Fig. 3
From: The role of wnt signaling in diabetes-induced osteoporosis
Hyperglycemia promotes adipocytogenesis in ST2 cells and BMSCs, as well as stimulates osteoclastogenesis in RAW264.7 cells and BMMs, by inhibiting canonical Wnt signaling
Hyperglycemia-induced decreased expression of Wnt1, Wnt3a, Wnt10b, LRP5/6 and FZD4, and increased expression of SOST, DKK-1 and SFRP4, jointly inhibited canonical Wnt signaling in ST2 cells and BMSCs, resulting in the activation of PPARγ and C/EBPα, which triggered increased adipocytogenesis and inhibited bone formation. Hyperglycemia-induced decreased expression of Wnt1, Wnt3a and LRP5/6, and increased expression of SOST, DKK-1 and SFRP4, together inhibited canonical Wnt signaling in RAW264.7 cells and BMMs, which provoked increased osteoclastogenesis and promoted bone resorption
Abbreviations: PPARγ, Peroxisome proliferator-activated receptorγ; C/EBPα, CCAAT/enhancer binding proteinα; RAW264.7 cells, mouse monocyte-macrophage leukemia cell line; BMMs, bone marrow monocyte-macrophage lineage cells