From: Leveraging IgG N-glycosylation to infer the causality between T2D and hypertension
Exposures | SNP (N) | OR (95%CI) (P value) | MR‒Egger (P value) | Weighted median method (P value) | MR‒Egger intercept (P value) |
---|---|---|---|---|---|
Hypertension | 6 | 1.391 (1.081–1.790) (0.010) | 2.018 (0.879–4.637) (0.098) | 1.132 (0.928–1.381) (0.222) | − 0.350 (0.342) |
GP1 | 134 | 1.074 (0.952–1.213) (0.247) | 1.262 (0.985–1.618) (0.066) | 1.112 (0.943–1.311) (0.206) | − 0.122 (0.204) |
GP2 | 37 | 1.435 (1.190–1.731) (1.550 × 10–4) | 1.567 (1.042–2.356) (0.031) | 1.610 (1.174–2.207) (0.003) | − 0.057 (0.635) |
GP3 | 35 | 1.169 (0.932–1.466) (0.177) | 1.618 (1.023–2.557) (0.039) | 1.509 (1.072–2.124) (0.018) | − 0.200 (0.142) |
GP4 | 29 | 1.219 (0.937–1.586) (0.140) | 1.043 (0.584–0.1863) (0.887) | 1.271 (0.848–1.903) (0.246) | 0.100 (0.518) |
GP5 | 62 | 0.819 (0.681–0.984) (0.033) | 1.394 (0.960–2.024) (0.081) | 0.936 (0715–1.227) (0.634) | − 0.317 (0.008) |
GP6 | 24 | 1.498 (1.515–1.950) (0.003) | 2.633 (1.506–4.605) (0.001) | 1.740 (1.115–2.716) (0.015) | − 0.285 (0.056) |
GP7 | 27 | 0.892 (0.655–1.214) (0.466) | 1.590 (0.921–2.744) (0.096) | 0.935 (0.629–1.392) (0.742) | 0.282 (0.060) |
GP8 | 15 | 0.787 (0.546–1.133) (0.197) | 0.748 (0.285–1.964) (0.556) | 0.808 (0.480–1.359) (0.422) | 0.008 (0.965) |
GP9 | 15 | 1.069 (0.618–1.848) (0.811) | 1.546 (0.543–4.403) (0.415) | 0.917 (0.548–1.536) (0.743) | − 0.124 (0.507) |
GP10 | 23 | 0.743 (0.526–1.050) (0.092) | 1.257 (0.637–2.480) (0.510) | 0.704 (0.455–1.091) (0.117) | − 0.256 (0.154) |
GP11 | 17 | 0.936 (0.676–1.298) (0.693) | 1.015 (0.476–2.165) (0.970) | 0.944 (0.571–1.561) (0.823) | − 0.035 (0.828) |
GP12 | 41 | 0.851 (0.659–1.099) (0.216) | 1.216 (0.776–1.904) (0.393) | 0.996 (0.711–1.395) (0.980) | − 0.184 (0.127) |
GP13 | 48 | 0.916 (0.725–1.157) (0.462) | 1.462 (0.975–2.193) (0.066) | 1.010 (0.746–1.367) (0.948) | 0.230 (0.030) |
GP14 | 18 | 0.686 (0.424–1.110) (0.125) | 0.812 (0.273–2.413) (0.707) | 0.678 (0.369–1.246) (0.211) | − 0.064 (0.767) |
GP15 | 17 | 0.560 (0.384–0.816) (0.003) | 1.313 (0.436–3.953) (0.628) | 0.602 (0.357–1.016) (0.057) | − 0.349 (0.153) |
GP16 | 25 | 1.124 (0.860–1.468) (0.394) | 1.138 (0.530–2.447) (0.740) | 1.148 (0.777–1.697) (0.488) | − 0.007 (0.962) |
GP17 | 53 | 0.889 (0.727–1.087) (0.251) | 1.517 (1.044–2.204) (0.029) | 1.014 (0.754–1.363) (0.927) | − 0.291 (0.011) |
GP18 | 12 | 1.095 (0.634–1.892) (0.745) | 1.496 (0.464–4.818) (1.496) | 1.423 (0.757–2.674) (0.273) | − 0.156 (0.551) |
GP19 | 22 | 1.286(0.984–1.681) (0.066) | 1.303 (0.717–2.368) (0.385) | 1.405 (0.931–2.122) (0.105) | − 0.017 (0.901) |
GP20 | 62 | 0.857 (0.719–1.022) (0.086) | 0.964 (0.617–1.504) (0.870) | 0.891 (0.691–1.149) (0.374) | − 0.057 (0.731) |
GP21 | 34 | 0.937 (0.725–1.212) (0.621) | 1.204 (0.721–2.011) (0.478) | 0.988 (0.692–1.411) (0.948) | − 0.202 (0.153) |
GP22 | 219 | 1.178 (1.176–1.290) (4.097 × 10–4) | 1.662 (1.270–2.174) (2.134 × 10–4) | 1.253 (1.104–1.422) (4.948 × 10–4) | 0.342 (0.013) |
GP23 | 19 | 1.042 (0.704–1.542) (0.837) | 0.921 (0.427–1.984) (0.833) | 1.074 (0.683–1.689) (0.756) | 0.084 (0.623) |
GP24 | 21 | 1.925 (1.369–2.706) (1.661 × 10–4) | 1.532 (0.539–4.354) (0.424) | 2.182 (1.361–3.498) (0.001) | 0.090 (0.650) |