Does hyperglycemia affect arginine metabolites in critically ill patients? A prospective cohort and in vitro study

Table 2 Simple and multiple linear regression analyses between measures of glycaemic control and arginine metabolites

	Glucose		HbA1c		SHR		Glucose*		HbA1c*		SHR*
	R	P value	r	P value	r	P value	β	P value	β	P value	Β	P value
ADMA (nmol/L)	0.012	0.671	0.002	0.940	0.016	0.590	0.004	0.879	− 0.046	0.109	0.038	0.190
Homoarginine (nmol/L)	0.057	0.054	0.086	0.004	0.123	< 0.001	0.067	0.018	− 0.048	0.097	0.107	< 0.001
Arginine (µmol/L)	0.004	0.897	0.009	0.755	0.001	0.994	0.005	0.860	0.025	0.405	− 0.009	0.762
MMA (nmol/L)	0.028	0.335	0.025	0.391	0.15	0.613	0.021	0.468	− 0.017	0.559	0.036	0.206
SDMA (nmol/L)	0.132	< 0.001	0.068	0.021	0.189	< 0.001	− 0.153	< 0.001	− 0.035	0.105	− 0.139	< 0.001

HbA1c glycosylated hemoglobin A1c; SHR stress hyperglycemia ratio; ADMA asymmetric dimethyl-l-arginine; MMA monomethyl-l-arginine; SDMA symmetric dimethyl-l-arginine
^*Corrected for log GFR. Log GFR is independently associated with arginine metabolite concentrations in all analyses

ISSN: 1758-5996