yu, Qiu-Mei Zhang, Pei Yu and De-Min Yu
    Citation: Diabetology & Metabolic Syndrome 2014 6:69
    Content type: Research Published on:

  37. This study aimed to explore parameters which will predict good control of HbA1c after adding a second anti-diabetic drug in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin mon...

    Authors: Po-Hsun Chen, Yi-Ting Tsai, Jun-Sing Wang, Shi-Dou Lin, Wen-Jane Lee, Shih-Li Su, I-Te Lee, Shih-Te Tu, Yao-Hsien Tseng, Wayne H-H Sheu and Shih-Yi Lin
    Citation: Diabetology & Metabolic Syndrome 2014 6:68
    Content type: Research Published on:

  38. To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D).

    Authors: Marilia Brito Gomes, Carlos Antonio Negrato, Roberta Cobas, Lucianne Righeti Monteiro Tannus, Paolla Ribeiro Gonçalves, Pedro Carlos Barreto da Silva, João Regis Ivar Carneiro, Alessandra Saldanha Mattos Matheus, Sergio Atala Dib, Mirela Jobim Azevedo, Márcia Nery, Melanie Rodacki, Lenita Zajdenverg, Renan Magalhães Montenegro Junior, Janice Sepulveda, Luis Eduardo Calliari…
    Citation: Diabetology & Metabolic Syndrome 2014 6:67
    Content type: Research Published on:

  39. Higher intake of dietary fiber is associated with lower risk of coronary heart disease, the leading cause of mortality among people with type 1 diabetes. The protective effect includes the anti-inflammatory pr...

    Authors: Fernanda S R Bernaud, Mileni Vanti Beretta, Cigléa do Nascimento, Fabrícia Escobar, Jorge L Gross, Mirela J Azevedo and Ticiana C Rodrigues
    Citation: Diabetology & Metabolic Syndrome 2014 6:66
    Content type: Research Published on:

  41. Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with c...

    Authors: Ken Kishida, Yasuhiko Nakagawa, Hironori Kobayashi, Koji Yanagi, Tohru Funahashi and Iichiro Shimomura
    Citation: Diabetology & Metabolic Syndrome 2014 6:64
    Content type: Research Published on:

  44. Previous gestational diabetes mellitus (pGDM) indicates future risk for type 2 diabetes (T2DM). Insulin resistance (IR) may precede T2DM in many years and is associated with an increased risk for cardiovascula...

    Authors: Lenita Zajdenverg, Melanie Rodacki, Janaina Polo Faria, Maria Lúcia Elias Pires, José Egídio Paulo Oliveira and Vera Lúcia Castro Halfoun
    Citation: Diabetology & Metabolic Syndrome 2014 6:63
    Content type: Research Published on:

  45. Increased epicardial adipose tissue thickness and plasma homocysteine levels are associated with Metabolic Syndrome (MS) and coronary artery disease. The majority of patients with MS have subclinical or manife...

    Authors: Akif Serhat Balcioğlu, Murtaza Emre Durakoğlugil, Davran Çiçek, Uğur Abbas Bal, Bülent Boyaci and Haldun Müderrisoğlu
    Citation: Diabetology & Metabolic Syndrome 2014 6:62
    Content type: Research Published on:

  46. There are a few nutritional approaches to address the increased needs of managing diabetic conditions. Previously it has been reported that UP780, a standardized composition of aloe chromone formulated with an...

    Authors: Mesfin Yimam, Jifu Zhao, Brandon Corneliusen, Mandee Pantier, Lidia Brownell and Qi Jia
    Citation: Diabetology & Metabolic Syndrome 2014 6:61
    Content type: Research Published on:

  47. There is a very well known correlation between diabetes and cardiovascular disease but many health care professionals are just concerned with glycemic control, ignoring the paramount importance of controlling ...

    Authors: Marcello Casaccia Bertoluci, Augusto Pimazoni-Netto, Antonio Carlos Pires, Antonio Eduardo Pesaro, Beatriz D Schaan, Bruno Caramelli, Carisi Anne Polanczyk, Carlos Vicente Serrano Júnior, Danielle M Gualandro, Domingos Augusto Malerbi, Emilio Moriguchi, Flavio Antonio de Oliveira Borelli, João Eduardo Nunes Salles, José Mariani Júnior, Luis Eduardo Rohde, Luis H Canani…
    Citation: Diabetology & Metabolic Syndrome 2014 6:58
    Content type: Review Published on:

  48. Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction...

    Authors: Erik Salum, Mark Butlin, Jaak Kals, Mihkel Zilmer, Jaan Eha, Alberto P Avolio, Andres Arend, Marina Aunapuu and Priit Kampus
    Citation: Diabetology & Metabolic Syndrome 2014 6:57
    Content type: Research Published on:

  49. Oxidized low-density lipoprotein (LDL) plays central roles in the formation and progression of atherosclerotic lesions. Malondialdehyde (MDA)-modified LDL (MDA-LDL) is speculated to be generated as a result of...

    Authors: Masami Tanaka, Risa Nishimura, Takeshi Nishimura, Toshihide Kawai, Shu Meguro, Junichiro Irie, Yoshifumi Saisho and Hiroshi Itoh
    Citation: Diabetology & Metabolic Syndrome 2014 6:56
    Content type: Research Published on:

  50. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Platelet-to-lymphocyte ratio (PLR) and neutrophil-...

    Authors: Emin M Akbas, Hikmet Hamur, Levent Demirtas, Eftal M Bakirci, Adalet Ozcicek, Fatih Ozcicek, Ufuk Kuyrukluyildiz and Kultigin Turkmen
    Citation: Diabetology & Metabolic Syndrome 2014 6:55
    Content type: Research Published on:

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Diabetology & Metabolic Syndrome

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