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  1. Although several studies showed that decreased soluble receptor for advanced glycation end products (sRAGE) is associated with metabolic syndrome (MetS), inflammation level has not been considered, even though...

    Authors: Haruki Momma, Kaijun Niu, Yoritoshi Kobayashi, Cong Huang, Masahiko Chujo, Atsushi Otomo, Hiroko Tadaura, Toshio Miyata and Ryoichi Nagatomi

    Citation: Diabetology & Metabolic Syndrome 2014 6:33

    Content type: Research

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  2. The incidence of macrovascular complications and morbidities associated to metabolic syndrome are increasing in patients with type 1 diabetes mellitus (T1DM). The combination of T1DM with features of insulin r...

    Authors: Aldo Ferreira-Hermosillo, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta and Mario A Molina-Ayala

    Citation: Diabetology & Metabolic Syndrome 2014 6:32

    Content type: Research

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  3. The recent Latin American and European guidelines published this year has proposed as a goal for blood pressure control in patients with diabetes type 2 a value similar or inferior to 140/90 mmHg. High blood p...

    Authors: Patricio Lopez-Jaramillo, Jose Lopez-Lopez, Cristina Lopez-Lopez and Miguel I Rodriguez-Alvarez

    Citation: Diabetology & Metabolic Syndrome 2014 6:31

    Content type: Review

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  4. Fenofibrate offers a number of benefits on the cardiovascular system and it is plausible that its anti-inflammatory, anti-oxidant and anti-fibrotic effects and enhancement of cardiac metabolic performances may...

    Authors: Cristina Nita, Cornelia Bala, Mihai Porojan and Nicolae Hancu

    Citation: Diabetology & Metabolic Syndrome 2014 6:30

    Content type: Research

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  5. This study investigated the effect of exenatide on the cardiac expression of adiponectin receptor 1 and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits and heart function in streptozotocin...

    Authors: Zhixin Guo, Wei Qi, Yuanxian Yu, Shijing Du, Jieping Wu and Jinjin Liu

    Citation: Diabetology & Metabolic Syndrome 2014 6:29

    Content type: Research

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  6. The aim of our study was to evaluate the associations between arterial stiffness indexes and immune-inflammatory markers in subjects with acute ischemic stroke with and without metabolic syndrome.

    Authors: Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Riccardo Di Sciacca, Baldassare Canino, Valentina Arnao, Carmelo Buttà, Vittoriano Della Corte, Carlo Maida, Giuseppe Licata and Antonio Pinto

    Citation: Diabetology & Metabolic Syndrome 2014 6:28

    Content type: Research

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  7. A high-calorie diet and physical inactivity, an imbalance between caloric intake and energy consumption, are major causes of metabolic syndrome (MetS), which manifests as accumulation of visceral fat and insul...

    Authors: Shusuke Yagi, Muneyuki Kadota, Ken-ichi Aihara, Koji Nishikawa, Tomoya Hara, Takayuki Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Michio Shimabukuro, Shinsuke Katoh and Masataka Sata

    Citation: Diabetology & Metabolic Syndrome 2014 6:27

    Content type: Research

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  8. Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels ma...

    Authors: Anize D von Frankenberg, Filipe V do Nascimento, Lucas Eduardo Gatelli, Bárbara L Nedel, Sheila P Garcia, Carolina SV de Oliveira, Pedro Saddi-Rosa, André F Reis, Luis H Canani and Fernando Gerchman

    Citation: Diabetology & Metabolic Syndrome 2014 6:26

    Content type: Research

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  9. Retinol-binding protein 4 (RBP4), a novel adipokine secreted by adipocytes and the liver, has elevated levels in type 2 diabetes mellitus (T2DM). However, its association with human metabolic diseases remains ...

    Authors: Yan Liu, Duan Wang, Di Li, Ruifang Sun and Min Xia

    Citation: Diabetology & Metabolic Syndrome 2014 6:25

    Content type: Research

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  10. Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data fro...

    Authors: Michel M Joosten, Ilse C Schrieks and Henk FJ Hendriks

    Citation: Diabetology & Metabolic Syndrome 2014 6:24

    Content type: Research

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  11. Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk of heart disease, stroke and diabetes. Since pathways implicated in different diseases reveal surprising insights i...

    Authors: Vânia Gaio, Baltazar Nunes, Aida Fernandes, Francisco Mendonça, Filomena Horta Correia, Álvaro Beleza, Ana Paula Gil, Mafalda Bourbon, Astrid Vicente, Carlos Matias Dias and Marta Barreto da Silva

    Citation: Diabetology & Metabolic Syndrome 2014 6:23

    Content type: Research

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  12. Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This stud...

    Authors: Luciana Dias Folchetti, Milena Monfort-Pires, Camila R de Barros, Lígia Araújo Martini and Sandra Roberta Gouvea Ferreira

    Citation: Diabetology & Metabolic Syndrome 2014 6:22

    Content type: Research

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  13. Diabetes mellitus (DM) and intermittent claudication (IC) are frequently associated health conditions. Our hypothesis is that the nature, severity and quality of life (QoL) of patients with IC and DM are worse...

    Authors: Francisco S Lozano, José R González-Porras, José R March, José M Lobos, Eduardo Carrasco and Eduardo Ros

    Citation: Diabetology & Metabolic Syndrome 2014 6:21

    Content type: Research

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  14. A dd-on L antus® to O ral H ypoglycemic A gents (ALOHA), an observational, non-interventional, 24-week post-marketing surveillance study in Japanese patients with type 2 diabetes (T2DM) having uncontrolled glycem...

    Authors: Masato Odawara, Takashi Kadowaki and Yusuke Naito

    Citation: Diabetology & Metabolic Syndrome 2014 6:20

    Content type: Research

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  15. The relationship of saliva with plasma protein levels makes saliva an attractive diagnostic tool. Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previous...

    Authors: Supanee Thanakun, Hisashi Watanabe, Sroisiri Thaweboon and Yuichi Izumi

    Citation: Diabetology & Metabolic Syndrome 2014 6:19

    Content type: Research

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  16. Obesity, a critical component of metabolic syndrome (MetS), is associated with depression. Deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. We hypothesized tha...

    Authors: I-Te Lee, Chia-Po Fu, Wen-Jane Lee, Kae-Woei Liang, Shih-Yi Lin, Chu-Jen Wan and Wayne Huey-Herng Sheu

    Citation: Diabetology & Metabolic Syndrome 2014 6:18

    Content type: Research

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  17. About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephro...

    Authors: Bruno Schmidt Dellamea, Cristiane Bauermann Leitão, Rogério Friedman and Luis Henrique Canani

    Citation: Diabetology & Metabolic Syndrome 2014 6:17

    Content type: Review

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  18. Glycated hemoglobin (A1C) and Fasting Plasma Glucose (FPG) are the two monitoring blood glucose tests most frequently used. However, both methods are shown to be insensitive to detect glycemic variations in sh...

    Authors: Bruno P Moura, Paulo RS Amorim, Bruno PP Silva, Sylvia CC Franceschini, Janice S Reis and João CB Marins

    Citation: Diabetology & Metabolic Syndrome 2014 6:16

    Content type: Research

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  19. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) was lower in the general population with metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between MetS and fasting s...

    Authors: Ji-Hung Wang, Chung-Jen Lee, Jen-Che Hsieh, Yu-Chih Chen and Bang-Gee Hsu

    Citation: Diabetology & Metabolic Syndrome 2014 6:15

    Content type: Research

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  20. Individuals with diabetes may develop cardiac autonomic dysfunction that may be evaluated by heart rate variability (HRV). The aim was evaluated heart rate variability (HRV) of individuals with type 2 diabetes...

    Authors: Sílvia CG Moura-Tonello, Anielle CM Takahashi, Cristina O Francisco, Sérgio LB Lopes, Adriano M Del Vale, Audrey Borghi-Silva, Angela MO Leal, Nicola Montano, Alberto Porta and Aparecida M Catai

    Citation: Diabetology & Metabolic Syndrome 2014 6:13

    Content type: Research

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  21. Waist circumference (WC) is used as a risk assessment for metabolic syndrome, diabetes, and cardiovascular disease (CVD). WC consists of visceral fat area (VFA), subcutaneous fat area (SFA), muscle, intramuscu...

    Authors: Yumi Matsushita, Toru Nakagawa, Michihiro Shinohara, Shuichiro Yamamoto, Yoshihiko Takahashi, Tetsuya Mizoue, Tetsuji Yokoyama and Mitsuhiko Noda

    Citation: Diabetology & Metabolic Syndrome 2014 6:11

    Content type: Research

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  22. The Editors of Diabetology and Metabolic Syndrome would like to thank all our reviewers who have contributed to the journal in Volume 5 (2013).

    Authors: Daniel Giannella-Neto and Marilia de Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2014 6:9

    Content type: Reviewer acknowledgement

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  23. The obese Zücker diabetic fatty male rat (ZDF:Gmi™-fa) is an animal model of type II diabetes associated with obesity and related metabolic disturbances like dyslipidaemia and diabetic nephropathy. In addition...

    Authors: Eduardo J Lezcano, Pablo Iñigo, Ana M Larraga, Cristina Barranquero, Ignacio Gimenez and Jesús Osada

    Citation: Diabetology & Metabolic Syndrome 2014 6:10

    Content type: Research

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  24. The etiology of the metabolic syndrome is complex, and is determined by the interplay of both genetic and environmental factors. The present study was designed to identify genes and proteins in the adipose tis...

    Authors: Jie Chang, Shinji Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda, Chieko Aoki, Yoshiji Yamada, Gaku Ichihara, Masashi Kato and Sahoko Ichihara

    Citation: Diabetology & Metabolic Syndrome 2014 6:8

    Content type: Research

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  25. Vitamin D deficiency has been linked to several cardiovascular risk factors but information regarding vitamin D concentrations in familial combined hyperlipidemia (FCHL) is lacking. Our objective was to examin...

    Authors: Inka Miñambres, Jose Luis Sánchez-Quesada, Joan Sánchez-Hernández, Jose Rodríguez, Alberto de Leiva and Antonio Pérez

    Citation: Diabetology & Metabolic Syndrome 2014 6:7

    Content type: Research

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  26. Metabolic syndrome is a cluster of metabolic risk factors including dyslipidemia, impaired glucose tolerance, hypertension and central obesity. BDNF (Brain-derived neurotrophic factor) and leptin have been imp...

    Authors: Kanjana Suriyaprom, Rungsunn Tungtrongchitr and Kittisak Thawnasom

    Citation: Diabetology & Metabolic Syndrome 2014 6:6

    Content type: Research

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  27. Type 2 diabetes mellitus patients with an acute coronary event (ACE) experience decreased quality of life and increased distress. According to the American Diabetes Association, discharge from the hospital is ...

    Authors: Marise J Kasteleyn, Kees J Gorter, Rebecca K Stellato, Mieke Rijken, Giel Nijpels and Guy EHM Rutten

    Citation: Diabetology & Metabolic Syndrome 2014 6:5

    Content type: Research

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  28. Dysregulation of omentin-1, a beneficial adipokine, is thought to play a role in the development of type 2 diabetes and cardiovascular disease. The objective of this study was to evaluate the relationship betw...

    Authors: Anh Vu, Maha S Sidhom, Brooke C Bredbeck, Lisa A Kosmiski and Christina L Aquilante

    Citation: Diabetology & Metabolic Syndrome 2014 6:4

    Content type: Research

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  29. Glucocorticoid excess is commonly associated with diabetogenic effects, including insulin resistance and glucose intolerance. The effects of the long-term glucagon-like peptide 1 receptor agonist treatment on ...

    Authors: Liselotte Fransson, Cristiane dos Santos, Petra Wolbert, Åke Sjöholm, Alex Rafacho and Henrik Ortsäter

    Citation: Diabetology & Metabolic Syndrome 2014 6:3

    Content type: Research

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  30. To study mortality rates among patients with diabetes and concomitant atrial fibrillation (AF), prescribed different cardiovascular drugs in primary health care.

    Authors: Per Wändell, Axel C Carlsson, Jan Sundquist, Sven-Erik Johansson, Matteo Bottai and Kristina Sundquist

    Citation: Diabetology & Metabolic Syndrome 2014 6:2

    Content type: Research

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  31. Metabolic syndrome (MS) is a condition associated with obesity that identifies individuals with increased cardiovascular risk. Gastric bypass improves several MS components, such as glucose, lipid metabolism a...

    Authors: Mário Nora, Marta Guimarães, Rui Almeida, Paulo Martins, Gil Gonçalves, Mariana Santos, Tiago Morais, Cláudia Freitas and Mariana P Monteiro

    Citation: Diabetology & Metabolic Syndrome 2014 6:1

    Content type: Research

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  32. Regional differences in the clinical care of Type 1 diabetes (T1D) in Brazil have been recently described. This study aimed to estimate the costs of T1D from the public health care system’s perspective across ...

    Authors: Roberta Arnoldi Cobas, Marcos Bosi Ferraz, Alessandra Saldanha de Mattos Matheus, Lucianne Righeti Monteiro Tannus, Aline Tiemi Kano Silva, Luiz Antonio de Araujo, Carlos Antonio Negrato, Sérgio Atala Dib and Marilia Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2013 5:83

    Content type: Research

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  33. Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim ...

    Authors: Erika P Guedes, Eduardo Madeira, Thiago T Mafort, Miguel Madeira, Rodrigo O Moreira, Laura MC Mendonça, Amélio F Godoy-Matos, Agnaldo J Lopes and Maria Lucia F Farias

    Citation: Diabetology & Metabolic Syndrome 2013 5:82

    Content type: Research

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  34. This study aimed at investigating whether impaired fasting glucose (IFG) is an independent risk factor for incident hypertension among middle-aged Japanese subjects with optimal blood pressure (OBP).

    Authors: Masaaki Morio, Machiko Inoue, Kazuo Inoue and Kimihiko Akimoto

    Citation: Diabetology & Metabolic Syndrome 2013 5:81

    Content type: Short report

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  35. The use of diuretics for hypertension has been associated with unfavorable changes in cardiovascular risk factors, such as uric acid and glucose tolerance, though the findings in the literature are contradictory.

    Authors: Silvio Buscemi, Antonio Nicolucci, Giuseppe Lucisano, Fabio Galvano, Giuseppe Grosso, Fatima M Massenti, Emanuele Amodio, Alice Bonura, Delia Sprini and Giovam B Rini

    Citation: Diabetology & Metabolic Syndrome 2013 5:80

    Content type: Research

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  36. Peroxisome proliferator-activated receptor gamma (PPARγ) has direct and indirect function in adipokines production process. We aimed to assess the possible influence of circulating PPARγ on relative risk of me...

    Authors: Khadijeh Mirzaei, Arash Hossein-nezhad, Seyed Ali Keshavarz, Fariba Koohdani, Ali Akbar Saboor-Yaraghi, Saeed Hosseini, Mohammad Reza Eshraghian and Mahmoud Djalali

    Citation: Diabetology & Metabolic Syndrome 2013 5:79

    Content type: Research

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  37. A residual risk of cardiovascular disease tends to persist despite standard prevention therapy with statins. This may stem partly from increased oxidized low-density lipoprotein (LDL) levels. However, how oxid...

    Authors: Morihiro Matsuda, Ritsu Tamura, Kotaro Kanno, Takatsugu Segawa, Haruyuki Kinoshita, Orie Nishimoto, Hirohiko Nishiyama and Toshiharu Kawamoto

    Citation: Diabetology & Metabolic Syndrome 2013 5:77

    Content type: Research

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  38. Diabetes mellitus, as a risk factor for endometrial cancer (EC), causes an increase in insulin and IGF-1 concentrations in the blood serum. The increase in insulin and IGF-1 are considered mitogenic factors co...

    Authors: Anna Markowska, Monika Pawałowska, Violetta Filas, Konstanty Korski, Marian Gryboś, Stefan Sajdak, Anita Olejek, Wiesława Bednarek, Beata Śpiewankiewicz, Jolanta Lubin and Janina Markowska

    Citation: Diabetology & Metabolic Syndrome 2013 5:76

    Content type: Research

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  39. Several studies highlight curcumin’s benefit as a hypoglycemic agent, however; a limited number of reports present the importance of curcumin in improvement of pancreatic islets in diabetes. The aim of the pre...

    Authors: Mohamed T Abdel Aziz, Mohamed F El-Asmar, Ameen M Rezq, Soheir M Mahfouz, Mohamed A Wassef, Hanan H Fouad, Hanan H Ahmed and Fatma M Taha

    Citation: Diabetology & Metabolic Syndrome 2013 5:75

    Content type: Research

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  40. Body mass index (BMI) and waist circumference (WC) are the most used anthropometric measures to identify obesity. While BMI is considered to be a simple and accurate estimate of general adiposity, WC is an alt...

    Authors: Márcio Weissheimer Lauria, Lívia Maria Pinheiro Moreira, George Luiz Lins Machado-Coelho, Raimundo Marques do Nascimento Neto, Maria Marta Sarquis Soares and Adauto Versiani Ramos

    Citation: Diabetology & Metabolic Syndrome 2013 5:74

    Content type: Research

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  41. The purpose of this study was to explore the extent of associations of cardiovascular autonomic neuropathy (CAN) with metabolic syndrome (MetS) and resting heart reate (HR), and to evaluate the predictive valu...

    Authors: Yu Lu, Zi-Hui Tang, Fangfang Zeng, Yiming Li and Linuo Zhou

    Citation: Diabetology & Metabolic Syndrome 2013 5:73

    Content type: Research

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  42. Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute ...

    Authors: Justin R Ryder, Sonia Vega-López, Constantine S Djedjos and Gabriel Q Shaibi

    Citation: Diabetology & Metabolic Syndrome 2013 5:72

    Content type: Short report

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  43. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among Chinese children and adolescents. Moreover, to determine...

    Authors: Jinhua Yin, Ming Li, Lu Xu, Ying Wang, Hong Cheng, Xiaoyuan Zhao and Jie Mi

    Citation: Diabetology & Metabolic Syndrome 2013 5:71

    Content type: Research

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  44. Metformin treatment has been the most recommended monotherapy of type 2 diabetes mellitus (T2DM) for decades but is challenged by new antidiabetic drugs. This study conducted a meta-analysis of randomized cont...

    Authors: Hongmei Zhu, Shuang Zhu, Xiuqian Zhang, Yang Guo, Yunzhen Shi, Zhimin Chen and Siu-wai Leung

    Citation: Diabetology & Metabolic Syndrome 2013 5:70

    Content type: Research

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  45. It is unclear if the sugar intake may affect metabolic parameters in individuals with type 1 diabetes. Therefore, the purpose of this study was to evaluate the effects of sucrose intake in glycemic, lipemic, a...

    Authors: Débora Lopes Souto, Lenita Zajdenverg, Melanie Rodacki and Eliane Lopes Rosado

    Citation: Diabetology & Metabolic Syndrome 2013 5:67

    Content type: Research

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