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  1. Insulin resistance (IR) reduces reactivity of the target organ to blood insulin. Researchers have attempted to evaluate IR using various serum lipid concentration ratios. We aimed to determine the most strongl...

    Authors: A Ri Byun, Sang Wha Lee, Hong Soo Lee and Kyung Won Shim
    Citation: Diabetology & Metabolic Syndrome 2015 7:59
  2. Many studies evaluated the best predictors for cardiovascular disease (CVD) events in individuals with type 2 diabetes (T2D), but few studies examined the factors most strongly associated with mortality in T2D...

    Authors: Laura M. Raffield, Fang-Chi Hsu, Amanda J. Cox, J. Jeffrey Carr, Barry I. Freedman and Donald W. Bowden
    Citation: Diabetology & Metabolic Syndrome 2015 7:58
  3. The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter a...

    Authors: Marcos Antonio Tambascia and Freddy Goldberg Eliaschewitz
    Citation: Diabetology & Metabolic Syndrome 2015 7:57
  4. We examined the feasibility and efficacy of using a non-mydriatic camera to screen for diabetic retinopathy (DR) among youth with type 1 or type 2 diabetes seen in a pediatric endocrinology clinic serving Alab...

    Authors: Jeffrey L. Tapley, Gerald McGwin Jr., Ambika P. Ashraf, Paul A. MacLennan, Koula Callahan, Karen Searcey, C. Douglas Witherspoon, Jinan Saaddine and Cynthia Owsley
    Citation: Diabetology & Metabolic Syndrome 2015 7:56
  5. Type 2 diabetes (T2D) is very prevalent among the elderly. Insulin therapy is often required for glycemic control. The association of starting this therapy with depressive symptoms as well the health-related q...

    Authors: R. A. Oliveira, M. Tostes, V. A. Queiroz, M. Rodacki and L. Zajdenverg
    Citation: Diabetology & Metabolic Syndrome 2015 7:55
  6. The initial discovery of resistin and resistin-like molecules (RELMs) in rodents suggested a role for these adipocytokines in molecular linkage of obesity, Type 2 Diabetes mellitus and metabolic syndrome. Sinc...

    Authors: Fatima Al Hannan and Kevin Gerard Culligan
    Citation: Diabetology & Metabolic Syndrome 2015 7:54
  7. Low levels of vitamin D have been related to increased mortality and morbidity in several non-diabetic studies. We aimed to prospectively study relationships between serum 25-OH vitamin D3 (vitamin D) and of seru...

    Authors: Pär Jennersjö, Hans Guldbrand, Stefan Björne, Toste Länne, Mats Fredrikson, Torbjörn Lindström, Magnus Wijkman, Carl Johan Östgren and Fredrik H. Nystrom
    Citation: Diabetology & Metabolic Syndrome 2015 7:53
  8. A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D...

    Authors: D.B. Araujo de Pina Cabral, J.R. Dantas, H. Skärstrand, B. Barone, F. Carvalho, R. Tortora, A. Milech, F. Vaziri-Sani, J.E. P. Oliveira, L. Zajdenverg and M. Rodacki
    Citation: Diabetology & Metabolic Syndrome 2015 7:52
  9. Peripheral Diabetic Neuropathy (PDN) and cognitive impairment are complications of Diabetes Mellitus (DM) that seem to share several underlying mechanisms. The aim of this study was to investigate whether diab...

    Authors: Rodrigo O. Moreira, Ana Luiza Soldera, Bruno Cury, Carolina Meireles and Rosane Kupfer
    Citation: Diabetology & Metabolic Syndrome 2015 7:51
  10. DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of La...

    Authors: Takanori Shinjo, Yusuke Nakatsu, Misaki Iwashita, Tomomi Sano, Hideyuki Sakoda, Hisamitsu Ishihara, Akifumi Kushiyama, Midori Fujishiro, Fusanori Nishimura and Tomoichiro Asano
    Citation: Diabetology & Metabolic Syndrome 2015 7:50
  11. The highly active antiretroviral therapy (HAART) has altered the course of HIV infection, transforming it from a fatal illness to a chronic condition, reducing morbidity and mortality. However, this therapy ha...

    Authors: Miguel A. Guillen, Fernando A. Mejia, Jaime Villena, Christie G. Turin, Cesar P. Carcamo and Ray Ticse
    Citation: Diabetology & Metabolic Syndrome 2015 7:49
  12. Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Since SGLT-2-mediated...

    Authors: Nobutaka Nakamura, Takanori Matsui, Yuji Ishibashi and Sho-ichi Yamagishi
    Citation: Diabetology & Metabolic Syndrome 2015 7:48
  13. Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to ass...

    Authors: Clarisse Noël Ayina Ayina, Eugene Sobngwi, Mickael Essouma, Jean Jacques N. Noubiap, Philippe Boudou, Laurent Serge Etoundi Ngoa and Jean François Gautier
    Citation: Diabetology & Metabolic Syndrome 2015 7:47
  14. Female abdominal obesity is associated with hyperandrogenemia (HA), but few studies have addressed the possible association between HA and metabolic syndrome (MetS) among obese women. Some studies indicate tha...

    Authors: T.G. Valderhaug, J.K. Hertel, N. Nordstrand, P.O. Dale, D. Hofsø and J. Hjelmesæth
    Citation: Diabetology & Metabolic Syndrome 2015 7:46
  15. Although the health burden of shift work has not been extensively studied, evidence suggests that it may affect the metabolic balance and cause obesity and other metabolic disorders. Sleep deprivation, circadi...

    Authors: Maria Carlota Borba Brum, Fábio Fernandes Dantas Filho, Claudia Carolina Schnorr, Gustavo Borchardt Bottega and Ticiana C. Rodrigues
    Citation: Diabetology & Metabolic Syndrome 2015 7:45
  16. Incretin therapy is feasible in patients with type 2 diabetes mellitus undergoing hemodialysis (HD). However, few studies have examined the safety and efficacy of this therapeutic approach in patients with dia...

    Authors: Yuichi Terawaki, Takashi Nomiyama, Hiroyuki Takahashi, Yoko Tsutsumi, Kunitaka Murase, Ryoko Nagaishi, Makito Tanabe, Tadachika Kudo, Kunihisa Kobayashi, Tetsuhiko Yasuno, Hitoshi Nakashima and Toshihiko Yanase
    Citation: Diabetology & Metabolic Syndrome 2015 7:44
  17. Women with gestational diabetes mellitus (GDM) are at an increased risk of developing metabolic syndrome (MetS) after delivery. Recently, the prevalence of both GDM and MetS has increased worldwide, in paralle...

    Authors: Tiina Vilmi-Kerälä, Outi Palomäki, Merja Vainio, Jukka Uotila and Ari Palomäki
    Citation: Diabetology & Metabolic Syndrome 2015 7:43
  18. Guidelines increasingly encourage the use of multivariable risk models to predict the presence of prevalent undiagnosed type 2 diabetes mellitus worldwide. However, no single model can perform well in all sett...

    Authors: Katya Masconi, Tandi E. Matsha, Rajiv T. Erasmus and Andre P. Kengne
    Citation: Diabetology & Metabolic Syndrome 2015 7:42
  19. Type 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental co...

    Authors: Elvis Ndonwi Ngwa, Andre-Pascal Kengne, Barbara Tiedeu-Atogho, Edith-Pascale Mofo-Mato and Eugene Sobngwi
    Citation: Diabetology & Metabolic Syndrome 2015 7:41
  20. Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is associated with diabetes mellitus and cardiovascular disease. Lifestyle interventions applied to people with MetS has consider...

    Authors: Parco M Siu, Angus P Yu, Iris F Benzie and Jean Woo
    Citation: Diabetology & Metabolic Syndrome 2015 7:40
  21. In mammals, the temperature rhythm is regulated by the circadian pacemaker located in the suprachiasmatic nuclei, and is considered a “marker rhythm”. Melatonin, the pineal gland hormone, is a major regulator ...

    Authors: Angela M Ramos-Lobo, Daniella C Buonfiglio and José Cipolla-Neto
    Citation: Diabetology & Metabolic Syndrome 2015 7:39
  22. The HSD11B1 gene is highly expressed in abdominal adipose tissue, and the enzyme it encodes catalyzes the interconversion of inactive cortisone to hormonally active cortisol. Genetic abnormalities of HSD11B1 have...

    Authors: Filipe Valvassori do Nascimento, Vanessa Piccoli, Mayara Abichequer Beer, Anize Delfino von Frankenberg, Daisy Crispim and Fernando Gerchman
    Citation: Diabetology & Metabolic Syndrome 2015 7:38
  23. There remains controversy regarding which of the anthropometric indicators best defines obesity. In this study, we compared the efficacy of using body mass index (BMI), waist circumference (WC) and waist-to-hi...

    Authors: Xiaojun Ouyang, Qinlin Lou, Liubao Gu, Gary T Ko, Yongzhen Mo, Haidi Wu and Rongwen Bian
    Citation: Diabetology & Metabolic Syndrome 2015 7:37
  24. There is a clinical imperative to improve metabolic control in the treatment of patients with type 1 diabetes, but in doing so, hypoglycemia should be avoided at all costs. Insulin analogues and the assumption...

    Authors: Beatriz D Schaan and Rafael Selbach Scheffel
    Citation: Diabetology & Metabolic Syndrome 2015 7:35
  25. Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polym...

    Authors: Raquel de Oliveira, Tamiris Invencioni Moraes, Alvaro Cerda, Mario Hiroyuki Hirata, Cristina Moreno Fajardo, Marcela Correia Sousa, Egidio Lima Dorea, Márcia Martins Silveira Bernik and Rosario Dominguez Crespo Hirata
    Citation: Diabetology & Metabolic Syndrome 2015 7:34
  26. Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the r...

    Authors: Wuquan Deng, Changyan Li, Yuping Zhang, Jie Zhao, Mengliu Yang, Mingyuan Tian, Ling Li, Yanling Zheng, Bing Chen and Gangyi Yang
    Citation: Diabetology & Metabolic Syndrome 2015 7:33
  27. Growth-curves are an important tool for evaluating the anthropometric development in pediatrics. The different growth-curves available are based in different populations, what leads to different cut-offs.

    Authors: Henrique Nascimento, Cristina Catarino, Denisa Mendonça, Pedro Oliveira, Ana Inês Alves, Ana Filipa Medeiros, Petronila Rocha Pereira, Carla Rêgo, Helena Ferreira Mansilha, Luísa Aires, Jorge Mota, Alexandre Quintanilha, Alice Santos-Silva and Luís Belo
    Citation: Diabetology & Metabolic Syndrome 2015 7:32
  28. Low health literacy is associated with worse glycemic control among patients with diabetes; the relationship between health literacy and blood glucose among patients without diagnosed diabetes, particularly in...

    Authors: Candace D McNaughton, Rosalynne R Korman, Edmond K Kabagambe and Seth W Wright
    Citation: Diabetology & Metabolic Syndrome 2015 7:31
  29. Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin...

    Authors: Rafael B Gelaleti, Débora C Damasceno, Daisy M F Salvadori, João Paulo C Marcondes, Paula H O Lima, Glilciane Morceli, Iracema M P Calderon and Marilza V C Rudge
    Citation: Diabetology & Metabolic Syndrome 2015 7:30
  30. Dunnigan type Familial Partial Lipodystrophy (FPLD) is characterized by loss of subcutaneous fat from the limbs and excessive accumulation on the visceral adipose tissue (VAT). Affected individuals have insuli...

    Authors: Amélio Fernando Godoy-Matos, Cynthia M Valério, Juliana Bonadiman e Bragança, Ricardo de Andrade Oliveira, Roberto Luis Zagury, Rodolfo de Paula Lustosa, Gabriel Cordeiro Camargo, César Augusto da Silva Nascimento and Rodrigo O Moreira
    Citation: Diabetology & Metabolic Syndrome 2015 7:29
  31. In patients with diabetes, studies investigating the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcium score (CACS) have shown conflicting results. The aim of this study ...

    Authors: Min-Sun Kwak, Jeong Yoon Yim, Donghee Kim, Min Jung Park, Seon Hee Lim, Jong In Yang, Goh Eun Chung, Young Sun Kim, Sun Young Yang, Mi Na Kim, Chang-Hoon Lee, Jung-Hwan Yoon and Hyo-Suk Lee
    Citation: Diabetology & Metabolic Syndrome 2015 7:28
  32. To compare microvascular reactivity assessed in the skin using laser Doppler fluximetry (LDF) in women with gestational diabetes mellitus (GDM) and gestational age-matched control during pregnancy.

    Authors: Isabelle EA Pontes, Karine F Afra, José R Silva Jr, Paulo SN Borges, Geraldine F Clough and João GB Alves
    Citation: Diabetology & Metabolic Syndrome 2015 7:27
  33. Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in mid...

    Authors: Xinmiao Xie, Ting Gao, Meili Yang, Peihong Chen, Hua Jin, Lili Yang and Xuemei Yu
    Citation: Diabetology & Metabolic Syndrome 2015 7:26
  34. Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally, irregular sleep, shift wo...

    Authors: Anne Briançon-Marjollet, Martin Weiszenstein, Marion Henri, Amandine Thomas, Diane Godin-Ribuot and Jan Polak
    Citation: Diabetology & Metabolic Syndrome 2015 7:25
  35. The medical literature shows that alcohol consumption is common among diabetic individuals and is associated with poor adherence to treatment, resulting in increased morbidity and mortality. However, no study ...

    Authors: Maria Aparecida Knychala, Maria Luiza Mendonça Pereira Jorge, Cinara Knychala Muniz, Priscila Neves Faria and Paulo Tannús Jorge
    Citation: Diabetology & Metabolic Syndrome 2015 7:24
  36. Endothelial dysfunction which is induced by serum saturated fatty acids increasing is one of pathogenesis of diabetic retinopathy (DR). The intestinal fatty acid binding protein-2 (FABP2) Ala54Thr polymorphism...

    Authors: Zhu Li, Chang-Lin Ni, Wen-yan Niu, Bao-cheng Chang and Li-Ming Chen
    Citation: Diabetology & Metabolic Syndrome 2015 7:23
  37. Women diagnosed with gestational diabetes mellitus have an increased risk of developing diabetes mellitus, which is a known risk factor for cardiovascular disease and insulin resistance. In the recently publis...

    Authors: Huseyin Kayadibi, Erdim Sertoglu and Metin Uyanik
    Citation: Diabetology & Metabolic Syndrome 2015 7:22
  38. Despite the increasing prevalence of diabetes and other health consequences of obesity, little is known on the metabolic profile across categories of body mass index (BMI) among African populations. We therefo...

    Authors: Vivian N Mbanya, Justin B Echouffo-Tcheugui, Hussain Akhtar, Jean-Claude Mbanya and Andre P Kengne
    Citation: Diabetology & Metabolic Syndrome 2015 7:21
  39. Elevated concentrations of plasma glucose appear to play a role in memory impairment, and it has been suggested that insulin might also have a negative effect on cognitive function. Our aim was to study whethe...

    Authors: Anna Backeström, Sture Eriksson, Lars-Göran Nilsson, Tommy Olsson and Olov Rolandsson
    Citation: Diabetology & Metabolic Syndrome 2015 7:20
  40. Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-κB (NFκB...

    Authors: Ana Cláudia Poletto, Aline David-Silva, Aline Pedro de Melo Yamamoto, Ubiratan Fabres Machado and Daniela Tomie Furuya
    Citation: Diabetology & Metabolic Syndrome 2015 7:18
  41. To evaluate the association between fasting glucose levels in women throughout pregnancy and the occurrence of gestational diabetes mellitus (GDM) and other pregnancy complications, macrosomia, and cesarean de...

    Authors: Gisele Seabra, Cláudia Saunders, Patrícia de Carvalho Padilha, Lenita Zajdenverg, Letícia Barbosa Gabriel da Silva and Marta Maria Antonieta de Souza Santos
    Citation: Diabetology & Metabolic Syndrome 2015 7:17
  42. The prevalence of obesity and Type 2 diabetes mellitus (T2DM) among children and adolescents is rising. Thyroid function has been associated with insulin resistance. There is scarce information about how thyro...

    Authors: José de Jesús Garduño-Garcia, Eneida Camarillo Romero, Ana Loe Ochoa, Socorro Romero-Figueroa, Gerardo Huitron Bravo, Roció Torres García, Patricia Montenegro-Morales and Hugo Mendieta-Zerón
    Citation: Diabetology & Metabolic Syndrome 2015 7:16
  43. Metabolic syndrome (MetS) is a constellation of symptoms used as a measure to identify patients at increased risk for cardiovascular disease, type 2 diabetes, and all-cause mortality. The results of prolonged ...

    Authors: Eduard Tiozzo, Janet Konefal, Sarah Adwan, Lynell A Martinez, Juan Villabona, Johanna Lopez, Stacy Cutrono, Syed Muhammad Ahsan Mehdi, Allan Rodriguez, Judi M Woolger and John E Lewis
    Citation: Diabetology & Metabolic Syndrome 2015 7:15
  44. Type 2 diabetes mellitus (T2D) is a complex disease associated with several chronic complications, including bone fragility and high fracture risk due to mechanisms not yet fully understood. The influence of t...

    Authors: Laura S Girão Lopes, Rubens Prado Schwartz, Bruno Ferraz-de-Souza, Maria Elizabeth Rossi da Silva, Pedro Henrique Silveira Corrêa and Márcia Nery
    Citation: Diabetology & Metabolic Syndrome 2015 7:13
  45. Obesity is characterized by low grade inflammation and an altered secretion of inflammatory cytokines from the adipose tissue. Weight loss has shown to reduce inflammation; however, changes in cytokine profile...

    Authors: Kirsten Katrine Lindegaard, Nils Bruun Jorgensen, Rasmus Just, Peter MH Heegaard and Sten Madsbad
    Citation: Diabetology & Metabolic Syndrome 2015 7:12
  46. Elevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chi...

    Authors: Qin Tang, Zhenfang Liu, Yan Tang, Aihua Tan, Yong Gao, Zheng Lu, Qiuyan Wang, Yingchun Chen, Chunlei Wu, Haiying Zhang, Xiaobo Yang and Zengnan Mo
    Citation: Diabetology & Metabolic Syndrome 2015 7:11
  47. The Editors of Diabetology & Metabolic Syndrome would like to thank all of our reviewers, both external and Editorial Board Members, who have contributed to the journal in Volume 6 (2014) and whose valuable suppo...

    Authors: Daniel Giannella-Neto
    Citation: Diabetology & Metabolic Syndrome 2015 7:10

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