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  1. Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The unrecognized TD may adversely affect the metabolic control and add more risk to an alre...

    Authors: Cátia Cristina Silva Sousa Vergara Palma, Marco Pavesi, Verônica Guedes Nogueira, Eliete Leão Silva Clemente, Maria de Fátima Bevilacqua Motta Pereira Vasconcellos, Luiz Carlos Pereira Júnior, Fernanda Faissol Pacheco, Tássia Gomide Braga, Ludmila de Faria Bello, Juliana Oliveira Soares, Stefanie Cathren Fenizola dos Santos, Vinícius Paes Leme Cavalcante Campos and Marília Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2013 5:58

    Content type: Research

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  2. Obesity is common in type 2 diabetes (T2DM) and is associated with increased risk of morbidity and all-cause mortality. This analysis describes weight changes associated with insulin detemir initiation in real...

    Authors: Jean-François Yale, Taner Damci, Marcel Kaiser, Eddy Karnieli, Kamlesh Khunti, Andreas Liebl, Florian MM Baeres, Anne Louise Svendsen and Stuart A Ross

    Citation: Diabetology & Metabolic Syndrome 2013 5:56

    Content type: Research

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  3. The purpose of this study is to evaluate the relationship between glycemic control and the factors of knowledge about diabetes, resilience, depression and anxiety among Brazilian adolescents and young adults w...

    Authors: Fabio R Munhoz Santos, Viviane Bernardo, Monica A L Gabbay, Sergio A Dib and Daniel Sigulem

    Citation: Diabetology & Metabolic Syndrome 2013 5:55

    Content type: Research

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  4. To evaluate possible associations between cardiovascular autonomic dysfunction and peripheral artery disease (PAD) in patients with type 2 diabetes mellitus.

    Authors: Luís Henrique Canani, Eduardo Copstein, Miriam Pecis, Rogério Friedman, Cristiane Bauermann Leitão, Mirela Jobim Azevedo, Cristina Triches, Dimitris Rucks Varvaki Rados, Ruy Silveira Moreas and Jorge Luiz Gross

    Citation: Diabetology & Metabolic Syndrome 2013 5:54

    Content type: Research

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  5. It has been hypothesized that fatty acids derived from a diet high in saturated fat may negatively affect endothelial function more significantly than a diet high in unsaturated fat; nevertheless, the effects ...

    Authors: Hady Keita, Eduardo Ramírez-San Juan, Norma Paniagua-Castro, Leticia Garduño-Siciliano and Lucía Quevedo

    Citation: Diabetology & Metabolic Syndrome 2013 5:53

    Content type: Research

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  6. Hypertension frequently coexists with type 2 diabetes (DM), and increases the risk of cardiovascular outcomes. The aim of the study was to obtain/maintain blood pressure (BP) goals (ADA/JNC 7) according to a s...

    Authors: Luciana V Viana, Cristiane B Leitão, Maria F Grillo, Ennio P C C Rocha, Juliana K Brenner, Rogerio Friedman and Jorge L Gross

    Citation: Diabetology & Metabolic Syndrome 2013 5:52

    Content type: Research

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  7. CD36, a class B scavenger receptor, participates in the pathogenesis of metabolic dysregulation such as insulin resistance, hepatic steatosis, and atherosclerosis. Persistent hepatitis C virus (HCV) infection ...

    Authors: Takashi Himoto, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Kazutaka Kurokohchi, Michio Inukai, Hisashi Masugata, Fuminori Goda, Shoichi Senda, Reiji Haba, Masaki Ueno, Genji Yamaoka and Tsutomu Masaki

    Citation: Diabetology & Metabolic Syndrome 2013 5:51

    Content type: Research

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  8. Brazil is expected to have 19.6 million patients with diabetes by the year 2030. A key concept in the treatment of type 2 diabetes mellitus (T2DM) is establishing individualized glycemic goals based on each pa...

    Authors: Marcos Antônio Tambascia, Márcia Nery, Jorge Luiz Gross, Mariana Narbot Ermetice and Carolina Piras de Oliveira

    Citation: Diabetology & Metabolic Syndrome 2013 5:50

    Content type: Review

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  9. During our phylogenetic evolution we have selected genes, the so called thrifty genes, that can help to maximize the amount of energy stored from every consumed calorie. An imbalance in the amount of stored ca...

    Authors: Carlos Antonio Negrato and Marilia Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2013 5:49

    Content type: Review

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    The Retraction Note to this article has been published in Diabetology & Metabolic Syndrome 2014 6:60

  10. The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test ...

    Authors: Stefan Pscherer, Thomas Freude, Thomas Forst, Andreas K Nussler, Karl F Braun and Sabrina Ehnert

    Citation: Diabetology & Metabolic Syndrome 2013 5:48

    Content type: Short report

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  11. Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use of traditional anti-diabetic drugs, in most cases, doe...

    Authors: Asfandyar Sheikh

    Citation: Diabetology & Metabolic Syndrome 2013 5:47

    Content type: Review

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  12. The Brazilian Study on the Practice of Diabetes Care main objective was to provide an epidemiological profile of individuals with type 1 and 2 diabetes mellitus (DM) in Brazil, concerning therapy and adherence...

    Authors: Juarez R Braga, Alvaro Avezum, Sandra RG Ferreira and Adriana Forti

    Citation: Diabetology & Metabolic Syndrome 2013 5:46

    Content type: Research

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  13. Independent of other cardiovascular (CV) risk factors, increased arterial stiffness has been established as a predictor of morbidity and mortality. The main aim of this study was to investigate the impact of d...

    Authors: Rafael de Oliveira Alvim, Paulo Caleb Junior Lima Santos, Mariane Manso Musso, Roberto de Sá Cunha, José Eduardo Krieger, José Geraldo Mill and Alexandre Costa Pereira

    Citation: Diabetology & Metabolic Syndrome 2013 5:45

    Content type: Research

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  14. We aimed to explore the association between presence and number of components of the Metabolic Syndrome (MetS) and subclinical atherosclerosis outcomes (common carotid intima media thickness, plaque presence a...

    Authors: Andrie G Panayiotou, Maura Griffin, Panayiotis Kouis, Theodosis Tyllis, Niki Georgiou, Dawn Bond and Andrew N Nicolaides

    Citation: Diabetology & Metabolic Syndrome 2013 5:44

    Content type: Research

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  15. The aim of this study is to compare the efficacy of intensification of insulin treatment with insulin glargine and biphasic human insulin in patients with type 2 diabetes on concomitant therapy with oral antid...

    Authors: Nicholas Tentolouris, Venetsana Kyriazopoulou, Dimitrios Makrigiannis and Barbara Baroutsou

    Citation: Diabetology & Metabolic Syndrome 2013 5:43

    Content type: Research

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  16. The worldwide epidemic of diabetes and obesity has resulted in a rapid upsurge in the prevalence of metabolic syndrome (MetS). MetS makes the individual liable to endothelial dysfunction which can initiate sex...

    Authors: Nafiu Amidu, William KBA Owiredu, Huseini Alidu, Charity Sarpong, Christian K Gyasi-Sarpong and Lawrence Quaye

    Citation: Diabetology & Metabolic Syndrome 2013 5:42

    Content type: Research

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  17. The phosphodiesterase inhibitor cilostazol has beneficial effects on atherosclerosis by virtue of vasodilatory and antiplatelet effects. However, less is known about the effect of cilostazol on arterial stiffn...

    Authors: Nam Hoon Kim, Hee Young Kim, Hyonggin An, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi and Sin Gon Kim

    Citation: Diabetology & Metabolic Syndrome 2013 5:41

    Content type: Research

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  18. Quantitation of β-cell function is critical in better understanding of the dynamic interactions of insulin secretion, clearance and action at different phases in the progression of diabetes. The present study ...

    Authors: Xiaoli Wang, Barbara C Hansen, Da Shi, Yupeng Fang, Fenglai Du, Bingdi Wang, Yaxiong Michael Chen, Francine M Gregoire and Yi-Xin Jim Wang

    Citation: Diabetology & Metabolic Syndrome 2013 5:40

    Content type: Research

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  19. Diabetes mellitus is a chronic disease that necessitates continuing treatment and patient self-care education. Monitoring of blood glucose to near normal level without hypoglycemia becomes a challenge in the m...

    Authors: Nalinee Poolsup, Naeti Suksomboon and Aye Mon Kyaw

    Citation: Diabetology & Metabolic Syndrome 2013 5:39

    Content type: Research

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  20. Glucose variability could be an independent risk factor for diabetes complications in addition to average glucose. The deficiency in islet β cell secretion and insulin sensitivity, the two important pathophysi...

    Authors: Tong Chen, Feng Xu, Jian-bin Su, Xue-qin Wang, Jin-feng Chen, Gang Wu, Yan Jin and Xiao-hua Wang

    Citation: Diabetology & Metabolic Syndrome 2013 5:38

    Content type: Research

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  21. Hispanics have a high rate of diabetes that exposes them to an increased risk of cardiovascular disease. We hypothesized that many of the pathophysiological mechanisms that cause atherosclerotic disease may be...

    Authors: Carlos O Mendivil, Ludivina Robles-Osorio, Edward S Horton, Osama Hamdy and Augusto Enrique Caballero

    Citation: Diabetology & Metabolic Syndrome 2013 5:37

    Content type: Research

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  22. To investigate the predictive value of different biomarkers for the incidence of type 2 diabetes mellitus (T2DM) in subjects with metabolic syndrome.

    Authors: Michal Ozery-Flato, Naama Parush, Tal El-Hay, Žydrūnė Visockienė, Ligita Ryliškytė, Jolita Badarienė, Svetlana Solovjova, Milda Kovaitė, Rokas Navickas and Aleksandras Laucevičius

    Citation: Diabetology & Metabolic Syndrome 2013 5:36

    Content type: Research

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  23. The landmark Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) placed a new spotlight on thiazide diuretics as the first-line therapy for hypertension. This is concerning as ...

    Authors: Angela L Price, Ildiko Lingvay, Edward W Szczepaniak, Jaime Wiebel, Ronald G Victor and Lidia S Szczepaniak

    Citation: Diabetology & Metabolic Syndrome 2013 5:35

    Content type: Research

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  24. Both acute hyperglycemia as diabetes results in an impaired prognosis in ST-elevation myocardial infarction (STEMI) patients. It is unknown whether there is a different prevalence of diabetes and acute hypergl...

    Authors: Amber M Otten, Jan Paul Ottervanger, Jorik R Timmer, Arnoud WJ van ’t Hof, Jan-Henk E Dambrink, AT Marcel Gosselink, Jan CA Hoorntje, Harry Suryapranata and Angela HEM Maas

    Citation: Diabetology & Metabolic Syndrome 2013 5:34

    Content type: Research

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  26. The aim of this study was to evaluate whether rosuvastatin (HMG-CoA reductase inhibitor) modulates the carbohydrate and lipid metabolism, the development of non-alcoholic fatty liver disease (NAFLD), and the i...

    Authors: Rodrigo Neto-Ferreira, Vinícius Novaes Rocha, Vanessa Souza-Mello, Carlos Alberto Mandarim-de-Lacerda and Jorge José de Carvalho

    Citation: Diabetology & Metabolic Syndrome 2013 5:32

    Content type: Research

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  27. Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes.

    Authors: Vivian C Luft, Maria I Schmidt, James S Pankow, David Couper, Christie M Ballantyne, J Hunter Young and Bruce B Duncan

    Citation: Diabetology & Metabolic Syndrome 2013 5:31

    Content type: Research

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  28. The purpose of the present study was to evaluate the effect and predictive value of metabolic syndrome (MetS) and its components on diastolic heart failure (DHF) in patients at high risk for coronary artery di...

    Authors: Zi-Hui Tang, Fangfang Zeng, Zhongtao Li, Yibing Si and Linuo Zhou

    Citation: Diabetology & Metabolic Syndrome 2013 5:30

    Content type: Research

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  29. High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glyce...

    Authors: Bradley S Henriksen, Mary E Curtis, Natasha Fillmore, Brandon R Cardon, David M Thomson and Chad R Hancock

    Citation: Diabetology & Metabolic Syndrome 2013 5:29

    Content type: Research

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  30. Smoking is an important cause of morbidity and mortality worldwide. It iswidely accepted as a major risk factor for metabolic and cardiovasculardisease. Smoking reduces insulin sensitivity or induces insulin r...

    Authors: Hellas Cena, Antonella Tesone, Rosanna Niniano, Isa Cerveri, Carla Roggi and Giovanna Turconi

    Citation: Diabetology & Metabolic Syndrome 2013 5:28

    Content type: Research

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  31. The purpose of this study was to verify the effects of eight weeks of resistance training (RT) on 24 hour blood pressure (BP) in patients with and without metabolic syndrome (MetS).

    Authors: Ramires Alsamir Tibana, Guilherme Borges Pereira, Jéssica Cardoso de Souza, Vitor Tajra, Denis Cesar Leite Vieira, Carmen Silvia Grubert Campbell, Claudia Regina Cavaglieri and Jonato Prestes

    Citation: Diabetology & Metabolic Syndrome 2013 5:27

    Content type: Research

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  32. Non-exercise activity thermogenesis (NEAT) is the energy expenditure due to physical activities besides active sports-like exercise and resistance training in daily life.

    Authors: Hidetaka Hamasaki, Hidekatsu Yanai, Shuichi Mishima, Tomoka Mineyama, Ritsuko Yamamoto-Honda, Masafumi Kakei, Osamu Ezaki and Mitsuhiko Noda

    Citation: Diabetology & Metabolic Syndrome 2013 5:26

    Content type: Research

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  34. Lipidomic analysis was performed to explore differences in lipid profiles between plasma from lean and obese subjects, followed by in vitro methods to examine a role for the identified lipids in endothelial cell ...

    Authors: Elise L Donovan, Stefan M Pettine, Matthew S Hickey, Karyn L Hamilton and Benjamin F Miller

    Citation: Diabetology & Metabolic Syndrome 2013 5:24

    Content type: Research

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  35. Recent studies revealed that autophagy is up-regulated in obese individuals, as evidenced by increased expression of autophagy related genes. As argued elsewhere, it is possible that initially insulin resistan...

    Authors: Joanna Kosacka, Karoline Koch, Martin Gericke, Marcin Nowicki, John T Heiker, Ingrid Klöting, Michael Stumvoll, Matthias Blüher and Nora Klöting

    Citation: Diabetology & Metabolic Syndrome 2013 5:23

    Content type: Research

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  36. Diabetes is the most common metabolic disorder affecting pregnancy. Its prevalence seems to be growing in parallel with the epidemics of overweight and obesity. Recognizing and treating diabetes or any degree ...

    Authors: Carlos Antonio Negrato and Marilia Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2013 5:22

    Content type: Review

    Published on:

    The Retraction Note to this article has been published in Diabetology & Metabolic Syndrome 2014 6:59

  37. Public health strategies to reduce cardiovascular morbidity and mortality should focus on global cardiometabolic risk reduction. The efficacy of lifestyle changes to prevent type 2 diabetes have been demonstra...

    Authors: Antonela Siqueira-Catania, Adriana Cezaretto, Camila Risso de Barros, Emanuel Péricles Salvador, Tainá Carvalho dos Santos and Sandra RG Ferreira

    Citation: Diabetology & Metabolic Syndrome 2013 5:21

    Content type: Research

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  38. Adiponectin circulates in different multimer complexes comprised of low molecular weight trimeric form (LMW), hexamer of middle molecular weight (MMW) and high molecular weight multimers (HMW). In Japanese-Bra...

    Authors: Felipe Crispim, Marcio F Vendramini and Regina S Moisés

    Citation: Diabetology & Metabolic Syndrome 2013 5:20

    Content type: Research

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  39. Long-acting natriuretic peptide (LANP) is one of the peptide hormones in atrial natriuretic peptide (ANP) pro-hormone. Low levels of natriuretic peptide may lead to reduced lipolysis and excessive weight gain ...

    Authors: Ji-Hung Wang, Chung-Jen Lee, Jen-Che Hsieh, Yu-Chih Chen and Bang-Gee Hsu

    Citation: Diabetology & Metabolic Syndrome 2013 5:19

    Content type: Research

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  40. Glucocorticoids commonly cause drug-induced diabetes. This association is well recognized but available evidence does not answer clinically relevant issues in subjects without diabetes.

    Authors: Jose Gerardo Gonzalez-Gonzalez, Leonor Guadalupe Mireles-Zavala, Rene Rodriguez-Gutierrez, David Gomez-Almaguer, Fernando Javier Lavalle-Gonzalez, Hector Eloy Tamez-Perez, Gerardo Gonzalez-Saldivar and Jesus Zacarias Villarreal-Perez

    Citation: Diabetology & Metabolic Syndrome 2013 5:18

    Content type: Research

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  41. Atherosclerosis is an age-related disease. Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated ci...

    Authors: Hideaki Nakatsuji, Ken Kishida, Hironori Kobayashi, Tohru Nakagawa, Tohru Funahashi and Iichiro Shimomura

    Citation: Diabetology & Metabolic Syndrome 2013 5:17

    Content type: Short report

    Published on:

  42. Impaired mobility and compromised manual dexterity leading to difficulties with the activities of daily living (ADL) are an inherent part of the clinical picture in diabetes. Hand function in diabetes is influ...

    Authors: Jolanta Lewko, Barbara Polityńska, Jan Kochanowicz, Wiesław Zarzycki, Zenon Mariak, Maria Górska and Elżbieta Krajewska-Kułak

    Citation: Diabetology & Metabolic Syndrome 2013 5:16

    Content type: Research

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  43. The Editors of Diabetology and Metabolic Syndrome would like to thank all reviewers, both external and Editorial Board Members, who have contributed to the journal since its inception, and whose valuable suppo...

    Authors: Daniel Giannella-Neto and Marilia de Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2013 5:14

    Content type: Reviewer acknowledgement

    Published on:

  44. Prevalence of Type 2 diabetes mellitus among Sudanese population was found to be 3.4% and associated with high rates of complications and obesity. Different adipocytokines are secreted from adipose tissues, am...

    Authors: Moawia Abdelgadir, Anders F Karlsson, Lars Berglund and Christian Berne

    Citation: Diabetology & Metabolic Syndrome 2013 5:15

    Content type: Research

    Published on:

  45. Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300. A novel water soluble curcumin derivative (NCD) has been developed to overc...

    Authors: Mohamed Talaat Abdel Aziz, Ibrahim Naguib El Ibrashy, Dimitri P Mikhailidis, Ameen Mahmoud Rezq, Mohamed Abdel Aziz Wassef, Hanan Hassan Fouad, Hanan Hosni Ahmed, Dina A Sabry, Heba Mohamed Shawky and Rania Elsayed Hussein

    Citation: Diabetology & Metabolic Syndrome 2013 5:13

    Content type: Research

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  46. Diabetes mellitus is associated with many kinds of complications. Recent studies have shown that oxidative stress and inflammatory reactions have critical roles in the pathogenesis of diabetic gastroparesis. C...

    Authors: Qi-Hui Jin, Hong-Xia Shen, Hui Wang, Qi-Yang Shou and Qiang Liu

    Citation: Diabetology & Metabolic Syndrome 2013 5:12

    Content type: Research

    Published on:

  47. The purpose of the present study was to examine the effects of eight weeks of resistance training (RT) on anthropometric, cardiovascular and biochemical risk factors of metabolic syndrome (MetS), and neuromusc...

    Authors: Ramires Alsamir Tibana, James Navalta, Martim Bottaro, Denis Vieira, Vitor Tajra, Alessandro de Oliveira Silva, Darlan Lopes de Farias, Guilherme Borges Pereira, Jéssica Cardoso de Souza, Sandor Balsamo, Claudia Regina Cavaglieri and Jonato Prestes

    Citation: Diabetology & Metabolic Syndrome 2013 5:11

    Content type: Research

    Published on:

  48. Although incretin therapy is clinically available in patients with type 2 diabetes undergoing hemodialysis, no study has yet examined whether incretin therapy is capable of maintaining glycemic control in this...

    Authors: Yuichi Terawaki, Takashi Nomiyama, Yuko Akehi, Hiromasa Takenoshita, Ryoko Nagaishi, Yoko Tsutsumi, Kunitaka Murase, Hisahiro Nagasako, Nobuya Hamanoue, Kaoru Sugimoto, Ayako Takada, Kenji Ito, Yasuhiro Abe, Yoshie Sasatomi, Satoru Ogahara, Hitoshi Nakashima…

    Citation: Diabetology & Metabolic Syndrome 2013 5:10

    Content type: Research

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  49. The cerebrovasuclar artery disease as a common complication of type-2 diabetes mellitus (T2DM) caused huge economic burden and lives threatening to patients. We evaluated the prevalence and morphology of carot...

    Authors: Ci He, Ming Gu, Rui Jiang and Jian-hao Li

    Citation: Diabetology & Metabolic Syndrome 2013 5:9

    Content type: Research

    Published on:


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