| High expression group (n = 32) | Low expression group (n = 52) | P value |
---|---|---|---|
Age (y) | 55.6 ± 10.5 | 56.4 ± 11.1 | 0.482 |
Sex | Â | Â | 0.830 |
 Male | 18 (56.3) | 28 (53.8) |  |
 Female | 14 (43.7) | 24 (46.2) |  |
Ulcer area (cm2) | Â | Â | 0.786 |
 ≤ 5 | 3 (9.4) | 7 (13.5) |  |
 5 ~ 10 | 18 (56.3) | 30 (57.7) |  |
 > 10 | 11 (34.3) | 15 (28.8) |  |
Ulcer duration (week) | Â | Â | 0.037 |
 ≤ 6 | 4 (12.5) | 5 (9.6) |  |
 6 ~ 10 | 18 (56.3) | 16 (30.8) |  |
 > 10 | 10 (31.2) | 31 (59.6) |  |
Wagner grade | Â | Â | 0.011 |
 II | 0 (0.0) | 0 (0.0) |  |
 III | 25 (75.0) | 25 (46.1) |  |
 IV | 7 (18.7) | 27 (48.1) |  |
Severity of infection | Â | Â | 0.041 |
 Mild | 0 (0.0) | 0 (0.0) |  |
 Moderate | 24 (75.0) | 27 (51.9) |  |
 Severe | 8 (25.0) | 25 (48.1) |  |
Recurrent DFU | 8 (25.0) | 26 (50.0) | 0.023 |
Detection rate of drug resistant bacteria | 7 (21.9) | 27 (51.9) | 0.006 |
Outcome of ulcer after 8Â weeks | Â | Â | 0.021 |
 Healing | 20 (62.5) | 19 (36.5) |  |
 Non-healing | 12 (37.5) | 33 (63.5) |  |
Amputation rate (%) | Â | Â | 0.039 |
 Amputation | 5 (15.6) | 19 (36.5) |  |
 Non-amputation | 27 (84.4) | 33 (63.5) |  |