Variable | Group (Before Intervention) Median (IQR) | P-value | Group (After Intervention) Median (IQR) | P-value | Between groups variations Mean difference 95% CI | P-value | P-value (comparison of the groups after intervention) | |||
---|---|---|---|---|---|---|---|---|---|---|
Placebo | Intervention | Placebo | Intervention | Placebo | Intervention | |||||
Weight (kg) | 85.0 (69–100) | 74.0 (69–92) | 0.417b | 80 (68–98) | 72 (68–90) | 0.503b | − 3.35 (− 4.58, − 11.28) | 0.774b |  < 0.001d |  < 0.001d |
SBP (mmHg) | 120 (120–130) | 120 (120–130) | 0.787b | 125 (120–130) | 125 (125–130) | 0.251b | 2.15 (− 1.30, − 5.60) | 0.674b | 0.755d | 0.459c |
DBP (mmHg) | 80 (75–85) | 80 (75–90) | 0.755b | 80 (75–85) | 80 (75–85) | 0.990b | 0.89 (− 3.65, − 5.43) | 0.901b | 0.819d | 0.961d |
FBS (mg/dL) | 107 (104–115) | 107 (104–112) | 0.897b | 95 (88–100) | 96 (89–102) | 0.495b | 1.06 (− 3.70, − 5.82) | 0.764b |  < 0.001d |  < 0.001d |
HbA1C (%) | 5.80 (4.8–6.1) | 5.80 (5.0–5.9) | 0.595b | 5.4 (4.8–5.9) | 5.4 (4.7–5.8) | 0.484b | − 0.2 (− 0.19, 0.59) | 0.972* | 0.133c | 0.035c |
Insulin level (µIU/mL) | 12.2 (6.8–27.1) | 11 (7.6–18.3) | 0.601b | 15.5 (6–25) | 15.5 (8.1–25) | 0.796a | 0.21 (− 12.20, 12.62) | 0.470b | 0.451d | 0.041d |
HOMA-IR | 3.24 (1.91–7.30) | 3.15 (1.93–4.88) | 0.557b | 3.86 (1.51–5.98) | 3.86 (1.82–5.98) | 0.747b | 0.16 (− 2.81, 3.13) | 0.347b |  > 0.999d | 0.235d |
TG(mg/dL) | 144 (105–173) | 148 (130–173) | 0.773a | 110 (84–141) | 117 (91–144) | 0.597b | 15.49 (− 16.13, 47.11) | 0.972b | 0.004c | 0.004c |
LDL(mg/dL) | 114 (91–147) | 112 (91–145) | 0.724a | 99 (84–128) | 96 (84–128) | 0.906b | -2.25 (− 12.05, 16.55) | 0.823b | 0.008c | 0.016c |
HDL(mg/dL) | 46 (40–48) | 46 (39–49) | 0.846b | 50 (43–54) | 49 (42–55) | 0.846b | 0.72 (− 2.68, 4.12) | 0.948b | 0.005d | 0.001d |