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Table 7 The multivariate logistic regression analysis of risk factors of diabetic foot osteomyelitis

From: Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers

Variable

β

SE

Wald

OR

95% CI

P value

Duration of ulcers (w)

0.69

0.35

9.22

4.81

1.21 ~ 11.63

 < 0.001

Severity of infection

0.52

0.29

5.83

2.07

1.09 ~ 10.34

0.012

HbA1c (%)

0.41

0.23

6.03

2.35

1.24 ~ 9.26

0.009

ABI

0.38

0.19

3.59

1.46

1.12 ~ 7.49

0.027

WBC (× 109)

0.21

0.11

2.87

1.19

1.04 ~ 6.18

0.041

ESR (mm/h)

0.46

0.25

4.96

1.87

1.13 ~ 9.15

0.018

25 (OH) VD (ng/ml)

0.58

0.26

7.15

3.05

1.07 ~ 12.53

0.001

T-VDR

0.49

0.17

5.12

2.83

1.15 ~ 9.97

0.004

  1. Multivariate unconditional logistic regression analysis adjusted for for sex, age, duration of diabetes, duration of ulcers, frequent smoking, long term drinking, mean sunshine time per day, Wagner grade, severity of infection, detection rate of drug resistant bacteria, SBP, DBP, FPG, HbA1c, TG, TCH, LDL-C, HDL-C, eGFR, ALB, Hb, TcPO2, ABI, CRP, WBC, ESR, P-IL-6, P-IL-10, serum 25 (OH)VD
  2. SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c glycated hemoglobin A1c, TG triacylglycerol, TCH total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, eGFR Estimated glomerular filtration rate, ALB serum albumin, Hb hemoglobin, TcPO2 transcutaneous oxygen pressure, ABI ankle brachial index, CRP C-reactive protein, WBC white blood cell, ESR erythrocyte sedimentation rate, P-IL-6 IL-6 level in peripheral blood, P-IL-10 IL-10 level in peripheral blood, 25(OH)VD 25-hydroxyvitamin D, T-VDR vitamin D receptor mRNA expression in wound margin tissue