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  1. In addition to their role in growth, cellular differentiation and homeostasis Retinoid X Receptors (RXR) regulate multiple physiological and metabolic pathways in various organs that have beneficial glucose an...

    Authors: Manoj Kumar Sadasivuni, Bobbili Madhusudhan Reddy, Jaideep Singh, Mammen O Anup, Venkategowda Sunil, Mudigere N Lakshmi, Sivakumaran Yogeshwari, Suni K Chacko, Talanki Lokesh Pooja, Anilkumar Dandu, Chandrashekaran Harish, Aralakuppe S Gopala, Shivakumar Pratibha, Baisani S Naveenkumar, Puttrevana M Pallavi, Mahesh Kumar Verma…

    Citation: Diabetology & Metabolic Syndrome 2014 6:83

    Content type: Research

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  2. Cardiac autonomic neuropathy (CAN) is a common complication of type 2 diabetes mellitus (T2DM). Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of vascular damages. The goal o...

    Authors: Nan Wu, Xiaoling Cai, Kuanping Ye, Yintao Li, Min He, Weiwei Zhao and Renming Hu

    Citation: Diabetology & Metabolic Syndrome 2014 6:82

    Content type: Research

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  3. Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced...

    Authors: Marilia Brito Gomes and Carlos Antonio Negrato

    Citation: Diabetology & Metabolic Syndrome 2014 6:80

    Content type: Research

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  4. Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interac...

    Authors: Omar Jamal, Ehimen C Aneni, Sameer Shaharyar, Shozab S Ali, Don Parris, John W McEvoy, Emir Veledar, Michael J Blaha, Roger S Blumenthal, Arthur S Agatston, Raquel D Conceição, Theodore Feldman, Jose A Carvalho, Raul D Santos and Khurram Nasir

    Citation: Diabetology & Metabolic Syndrome 2014 6:79

    Content type: Research

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  5. Low levels of serum 25–hydroxy vitamin D (25(OH)D), have been associated with development of type 2 diabetes and cardiovascular disease (CVD); however there are limited data on serum 25(OH)D in Indigenous Aust...

    Authors: Louise J Maple-Brown, Jaquelyne T Hughes, Zhong X Lu, Kanakamani Jeyaraman, Paul Lawton, Graham RD Jones, Andrew Ellis, Ashim Sinha, Alan Cass, Richard J MacIsaac, George Jerums and Kerin O’Dea

    Citation: Diabetology & Metabolic Syndrome 2014 6:78

    Content type: Research

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  6. This study aimed to evaluate the role of acanthosis nigricans (AN) as a marker of Type 2 Diabetes Mellitus (T2DM) by studying its prevalence and relationship with age, ethnicity, anthropometry and other risk f...

    Authors: Sarasvati Bahadursingh, Catherine Mungalsingh, Terence Seemungal and Surujpal Teelucksingh

    Citation: Diabetology & Metabolic Syndrome 2014 6:77

    Content type: Research

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  7. Glycemic variability (GV) still remains unclear whether acute glycemic excursion has the important prognostic significance in ST-segment elevation myocardial infarction (STEMI) patients undergoing p-PCI. So ou...

    Authors: Jian-wei Zhang, Ling-jie He, Shu-jun Cao, Qing Yang, Shi-wei Yang and Yu-jie Zhou

    Citation: Diabetology & Metabolic Syndrome 2014 6:76

    Content type: Research

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  8. Early identification of high-risk individuals is key for the prevention of cardiovascular disease (CVD). The aim of this study was to assess the potential impact of a family history of metabolic syndrome (fhMe...

    Authors: Anna Lipińska, Magdalena Koczaj-Bremer, Krzysztof Jankowski, Agnieszka Kaźmierczak, Michał Ciurzyński, Aisha Ou-Pokrzewińska, Ewelina Mikocka, Zbigniew Lewandowski, Urszula Demkow and Piotr Pruszczyk

    Citation: Diabetology & Metabolic Syndrome 2014 6:75

    Content type: Research

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  9. To test the effectiveness of a dance program to improve fitness and adherence to physical activity in subjects with type 2 diabetes and obesity.

    Authors: Felice Mangeri, Luca Montesi, Gabriele Forlani, Riccardo Dalle Grave and Giulio Marchesini

    Citation: Diabetology & Metabolic Syndrome 2014 6:74

    Content type: Research

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  10. To compare the first-in-class sodium glucose co-transporter 2 (SGLT2) inhibitor, dapagliflozin, with existing type 2 diabetes mellitus (T2DM) treatment options available within the European Union (EU) for add-...

    Authors: Michelle Orme, Peter Fenici, Isabelle Duprat Lomon, Gail Wygant, Rebecca Townsend and Marina Roudaut

    Citation: Diabetology & Metabolic Syndrome 2014 6:73

    Content type: Review

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  11. Insulin resistance (IR) is closely correlated with cardiovascular disease (CVD). Retinol-binding protein 4 (RBP4) is a novel adipokine that modulates the action of insulin in various diseases. This study addre...

    Authors: Wuquan Deng, Yuping Zhang, Yanling Zheng, Youzhao Jiang, Qinan Wu, Ziwen Liang, Gangyi Yang and Bing Chen

    Citation: Diabetology & Metabolic Syndrome 2014 6:72

    Content type: Research

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  12. The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-...

    Authors: Mei-Fang Li, Ying Ren, Cui-Chun Zhao, Rong Zhang, Lian-Xi Li, Fang Liu, Jun-Xi Lu, Yin-Fang Tu, Wei-Jing Zhao, Yu-Qian Bao and Wei-Ping Jia

    Citation: Diabetology & Metabolic Syndrome 2014 6:71

    Content type: Research

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  13. Elevated serum free fatty acids (FFAs) contribute to the pathogenesis of type-2-diabetes (T2D), and lipotoxicity is observed in many cell types. We recently showed that simulated hyperlipidemia induces lipoapo...

    Authors: Camilla Kappe, Qimin Zhang, Thomas Nyström and Åke Sjöholm

    Citation: Diabetology & Metabolic Syndrome 2014 6:70

    Content type: Research

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  14. The oral DPP-4 inhibitors are new incretin-based therapies for treatment of type 2 diabetes. To assess the efficacy and safety of three DPP-4 inhibitors (Saxagliptin, Sitagliptin and Vildagliptin) as add-on th...

    Authors: Chun-Jun Li, Xiao-Juan Liu, Lian Bai, Qian Yu, Qiu-Mei Zhang, Pei Yu and De-Min Yu

    Citation: Diabetology & Metabolic Syndrome 2014 6:69

    Content type: Research

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  15. This study aimed to explore parameters which will predict good control of HbA1c after adding a second anti-diabetic drug in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin mon...

    Authors: Po-Hsun Chen, Yi-Ting Tsai, Jun-Sing Wang, Shi-Dou Lin, Wen-Jane Lee, Shih-Li Su, I-Te Lee, Shih-Te Tu, Yao-Hsien Tseng, Wayne H-H Sheu and Shih-Yi Lin

    Citation: Diabetology & Metabolic Syndrome 2014 6:68

    Content type: Research

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  16. To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D).

    Authors: Marilia Brito Gomes, Carlos Antonio Negrato, Roberta Cobas, Lucianne Righeti Monteiro Tannus, Paolla Ribeiro Gonçalves, Pedro Carlos Barreto da Silva, João Regis Ivar Carneiro, Alessandra Saldanha Mattos Matheus, Sergio Atala Dib, Mirela Jobim Azevedo, Márcia Nery, Melanie Rodacki, Lenita Zajdenverg, Renan Magalhães Montenegro Junior, Janice Sepulveda, Luis Eduardo Calliari…

    Citation: Diabetology & Metabolic Syndrome 2014 6:67

    Content type: Research

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  17. Higher intake of dietary fiber is associated with lower risk of coronary heart disease, the leading cause of mortality among people with type 1 diabetes. The protective effect includes the anti-inflammatory pr...

    Authors: Fernanda S R Bernaud, Mileni Vanti Beretta, Cigléa do Nascimento, Fabrícia Escobar, Jorge L Gross, Mirela J Azevedo and Ticiana C Rodrigues

    Citation: Diabetology & Metabolic Syndrome 2014 6:66

    Content type: Research

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  18. Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with c...

    Authors: Ken Kishida, Yasuhiko Nakagawa, Hironori Kobayashi, Koji Yanagi, Tohru Funahashi and Iichiro Shimomura

    Citation: Diabetology & Metabolic Syndrome 2014 6:64

    Content type: Research

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  19. Previous gestational diabetes mellitus (pGDM) indicates future risk for type 2 diabetes (T2DM). Insulin resistance (IR) may precede T2DM in many years and is associated with an increased risk for cardiovascula...

    Authors: Lenita Zajdenverg, Melanie Rodacki, Janaina Polo Faria, Maria Lúcia Elias Pires, José Egídio Paulo Oliveira and Vera Lúcia Castro Halfoun

    Citation: Diabetology & Metabolic Syndrome 2014 6:63

    Content type: Research

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  20. Increased epicardial adipose tissue thickness and plasma homocysteine levels are associated with Metabolic Syndrome (MS) and coronary artery disease. The majority of patients with MS have subclinical or manife...

    Authors: Akif Serhat Balcioğlu, Murtaza Emre Durakoğlugil, Davran Çiçek, Uğur Abbas Bal, Bülent Boyaci and Haldun Müderrisoğlu

    Citation: Diabetology & Metabolic Syndrome 2014 6:62

    Content type: Research

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  21. There are a few nutritional approaches to address the increased needs of managing diabetic conditions. Previously it has been reported that UP780, a standardized composition of aloe chromone formulated with an...

    Authors: Mesfin Yimam, Jifu Zhao, Brandon Corneliusen, Mandee Pantier, Lidia Brownell and Qi Jia

    Citation: Diabetology & Metabolic Syndrome 2014 6:61

    Content type: Research

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  22. There is a very well known correlation between diabetes and cardiovascular disease but many health care professionals are just concerned with glycemic control, ignoring the paramount importance of controlling ...

    Authors: Marcello Casaccia Bertoluci, Augusto Pimazoni-Netto, Antonio Carlos Pires, Antonio Eduardo Pesaro, Beatriz D Schaan, Bruno Caramelli, Carisi Anne Polanczyk, Carlos Vicente Serrano Júnior, Danielle M Gualandro, Domingos Augusto Malerbi, Emilio Moriguchi, Flavio Antonio de Oliveira Borelli, João Eduardo Nunes Salles, José Mariani Júnior, Luis Eduardo Rohde, Luis H Canani…

    Citation: Diabetology & Metabolic Syndrome 2014 6:58

    Content type: Review

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  23. Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction...

    Authors: Erik Salum, Mark Butlin, Jaak Kals, Mihkel Zilmer, Jaan Eha, Alberto P Avolio, Andres Arend, Marina Aunapuu and Priit Kampus

    Citation: Diabetology & Metabolic Syndrome 2014 6:57

    Content type: Research

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  24. Oxidized low-density lipoprotein (LDL) plays central roles in the formation and progression of atherosclerotic lesions. Malondialdehyde (MDA)-modified LDL (MDA-LDL) is speculated to be generated as a result of...

    Authors: Masami Tanaka, Risa Nishimura, Takeshi Nishimura, Toshihide Kawai, Shu Meguro, Junichiro Irie, Yoshifumi Saisho and Hiroshi Itoh

    Citation: Diabetology & Metabolic Syndrome 2014 6:56

    Content type: Research

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  25. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Platelet-to-lymphocyte ratio (PLR) and neutrophil-...

    Authors: Emin M Akbas, Hikmet Hamur, Levent Demirtas, Eftal M Bakirci, Adalet Ozcicek, Fatih Ozcicek, Ufuk Kuyrukluyildiz and Kultigin Turkmen

    Citation: Diabetology & Metabolic Syndrome 2014 6:55

    Content type: Research

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  26. Hemoglobin A1c is the main treatment target for patients with type 2 diabetes. It has also been shown recently that postprandial glucose and daily glucose fluctuations affect the progression of diabetic compli...

    Authors: Masahiro Yamazaki, Goji Hasegawa, Saori Majima, Kazuteru Mitsuhashi, Takuya Fukuda, Hiroya Iwase, Mayuko Kadono, Mai Asano, Takafumi Senmaru, Muhei Tanaka, Michiaki Fukui and Naoto Nakamura

    Citation: Diabetology & Metabolic Syndrome 2014 6:54

    Content type: Research

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  27. The US Federal and Drug Administration (FDA) recently revised statin drug labels to include the information that increases in fasting serum glucose and glycated haemoglobin levels have been reported with the u...

    Authors: Su May Liew, Ping Yein Lee, Nik Sherina Hanafi, Chirk Jenn Ng, Stalia Siew Lee Wong, Yook Chin Chia, Pauline Siew Mei Lai, Nur Farhana Mohd Zaidi and Ee Ming Khoo

    Citation: Diabetology & Metabolic Syndrome 2014 6:53

    Content type: Research

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  28. Post-transplant diabetes mellitus (PTDM) has been associated with an increased risk of cardiovascular disease (CVD) mortality following kidney transplantation, but the association between pre-diabetes (i.e. im...

    Authors: Andrea Viecelli, Hung T Do Nguyen, Kenneth Yong, Doris Chan, Gursharan Dogra, Germaine Wong and Wai H Lim

    Citation: Diabetology & Metabolic Syndrome 2014 6:52

    Content type: Research

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  29. The vascular complications of outpatients with diabetes at ordinary hospitals vary. Ischemic heart disease is barely predictable after treatment using previously reported therapeutic indices. We developed a si...

    Authors: Tadafumi Kajimoto, Mami S Sawamura, Reiko D Hayashi, Takeshi Oya, Rieko A Hirao and Haruhiko Kouhara

    Citation: Diabetology & Metabolic Syndrome 2014 6:51

    Content type: Research

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  30. Obesity is a known risk factor for type 2 diabetes (T2D). We conducted a case–control study to assess the association between body mass index (BMI) and the risk of being diagnosed with T2D in the United States.

    Authors: Michael L Ganz, Neil Wintfeld, Qian Li, Veronica Alas, Jakob Langer and Mette Hammer

    Citation: Diabetology & Metabolic Syndrome 2014 6:50

    Content type: Research

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  31. Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammati...

    Authors: Ching-Jung Hsieh, Pei-Wen Wang and Tse-Ying Chen

    Citation: Diabetology & Metabolic Syndrome 2014 6:49

    Content type: Research

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  32. Combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) is effective for the treatment of type 2 diabetes (T2DM) that cannot be adequately controlled using OHAs alone. Though basal ...

    Authors: Noriko Ihana, Tetsuro Tsujimoto, Ritsuko Yamamoto-Honda, Miyako Kishimoto, Hiroshi Kajio, Hiroshi Noto, Masafumi Kakei and Mitsuhiko Noda

    Citation: Diabetology & Metabolic Syndrome 2014 6:48

    Content type: Research

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  33. The inappropriate secretion of adipocytokines plays a critical role in chronic inflammatory states associated with obesity-linked type 2 diabetes and atherosclerosis. The pleiotropic actions of simvastatin and...

    Authors: Adriana Ferreira Grosso, Sérgio Ferreira de Oliveira, Maria de Lourdes Higuchi, Desidério Favarato, Luís Alberto de Oliveira Dallan and Protásio Lemos da Luz

    Citation: Diabetology & Metabolic Syndrome 2014 6:47

    Content type: Research

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  34. Coronary artery disease (CAD) is the leading cause of death among individuals with type 2 diabetes (T2DM). T2DM accelerates atherosclerosis alongside classical risk factors such as dyslipidemia and hypertensio...

    Authors: Célia Bittencourt, Valdecira M Piveta, Carolina SV Oliveira, Felipe Crispim, Deyse Meira, Pedro Saddi-Rosa, Fernando MA Giuffrida and André F Reis

    Citation: Diabetology & Metabolic Syndrome 2014 6:46

    Content type: Research

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  35. Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. The available drugs are not suff...

    Authors: Bhagat Singh, Ganesh V Sangle, Jeya Murugan, Rinku Umrani, Subhasis Roy, Onkar Kulkarni, Arvind Semwal, MK Unnikrishnan and Mukul Jain

    Citation: Diabetology & Metabolic Syndrome 2014 6:45

    Content type: Research

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  36. Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF pop...

    Authors: An LM Stevens, Dominique Hansen, Vincent Vandoren, Rob Westerlaken, An Creemers, Bert O Eijnde and Paul Dendale

    Citation: Diabetology & Metabolic Syndrome 2014 6:44

    Content type: Research

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  37. There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this as...

    Authors: Francis M Finucane, Stephen J Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J Griffin and Nicholas J Wareham

    Citation: Diabetology & Metabolic Syndrome 2014 6:43

    Content type: Research

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  38. The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal mo...

    Authors: Cristina Mega, Helena Vala, Paulo Rodrigues-Santos, Jorge Oliveira, Frederico Teixeira, Rosa Fernandes, Flávio Reis and Edite Teixeira de Lemos

    Citation: Diabetology & Metabolic Syndrome 2014 6:42

    Content type: Research

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  39. To observe the efficacy and safety of adding glimepiride to established insulin therapy in poorly controlled type 2 diabetes (T2D) and to assess the relationship of changes in the serum high-molecular weight (...

    Authors: Chun-Jun Li, Jing-Yun Zhang, De-Min Yu and Qiu-Mei Zhang

    Citation: Diabetology & Metabolic Syndrome 2014 6:41

    Content type: Research

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  40. To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body we...

    Authors: Petri K Wiklund, Satu Pekkala, Reija Autio, Eveliina Munukka, Leiting Xu, Juha Saltevo, ShuMei Cheng, Urho M Kujala, Markku Alen and Sulin Cheng

    Citation: Diabetology & Metabolic Syndrome 2014 6:40

    Content type: Research

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  41. Both low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), ...

    Authors: Lena M Håglin, Birgitta Törnkvist and Lennart O Bäckman

    Citation: Diabetology & Metabolic Syndrome 2014 6:39

    Content type: Research

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  42. The frequency of Type 1 diabetes (T1D)-related autoantibodies was determined in children with autoimmune hepatitis. However, the incidence of autoimmune hepatitis related autoantibodies in children with T1D ha...

    Authors: Abdulrahman A Al-Hussaini, Musa D Alzahrani, Ahmed S Alenizi, Nimer M Suliman, Mannan A Khan, Sahar A Alharbi and Aziz A Chentoufi

    Citation: Diabetology & Metabolic Syndrome 2014 6:38

    Content type: Research

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  43. Premixed insulin regimens are commonly used for the treatment of patients with type-2 diabetes mellitus (T2DM). However, limited data are available regarding next-step therapy options in cases where premixed i...

    Authors: Ying Zhang, Yi-juan Xie, Dong-dong Meng, Hao-hang Zhang, Hui Chen and En Liu

    Citation: Diabetology & Metabolic Syndrome 2014 6:37

    Content type: Research

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  44. Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise...

    Authors: Rune Byrkjeland, Elisabeth Edvardsen, Ida Unhammer Njerve, Harald Arnesen, Ingebjørg Seljeflot and Svein Solheim

    Citation: Diabetology & Metabolic Syndrome 2014 6:36

    Content type: Research

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  45. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is currently used to achieve glycemic targets in patients with type 2 diabetes mellitus (T2DM). The addition of DPP-4 inhibitors to ongoing insulin ther...

    Authors: Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Tomio Onuma, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Kazunari Matsumoto, Hiroki Yokoyama, Mamiko Tsugawa, Masahiko Gosho, Iichiro Shimomura…

    Citation: Diabetology & Metabolic Syndrome 2014 6:35

    Content type: Research

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  46. Stem cell therapy holds a great promise for the repair of injured tissues and organs, including the kidney. We studied the effect of mesenchymal stem cells (MSC) on experimental diabetic nephropathy (DN) in ra...

    Authors: Mohamed Talaat Abdel Aziz, Mohamed Abdel Aziz Wassef, Hanan Hosni Ahmed, Laila Rashed, Soheir Mahfouz, Mayssa Ibrahim Aly, Rania Elsayed Hussein and Mai Abdelaziz

    Citation: Diabetology & Metabolic Syndrome 2014 6:34

    Content type: Research

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