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Table 3 Associations of DM status and PNI level with clinical outcomes

From: Association of prognostic nutritional index level and diabetes status with the prognosis of coronary artery disease: a cohort study

Outcome

Events/Total

Event rate per 1000 pys

Crude HR (95% CI)

p

Adjusted HR (95% CI)

p

All-cause death

366/9429

7.87

–

–

–

–

 Non-DM/H-PNI

122/4217

5.83

Reference

–

Reference

–

 Non-DM/L-PNI

55/1256

8.89

1.53 (1.11, 2.10)

0.009

1.44 (1.05, 1.98)

0.026

 DM/H-PNI

113/3130

7.32

1.26 (0.97, 1.62)

0.080

1.16 (0.90, 1.51)

0.248

 DM/L-PNI

76/826

19.16

3.30 (2.47, 4.39)

 < 0.001

2.65 (1.97, 3.56)

 < 0.001

p for trend

–

–

 < 0.001

–

 < 0.001

–

 Cardiac death

219/9429

4.71

–

–

–

–

 Non-DM/H-PNI

69/4217

3.30

Reference

–

Reference

–

 Non-DM/L-PNI

35/1256

5.66

1.72 (1.14, 2.58)

0.009

1.61 (1.07, 2.43)

0.022

 DM/H-PNI

67/3130

4.34

1.32 (0.94, 1.84)

0.107

1.21 (0.86, 1.69)

0.274

 DM/L-PNI

48/826

12.10

3.68 (2.54, 5.31)

 < 0.001

2.83 (1.94, 4.14)

 < 0.001

p for trend

–

–

 < 0.001

–

 < 0.001

–

 Non-fatal MI

551/9429

12.18

–

–

–

–

 Non-DM/H-PNI

236/4217

11.58

Reference

–

Reference

–

 Non-DM/L-PNI

65/1256

10.75

0.93 (0.71, 1.22)

0.600

0.91 (0.69, 1.20)

0.495

 DM/H-PNI

199/3130

13.28

1.15 (0.95, 1.39)

0.152

1.08 (0.89, 1.31)

0.423

 DM/L-PNI

51/826

13.28

1.14 (0.84, 1.55)

0.386

1.03 (0.76, 1.40)

0.837

p for trend

–

–

0.1358

 

0.4946

 

 Non-fatal stroke

345/9429

7.54

–

–

–

–

 Non-DM/H-PNI

115/4217

5.57

Reference

–

Reference

–

 Non-DM/L-PNI

59/1256

9.74

1.75 (1.28, 2.39)

0.001

1.68 (1.22, 2.30)

0.001

 DM/H-PNI

131/3130

8.66

1.56 (1.21, 2.00)

0.001

1.46 (1.14, 1.88)

0.003

 DM/L-PNI

40/826

10.32

1.85 (1.29, 2.66)

0.001

1.63 (1.13, 2.35)

0.009

p for trend

–

–

 < 0.001

–

0.001

–

 Unplanned revascularization

1371/9429

32.46

–

–

–

–

 Non-DM/H-PNI

577/4217

30.21

Reference

–

Reference

–

 Non-DM/L-PNI

154/1256

26.98

0.89 (0.75, 1.07)

0.217

0.89 (0.75, 1.07)

0.220

 DM/H-PNI

519/3130

37.50

1.23 (1.10, 1.39)

0.001

1.21 (1.07, 1.36)

0.002

 DM/L-PNI

121/826

33.81

1.11 (0.91, 1.35)

0.308

1.07 (0.88, 1.31)

0.475

p for trend

–

–

0.003

–

0.011

–

 MACCE

2143/9429

52.36

–

–

–

–

 Non-DM/H-PNI

851/4217

45.71

Reference

–

Reference

–

 Non-DM/L-PNI

269/1256

48.66

1.06 (0.93, 1.22)

0.375

1.04 (0.91, 1.20)

0.543

 DM/H-PNI

777/3130

58.17

1.26 (1.55, 1.39)

 < 0.001

1.21 (1.10, 1.34)

 < 0.001

 DM/L-PNI

246/826

71.86

1.55 (1.35, 1.79)

 < 0.001

1.42 (1.23, 1.65)

 < 0.001

p for trend

–

–

 < 0.001

–

 < 0.001

–

  1. Preprocedural PNI was categorized by the optimal cut-off value for all-cause death of 48.49. Adjusted for sex, age, hypertension, chronic obstructive pulmonary disease, previous revascularization, previous myocardial infarction, previous stroke, high-sensitivity C-reactive protein, estimated glomerular filtration rate, and left ventricular ejection fraction
  2. CI confidence interval, DM diabetes, H high, HR hazard ratio, L low, PNI prognostic nutritional index, pys person years, MACCE major adverse cardiovascular and cerebrovascular events, MI myocardial infarction
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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