Table 2 Association with NT-proBNP and All-cause Mortality in Patients with Ischemic Heart Failure According to Diabetes Mellitus Status

NT-proBNP as continuous variable (Per 1-log NT-proBNP increment)

Event/Total (%)

479/2287 (20.9)

212/1115 (19.0)

267/1172 (22.8)

/

Incidence Rate (100 person-years)

6.6 (6.0-7.2)

5.8 (5.1–6.7)

7.3 (6.5–8.3)

/

Person-Year

7287

3645

3642

/

Model 1 (HR and 95% CI)

1.66 (1.54–1.78)

1.63 (1.36–1.69)

1.77 (1.61–1.96)

0.040

Model 2 (HR and 95% CI)

1.60 (1.48–1.73)

1.47 (1.31–1.66)

1.71 (1.54–1.90)

0.038

Model 3 (HR and 95% CI)

1.46 (1.32–1.61)

1.29 (1.11–1.50)

1.61 (1.40–1.84)

0.042

Model 4 (HR and 95% CI)

1.47 (1.33–1.63)

1.29 (1.11–1.51)

1.65 (1.44–1.90)

0.045

Model 5 (HR and 95% CI)

1.46 (1.31–1.62)

1.28 (1.09–1.50)

1.65 (1.43–1.91)

0.016

NT-proBNP as categorical variable

NT-proBNP categorization

NT-proBNP < 1800 pg/ml

NT-proBNP ≥ 1800 pg/ml

NT-proBNP < 1800 pg/ml

NT-proBNP ≥ 1800 pg/ml

NT-proBNP < 1800 pg/ml

NT-proBNP ≥ 1800 pg/ml

Event/Total (%)

151/1238 (12.2)

328/1049 (31.3)

80/642 (12.5)

132/473 (27.9)

71/596 (11.9)

196/576 (34.0)

/

Incidence Rate (100 person-years)

3.7 (3.1–4.3)

10.4 (9.3–11.5)

3.7 (3.0-4.6)

9.0 (7.6–10.6)

3.6 (2.9–4.6)

11.6 (10.1–13.3)

/

Person-Year

4122

3165

2172

1473

1951

1691

/

Model 1 (HR and 95% CI)

1.00 (Reference)

2.65 (2.18–3.21)

1.00 (Reference)

2.15 (1.62–2.84)

1.00 (Reference)

3.14 (2.39–4.12)

0.065

Model 2 (HR and 95% CI)

1.00 (Reference)

2.34 (1.91–2.87)

1.00 (Reference)

1.92 (1.43–2.59)

1.00 (Reference)

2.78 (2.09–3.69)

0.062

Model 3 (HR and 95% CI)

1.00 (Reference)

1.96 (1.54–2.49)

1.00 (Reference)

1.52 (1.07–2.17)

1.00 (Reference)

2.40 (1.72–3.34)

0.081

Model 4 (HR and 95% CI)

1.00 (Reference)

1.98 (1.56–2.51)

1.00 (Reference)

1.54 (1.08–2.20)

1.00 (Reference)

2.48 (1.78–3.47)

0.076

Model 5 (HR and 95% CI)

1.00 (Reference)

1.88 (1.48–2.41)

1.00 (Reference)

1.50 (1.04–2.18)

1.00 (Reference)

2.39 (1.70–3.36)

0.042