| High expression group (n = 53) | Low expression group (n = 103) | P value |
---|---|---|---|
Age (y) | 55.1 ± 10.8 | 55.8 ± 11.3 | 0.613 |
Sex | Â | Â | 0.162 |
 Male | 34 (64.2) | 54 (52.4) |  |
 Female | 19 (35.8) | 49 (47.6) |  |
Ulcer area (cm2) | Â | Â | 0.787 |
 ≤ 5 | 7 (13.2) | 17 (16.5) |  |
 5 ~ 10 | 30 (56.6) | 57 (55.4) |  |
 > 10 | 16 (30.2) | 29 (28.1) |  |
Ulcer duration (week) | Â | Â | 0.014 |
 ≤ 6 | 9 (17.0) | 12 (11.7) |  |
 6 ~ 10 | 32 (60.4) | 43 (41.7) |  |
 > 10 | 12 (22.6) | 48 (46.6) |  |
Wagner grade | Â | Â | 0.030 |
 II | 12 (22.6) | 8 (7.7) |  |
 III | 32 (60.3) | 76 (73.9) |  |
 IV | 9 (7.1) | 19 (18.4) |  |
Severity of infection | Â | Â | 0.021 |
 Mild | 12 (22.6) | 8 (7.8) |  |
 Moderate | 26 (49.1) | 68 (66.0) |  |
 Severe | 15 (28.3) | 27 (26.2) |  |
Recurrent DFU | 11 (20.8) | 40 (38.8) | 0.023 |
Detection rate of drug resistant bacteria | 10 (18.9) | 41 (39.8) | 0.012 |
Outcome of ulcer after 8Â weeks | Â | Â | 0.016 |
 Healing | 35 (66.0) | 47 (45.6) |  |
 Non-healing | 18 (34.0) | 56 (54.4) |  |
Amputation rate (%) | Â | Â | 0.040 |
 Amputation | 8 (15.1) | 31 (30.1) |  |
 Non-amputation | 45 (84.9) | 72 (69.9) |  |