Articles

Metabolites of gut microbiome are associated with glucose metabolism in non-diabetic obese adults: a Chinese monozygotic twin study

Evidence suggests gut microbiome is associated with diabetes. However, it’s unclear whether the association remains in non-diabetic participants. A Chinese monozygotic twin study, in which the participants are...

Authors: Ke Yu, Cai-Guo Yu, Xing-Qi Yin, Zong-Wei Wang, Xiao-Bo Wang, Li-Li Wang, Shuang Guo, Ya-Xin An and Dong Zhao

Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway

Hyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR and RhoA/ROCK signaling pathways are involved in glomerular filtration ...

Authors: Xiaolin Chen, Jianhui Chen, Xianfan Li and Zengpu Yu

Use of continuous glucose monitoring system in patients with type 2 mellitus diabetic during hemodialysis treatment

Studies highlight the inaccuracy of glycated hemoglobin (HbA1c) for the assessment of glycemic control in dialysis diabetics and suggest the use of continuous glucose monitoring (CGM) as an alternative. Of the...

Authors: Marcelo Rocha Nasser Hissa, Priscilla Nogueira Gomes Hissa, Sérgio Botelho Guimarães and Miguel Nasser Hissa

Impact of prediabetes on long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries

Abnormal glucose metabolism including diabetes (DM) and prediabetes (pre-DM) have been reported as predictors of poorer outcomes after acute myocardial infarction (AMI). However, the prognostic value of pre-DM...

Authors: Side Gao, Wenjian Ma, Sizhuang Huang, Xuze Lin and Mengyue Yu

Association of sleep quality with glycemic variability assessed by flash glucose monitoring in patients with type 2 diabetes

Deterioration of sleep quality has been reported to contribute to the incidence of diabetes and may be responsible for glycemic status in diabetes. The present study explored the relationship between sleep qua...

Authors: Yang Yang, Li-hua Zhao, Dan-dan Li, Feng Xu, Xiao-hua Wang, Chun-feng Lu, Chun-hua Wang, Chao Yu, Xiu-lin Zhang, Li-yan Ning, Xue-qin Wang, Jian-bin Su and Li-hua Wang

HbA1C variability among type 2 diabetic patients: a retrospective cohort study

Studies have found that HbA1C variability is an independent risk factor for diabetic complications in type 2 diabetic patients. This study aims to find factors contributing to higher HbA1C variability in the c...

Authors: Dikla Akselrod, Michael Friger and Aya Biderman

Serum albumin was negatively associated with diabetic peripheral neuropathy in Chinese population: a cross-sectional study

Previous studies that explored the relationship of serum albumin with diabetic peripheral neuropathy (DPN) have indicated inconsistent results. Thus, the present study aimed to evaluated the association betwee...

Authors: Pijun Yan, Qian Tang, Yuru Wu, Qin Wan, Zhihong Zhang, Yong Xu, Jianhua Zhu and Ying Miao

Advances in GLP-1 treatment: focus on oral semaglutide

There is currently a large arsenal of antidiabetic drugs available to treat type 2 diabetes (T2D). However, this is a serious chronic disease that affects millions of adults worldwide and is responsible for se...

Authors: Freddy G. Eliaschewitz and Luis Henrique Canani

Resistin levels and inflammatory and endothelial dysfunction markers in obese postmenopausal women with type 2 diabetes mellitus

Obesity-associated coronary heart disease (CHD) risk is higher in women than in men with type 2 diabetes (T2DM). Resistin, an adipokine secreted by adispose tissue, may contribute to this higher risk.

Authors: A. Giandalia, A. Alibrandi, L. Giorgianni, F. Lo Piano, F. Consolo, G. Longo Elia, B. Asztalos, D. Cucinotta, G. Squadrito and G. T. Russo

Diagnostic significance of serum lncRNA HOTAIR and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) affects the social economy and quality of life, and has become a major threat to human health. This observation aimed to study the possibility of serum HOTAIR as a diagnostic in...

Authors: Huiyun Wang, Yu Xia and Yanxia Zhang

Clinical and genetic features of maturity-onset diabetes of the young in pediatric patients: a 12-year monocentric experience

A retrospective observational study was conducted to assess the prevalence of maturity onset diabetes of the young (MODY) in a large paediatric population of Southern Italy newly diagnosed with diabetes. Clini...

Authors: Stefano Passanisi, Giuseppina Salzano, Bruno Bombaci and Fortunato Lombardo

Impact of COVID-19 lockdown on glycemic control in patients with type 1 and type 2 diabetes mellitus: a systematic review

In 2019, a new virus known as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has emerged. Coronavirus disease 2019 (COVID-19) was classified as a pandemic in a short period of time. In order...

Authors: Claudia Eberle and Stefanie Stichling

Correlation between short- and mid-term hemoglobin A1c and glycemic control determined by continuous glucose monitoring

Glucose monitoring is vital for glycemic control in patients with diabetes mellitus (DM). Continuous glucose monitoring (CGM) measures whole-day glucose levels. Hemoglobin A1c (HbA1c) is a vital outcome predic...

Authors: Jen-Hung Huang, Yung-Kuo Lin, Ting-Wei Lee, Han-Wen Liu, Yu-Mei Chien, Yu-Chun Hsueh, Ting-I Lee and Yi-Jen Chen

The prevalence and risk factors of sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Sarcopenia was a frequent chronic complication in patients with type 2 diabetes mellitus (T2DM), and previous evidence showed conflicting results regarding the prevalence and risk factors of sarcopenia in T2DM...

Authors: Yaqin Ai, Ruoxin Xu and Lingping Liu

A potent weighted risk model for evaluating the occurrence and severity of diabetic foot ulcers

Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes. This study aimed to establish weighted risk models for determining DFU occurrence and severity in diabetic patients.

Authors: Lu Shi, Huiyi Wei, Tianxiao Zhang, Zhiying Li, Xiaoxian Chi, Dandan Liu, Dandan Chang, Yueying Zhang, Xiaodan Wang and Qingbin Zhao

A novel mutation KCNJ11 R136C caused KCNJ11-MODY

A young female patient, diagnosed with diabetes mellitus at the age of 28 years old in 2009, carries KCNJ11 R136C by whole exome sequencing and her daughter doesn’t carry this mutation. Bioinformatics software pr...

Authors: Yaning Chen, Xiaodong Hu, Jia Cui, Mingwei Zhao and Hebin Yao

Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases; however, there has been little research into its impact on gestational diabetes mellitus (GDM).

Authors: Sang Youn You, Kyungdo Han, Seung-Hawn Lee and Mee Kyoung Kim

Long non-coding RNA CASC2 restrains high glucose-induced proliferation, inflammation and fibrosis in human glomerular mesangial cells through mediating miR-135a-5p/TIMP3 axis and JNK signaling

Diabetic nephropathy (DN) is a common complication of diabetes. Long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is reported to exert a protective role in DN by a previous study. The work...

Authors: Dongju Zhu, Xiang Wu and Qian Xue

Association between dipeptidyl peptidase-4 inhibitors use and leptin in type 2 diabetes mellitus

Dipeptidyl peptidase-4 inhibitors (DPP-4i) provide a unique antihyperglycemic effect by regulating incretin peptides in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled with insulin the...

Authors: Xin Wei, Yu Bai, Zhuo Wang, Xiaohong Zheng, Zening Jin and Xin Liu

Diabetes self-care practices and resilience in the Brazilian COVID-19 pandemic: results of a web survey: DIABETESvid

The world guidance on the measures of social distancing for prevention of COVID-19 has changed the daily habits of great part of the population, and this could influence the care and resilience with diabetes d...

Authors: Bárbara Aparecida Binhardi, Carla Regina de Souza Teixeira, Bianca de Almeida-Pititto, Francisco Barbosa-Junior, Laercio Joel Franco, Karla Fabiana Santana de Melo, Domingos Augusto Cherino Malerbi and Rinaldo Eduardo Machado de Oliveira

Microvascular complications and its predictors among type 2 diabetes mellitus patients at Dessie town hospitals, Ethiopia

Diabetes mellitus is a serious metabolic disorder which becomes common in middle and low incomes countries since few decades. Microvascular complications include retinopathy, neuropathy and nephropathy all of ...

Authors: Mohammed Abdu Seid, Yonas Akalu, Yibeltal Yismaw Gela, Yitayeh Belsti, Mengistie Diress, Sofonias Addis Fekadu, Baye Dagnew and Mihret Getnet

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis

1,5-anhydroglucitol is a reduction product of 1,5-anhydrofructose. Circulating 1,5-anhydroglucitol is usually excreted by the kidneys and is reabsorbed via sodium-glucose co-transporter 4 in the renal tubules....

Authors: Kenji Tanaka, Akiko Sakasai-Sakai, Yasuki Motomiya, Tatsuo Yoneda and Masayoshi Takeuchi

Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis

Diabetes mellitus (DM) causes excess risk of fracture at varied sites. Whereas, the difference between the roles of types 1 DM (T1DM) and 2 DM (T2DM) diabetes in the risk of fractures remains limited and incon...

Authors: Jiaqing Dou, Jing Wang and Qiu Zhang

Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

Although the well-established role of the HLA genes on the predisposition of type 1 diabetes (T1D), its contribution to the development and progression of diabetic retinopathy is still unclear, especially in a...

Authors: Deborah Conte Santos, Luís Cristóvão Porto, Marcela Haas Pizarro, Laura Gomes Nunes de Melo, Dayse A. Silva, Romulo Vianna Oliveira, Anna Paula Villela, Luiza Harcar Muniz, Camila Soares, Lucianne Righeti Monteiro Tannus, Karla Rezende Guerra Drummond, André Araújo Pinheiro, Felipe Mallmann, Franz Schubert Lopes Leal, Fernando Korn Malerbi, Paulo Henrique Morales…

Anthropometric indices and the risk of incident sudden cardiac death among adults with and without diabetes: over 15 years of follow-up in The Tehran Lipid and Glucose Study

We investigated the association of anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and hip circumference (HC) with the ...

Authors: Seyyed Saeed Moazzeni, Seyed Saeed Tamehri Zadeh, Samaneh Asgari, Fereidoun Azizi and Farzad Hadaegh

Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results: can definition of established cardiovascular disease be the missing link?

Atherosclerotic cardiovascular diseases are the leading cause of adverse outcomes in patients with type 2 diabetes, and all new anti-diabetic agents are mandated to undergo cardiovascular outcome trials (CVOTs...

Authors: Miguel Melo, Cristina Gavina, José Silva-Nunes, Luís Andrade and Davide Carvalho

Metabolic control and hypoglycaemia in people with type 1 diabetes: insulin pump therapy vs. intensified insulin therapy in an unselected cohort in routine care

The aim of this study was to compare individuals with type 1 diabetes with continuous subcutaneous insulin infusion (CSII) and intensified insulin therapy (ICT) in routine care regarding metabolic control and ...

Authors: Guido Kramer, Christof Kloos, Ulrich A. Müller, Gunter Wolf and Nadine Kuniss

Overweight and obesity in type 1 diabetes is not associated with higher ghrelin concentrations

Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensive...

Authors: Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers and Aart Jan van der Lely

Correction to: Cross-national comparison of psychosocial well-being and diabetes outcomes in adults with type 1 diabetes during the COVID-19 pandemic in US, Brazil, and Iran

Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafee Vardanjani, Kobra Noorian and Danielle Hessler

Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients

To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients.

Authors: Jianguo Liu, Liehui Xiao, Hezhongrong Nie, Yong Pan, Yan Liu, Zhentian Zhang, Xiuping Lin, Yuan Zhang, Jinchuang Cai, Muxiu Yang, Yajing Liu, Leijun Zhang, Aimin Xu and Cuifeng Zhu

Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapies

COVID-19 has stroke Brazil harshly, deaths by COVID-19 in Brazil represent almost 13% of the total deaths by COVID-19 in the world, even though Brazilian population represents only 2.6% of the world population...

Authors: Rodrigo Esaki Tamura, Said Muhammad Said, Leticia Mussin de Freitas and Ileana Gabriela Sanchez Rubio

Effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus: An updated meta-analysis

Previous studies have analyzed the potential effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus, but the findings are inconclusive and the subject of debate. The purpose of o...

Authors: Hong-Liang Jiang, Han Du, Ying-Jun Deng and Xue Liang

Oxidative phenotype induced by aerobic physical training prevents the obesity-linked insulin resistance without changes in gastrocnemius muscle ACE2-Angiotensin(1-7)-Mas axis

We investigate the effect of aerobic physical training (APT) on muscle morphofunctional markers and Angiotensin Converting Enzyme 2/Angiotensin 1-7/Mas receptor (ACE2/Ang 1-7/Mas) axis in an obesity-linked ins...

Authors: Bruno Vecchiatto, Rafael C. da Silva, Talita S. Higa, Cynthia R. Muller, Anna Laura V. Américo, Vanessa C. Fortunato-Lima, Marília M. Ferreira, Luiz Felipe Martucci, Miriam H. Fonseca-Alaniz and Fabiana S. Evangelista

Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus

Pregnant women with a history of gestational diabetes mellitus (GDM) are at high risk of GDM. It is unclear whether this population has pregnancy characteristics different from the general population. Whether ...

Authors: Xin Liang, Wei Zheng, Cheng Liu, Lirui Zhang, Li Zhang, Zhihong Tian and Guanghui Li

Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

Circular RNAs (circRNAs) have been considered as pivotal biomarkers in Diabetic nephropathy (DN). CircRNA ARP2 actin-related protein 2 homolog (circ-ACTR2) could promote the HG-induced cell injury in DN. Howev...

Authors: Jie Yun, Jinyu Ren, Yufei Liu, Lijuan Dai, Liqun Song, Xiaopeng Ma, Shan Luo and Yexu Song

Arterial stiffness and progression of cerebral white matter hyperintensities in patients with type 2 diabetes and matched controls: a 5-year cohort study

Stroke is a serious complication in patients with type 2 diabetes (T2DM). Arterial stiffness may improve stroke prediction. We investigated the association between carotid-femoral pulse wave velocity [PWV] and...

Authors: Kristian L. Funck, Esben Laugesen, Pernille Høyem, Brian Stausbøl-Grøn, Won Y. Kim, Leif Østergaard, Dora Grauballe, Troels K. Hansen, Christian S. Buhl and Per L. Poulsen

Serum fatty acid-binding protein 4 levels and responses of pancreatic islet β-cells and α-cells in patients with type 2 diabetes

Serum fatty acid-binding protein 4 (FABP4), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its associati...

Authors: Hong Wang, Jie Cao, Jian-bin Su, Xue-qin Wang, Xing Wang, Dong-mei Zhang and Xiao-hua Wang

Protection of coenzyme Q10 against contrast-induced acute kidney injury in male diabetic rats

Diabetes mellitus (DM) is a major risk factor for contrast-induced acute kidney injury (CI-AKI). DM and CI-AKI result in oxidative damage and inflammation that can be reduced when treated with the coenzyme Q-1...

Authors: Sheila Marques Fernandes Couto, Cassiane Dezoti da Fonseca, Mirian Watanabe and Maria de Fátima Fernandes Vattimo

Exploring early combination strategy in Latin American patients with newly diagnosed type 2 diabetes: a sub-analysis of the VERIFY study

Patients with type 2 diabetes mellitus (T2DM) from Latin American countries face challenges in access to healthcare, leading to under-diagnosis, under-achievement of glycemic target, and long-term complication...

Authors: Sérgio Vencio, Juan P. Manosalva, Chantal Mathieu, Pieter Proot, Hernan Yupanqui Lozno and Päivi M. Paldánius

Correction to: Improvements in cholesterol efux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity

An amendment to this paper has been published and can be accessed via the original article.

Authors: Himani Thakkar, Vinnyfred Vincent, Sakshi Shukla, Manraj Sra, Uma Kanga, Sandeep Aggarwal and Archna Singh

Performance of waist-to-height ratio as a screening tool for identifying cardiometabolic risk in children: a meta-analysis

To provide the latest evidence of performance and robustness of waist-to-height ratio (WHtR) in discriminating clusters of cardiometabolic risk factors (CMRs) and promote WHtR in routine primary health care pr...

Authors: Yuan Jiang, Yalan Dou, Hongyan Chen, Yi Zhang, Xiaotian Chen, Yin Wang, Myanca Rodrigues and Weili Yan

SARS-COV-2 infection outcomes in patients with congenital generalized lipodystrophy

A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients gener...

Authors: Mayara Ponte Madeira, Erika Bastos Lima Freire, Virginia Oliveira Fernandes, Grayce Ellen da Cruz Paiva Lima, Ivana da Ponte Melo, Ana Paula Dias Rangel Montenegro, José Ednésio da Cruz Freire, Caroline de Fátima Aquino Moreira-Nunes, Raquel Carvalho Montenegro, Jeová Keny Baima Colares and Renan Magalhães Montenegro Junior

Pens versus syringes to deliver insulin among elderly patients with type 2 diabetes: a randomized controlled clinical trial

Diabetes mellitus (DM) is a prevalent disease among elderly population. As the disease progresses, insulin may become necessary. The use of pens application seems to be more practical. However, the influence o...

Authors: Rafael Vaz Machry, Gustavo Fonseca Cipriani, Henrique Umpierre Pedroso, Rafaela Ramos Nunes, Thayme Luisa Souza Pires, Raquel Ferreira, Betina Vescovi, Gabriela Pereira de Moura and Ticiana Costa Rodrigues

Cross-national comparison of psychosocial well-being and diabetes outcomes in adults with type 1 diabetes during the COVID-19 pandemic in US, Brazil, and Iran

The COVID-19 pandemic is a global public health emergency, which presents wide-ranging negative impacts on individuals with diabetes. To examine psychosocial well-being and diabetes outcomes in individuals wit...

Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafiee Vardanjani, Kobra Noorian and Danielle Hessler

Effects of short-term dietary restriction on plasma metabolites and the subcutaneous fat area according to metabolic status in obese individuals: a case–control study

Research elucidating the metabolic mechanisms that differentiate subtypes of obesity has been increasing. We aimed to investigate the effects of a 12-week dietary intervention on the metabolomic profiles of ob...

Authors: Hye Yoon Jang, Youngmin Han, Hye Jin Yoo, Jong Ho Lee and Minjoo Kim

The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio

Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years. The effect...

Authors: Shatha Rouf Moustafa

The association of laminin levels with insulin resistance and non-alcoholic hepatosteatosis

Laminin, one of the largest glycoproteins of the basement membrane, is an important component of the extracellular matrix. Functions of the basement membrane include regulation of cell signaling behaviors and ...

Authors: Özgür Altun, Yücel Arman, Şengül Aydın Yoldemir, Ayşe Selcen Pala, Perihan Özkan Gümüşkaya, Mustafa Özcan, Mustafa Karataş, Okan Dikker and Tufan Tükek

Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study

To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups.

Authors: Jia Y. Wan, Deborah L. Goodman, Emileigh L. Willems, Alexis R. Freedland, Trina M. Norden-Krichmar, Stephanie A. Santorico and Karen L. Edwards

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patie...

Authors: Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao and Ze-nan Tang

Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats

Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training ...

Authors: Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari and Hassan Tavassoli