Table 1 Causal effect estimates on hypertension via Univariable Mendelian randomization

T2D

1.177 (1.037–1.338) (0.012)

1.548 (0.960–2.494) (0.073)

1.142 (0.941–1.387) (0.180)

− 0.384 (0.289)

GP1

0.976 (0.914–1.042) (0.465)

1.054 (0.907–1.224) (0.493)

1.032 (0.929–1.146) (0.554)

− 0.061 (0.327)

GP2

1.113 (0.956–1.297) (0.169)

1.340 (1.005–1.789) (0.046)

1.091 (0.877–1.358) (0.434)

− 0.121 (0.141)

GP3

1.013 (0.851–1.206) (0.887)

1.114 (0.789–1.573) (0.539)

1.146 (0.902–1.456) (0.265)

− 0.097 (0.336)

GP4

1.101 (0.903–1.343) (0.341)

1.290 (0.871–1.911) (0.204)

1.064 (0.806–1.406) (0.661)

− 0.095 (0.382)

GP5

0.987 (0.888–1.096) (0.801)

1.208 (0.969–1.507) (0.094)

1.070 (0.912–1.256) (0.408)

− 0.150 (0.048)

GP6

0.954 (0.787–1.158) (0.635)

0.751 (0.479–0.177) (0.212)

0.960 (0.689–1.339) (0.812)

0.138 (0.198)

GP7

1.091 (0.925–1.287) (0.302)

1.284 (0.913–1.804) (0.150)

1.101 (0.861–1.408) (0.442)

− 0.109 (0.260)

GP8

0.941 (0.709–1.250) (0.675)

0.920 (0.518–1.633) (0.776)

0.832 (0.602–1.151) (0.267)

0.015 (0.897)

GP9

1.210 (0.861–1.699) (0.272)

1.037 (0.383–2.809) (0.944)

1.286 (0.859–1.926) (0.222)

0.063 (0.719)

GP10

0.910 (0.745–1.112) (0.356)

0.712 (0.458–1.105) (0.130)

0.965 (0.729–1.279) (0.806)

0.125 (0.298)

GP11

0.920 (0.732–1.155) (0.472)

0.913 (0.538–1.551) (0.737)

0.958 (0.683–1.345) (0.806)

− 0.008 (0.941)

GP12

0.930 (0.808–1.071) (0.316)

1.151 (0.876–1.514) (0.312)

0.934 (0.758–1.150) (0.518)

− 0.126 (0.106)

GP13

0.970 (0.858–1.096) (0.621)

0.987 (0.776–1.254) (0.912)

0.998 (0.827–1.203) (0.979)

0.008 (0.910)

GP14

0.867 (0.656–1.145) (0.314)

1.104 (0.482–2.528) (0.815)

0.774 (0.514–1.168) (0.223)

− 0.102 (0.525)

GP15

0.775 (0.624–0.964) (0.022)

1.128 (0.626–2.035) (0.689)

0.813 (0.774–1.324) (0.197)

− 0.184 (0.170)

GP16

1.038 (0.868–1.241) (0.687)

0.759 (0.461–1.250) (0.278)

1.012 (0.774–1.324) (0.930)

0.142 (0.164)

GP17

0.828 (0.734–0.934) (0.002)

1.091 (0.855–1.392) (0.483)

0.884 (0.734–1.064) (0.191)

− 0.162 (0.034)

GP18

1.099 (0.815–1.482) (0.537)

1.271 (0.551–2.934) (0.574)

1.165 (0.755–1.798) (0.490)

− 0.059 (0.751)

GP19

0.957 (0.793–1.154) (0.645)

1.040 (0.679–1.592) (0.857)

0.946 (0.712–1.258) (0.704)

− 0.083 (0.401)

GP20

0.833 (0.751–0.923) (5.155 × 10^–4)

0.941 (0.725–1.223) (0.650)

0.845 (0.720–0.992) (0.040)

− 0.112 (0.283)

GP21

1.061 (0.910–1.236) (0.450)

1.351 (0.967–1.887) (0.078)

1.065 (0.848–1.338) (0.588)

− 0.145 (0.122)

GP22

0.903 (0.857–0.952) (1.690 × 10^–4)

1.017 (0.856–1.207) (0.852)

0.970 (0.892–1.055) (0.481)

− 0.105 (0.238)

GP23

1.121 (0.883–1.424) (0.347)

1.599 (0.946–2.702) (0.080)

1.300 (0.941–1.796) (0.111)

− 0.176 (0.137)

GP24

1.148 (0.899–1.466) (0.270)

1.718 (0.898–3.286) (0.102)

1.062 (0.778–1.451) (0.703)

− 0.154 (0.212)