Table 3 Threshold effect analysis of S100A11 on metabolic markers by using two-piecewise linear regression, stratified by glucose tolerance
From: Association between serum S100A11 levels and glucose metabolism in diabetic process
Inflection points of HbA1c | Inflection points of FPG | Inflection points of 0.5hPPG | Inflection points of FPI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | (95%CI) | P | β | (95%CI) | P | β | (95%CI) | P | β | (95%CI) | P | |
Normal | > 5.78 | 0.26 (0.04, 0.47) | 0.0316 | > 4.19 | 0.16 (− 0.01, 0.32) | 0.0741 | > 4.19 | − 0.51 (− 0.98, − 0.03) | 0.0482 | > 2.76 | 2.43 (− 4.47, 9.33) | 0.4965 |
≤ 5.78 | − 0.43 (− 0.85, − 0.02) | 0.0538 | ≤ 4.19 | − 0.06 (− 0.20, 0.08) | 0.4184 | ≤ 4.19 | 0.15 (− 0.26, 0.55) | 0.4804 | ≤ 2.76 | − 0.71 (− 2.69, 1.27) | 0.4906 | |
IGT | > 8.74 | − 0.11 (− 0.22, 0.01) | 0.1010 | > 8.29 | 0.06 (− 0.08, 0.21) | 0.3874 | > 3.63 | − 10.72 (− 23.94, 2.50) | 0.1329 | > 6.48 | 4.07 (0.56, 7.58) | 0.0383 |
≤ 8.74 | 3.41 (− 0.03, 6.85) | 0.0708 | ≤ 8.29 | 0.06 (− 0.08, 0.21) | 0.3874 | ≤ 3.63 | 0.40 (− 0.05, 0.85) | 0.1028 | ≤ 6.48 | − 4.29 (− 8.85, 0.28) | 0.0856 | |
Diabetes | > 12.4 | 0.11 (− 0.05, 0.28) | 0.1979 | > 12.4 | − 0.09 (− 0.26, 0.08) | 0.3082 | > 3.97 | 2.36 (− 1.82, 6.55) | 0.2783 | > 4.1 | 8.67 (1.79, 15.56) | 0.0201 |
≤ 12.4 | − 0.90 (− 1.63, − 0.18) | 0.0213 | ≤ 12.4 | 0.88 (0.15, 1.62) | 0.0262 | ≤ 3.97 | − 0.10 (− 0.39, 0.20) | 0.5325 | ≤ 4.1 | − 0.36 (− 0.97, 0.25) | 0.2588 | |
Inflection points of HOMA-IR | Inflection points of ISI (the liver) | Inflection points of ISI (the body) | Inflection points of CIR | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | (95%CI) | P | β | (95%CI) | P | β | (95%CI) | P | β | (95%CI) | P | |
Normal | > 2.76 | 0.88 (− 0.66, 2.42) | 0.2750 | > 4.19 | − 1.06 (− 4.13, 2.01) | 0.5061 | > 5.08 | − 0.30 (− 0.81, 0.20) | 0.2520 | > 7.44 | 33.88 (− 0.75, 68.51) | 0.0677 |
≤ 2.76 | − 0.21 (− 0.68, 0.25) | 0.3770 | ≤ 4.19 | 1.22 (− 1.35, 3.78) | 0.3623 | ≤ 5.08 | 0.14 (− 0.55, 0.82) | 0.7013 | ≤ 7.44 | − 118.09 (− 369.04, 132.86) | 0.3659 | |
IGT | > 6.48 | 1.31 (0.28, 2.33) | 0.0235 | > 5.49 | 2.57 (− 1.73, 6.87) | 0.2591 | > 3.63 | − 12.94 (− 24.64, − 1.25) | 0.0437 | > 5.49 | − 58.38 (− 97.32, − 19.44) | 0.0096 |
≤ 6.48 | − 1.32 (− 2.67, 0.02) | 0.0718 | ≤ 5.49 | − 2.84 (− 5.52, − 0.17) | 0.0532 | ≤ 3.63 | 0.05 (− 0.37, 0.47) | 0.8173 | ≤ 5.49 | 5.74 (− 18.22, 29.71) | 0.6448 | |
Diabetes | > 9.71 | − 0.17 (− 0.63, 0.29) 0.4725 | > 3.33 | − 20.05 (− 38.24, − 1.86) | 0.0395 | > 5.24 | 1.80 (− 0.86, 4.45) | 0.1945 | > 4.1 | − 22.54 (− 57.37, 12.29) | 0.2152 | |
≤ 9.71 | 1.03 (0.15, 1.91) | 0.0300 | ≤ 3.33 | 0.10 (− 0.30, 0.51) | 0.6208 | ≤ 5.24 | − 0.88 (− 1.62, − 0.15) | 0.0256 | ≤ 4.1 | 1.36 (− 1.63, 4.35) | 0.3809 | |