Variable | NDFO group (n = 72) | DFO group (n = 84) | P value |
---|---|---|---|
Sex (male/female) | 72(42/30) | 84(46/38) | 0.654 |
Age (year) | 55.2 ± 11.6 | 55.8 ± 10.9 | 0.451 |
Duration of diabetes (year) | 10.8 ± 5.7 | 13.9 ± 6.8 | 0.014 |
Duration of ulcers (week) | 5.1 (4.0, 9.3) | 6.8 (4.8, 16.2) | 0.003 |
Area of DFU (cm2) | 11.5 ± 4.3 | 10.7 ± 3.9 | 0.271 |
Smoking habits | 38 (52.8) | 42 (50.0) | 0.729 |
Alcohol consumption | 23 (31.9) | 20 (23.8) | 0.854 |
Mean sunshine time per day (h) | 3.2 (1.2, 5.8) | 2.1 (1.1, 4.9) | 0.025 |
Winter enrollment | 30 (41.7) | 39 (46.4) | 0.551 |
Wagner grade |  |  |  < 0.001 |
 II | 20 (27.8) | 0 (0.00) |  |
 III | 47 (65.3) | 61 (72.6) |  |
 IV | 5 (6.9) | 23 (27.4) |  |
Severity of infection |  |  |  < 0.001 |
 Mild | 20 (27.8) | 0 (0.00) |  |
 Moderate | 40 (55.6) | 54 (64.3) |  |
 Severe | 12 (6.6) | 30 (35.7) |  |
Recurrent DFU | 17 (23.6) | 34 (40.5) | 0.033 |
Detection rate of drug -resistant bacteria | 17 (23.6) | 34 (40.5) | 0.025 |
SBP (mm Hg) | 121 ± 13 | 125 ± 15 | 0.487 |
DBP (mm Hg) | 81 ± 14 | 83 ± 15 | 0.679 |
FPG (mmol/L) | 11.2 ± 2.5 | 12.8 ± 2.8 | 0.032 |
HbA1c(%) | 8.7 ± 1.5 | 9.5 ± 1.8 | 0.024 |
TG (mmol/L) | 1.8 ± 0.8 | 2.4 ± 0.9 | 0.103 |
TCH (mmol/L) | 4.7 ± 0.8 | 4.5 ± 0.7 | 0.594 |
LDL-C (mmol/L) | 2.7 ± 0.5 | 2.9 ± 0.6 | 0.626 |
HDL-C (mmol/L) | 1.0 ± 0.2 | 0.9 ± 0.3 | 0.753 |
PTH (pg/mL) | 16.4 (9.7, 28.6) | 18.1 (10.9, 39.2) | 0.102 |
Serum ionic calcium (mmol/L) | 0.85 ± 0.15 | 0.87 ± 0.17 | 0.285 |
eGFR (ml/min/1.73m2) | 83.7 ± 11.9 | 71.5 ± 12.6 | 0.042 |
ALB (g/L) | 40.7 ± 8.9 | 35.7 ± 6.5 | 0.038 |
Hb (g /L) | 122.8 ± 9.3 | 104.8 ± 8.6 | 0.046 |
TcPO2 (mm Hg) | 52.8 ± 8.5 | 39.1 ± 10.1 | 0.013 |
ABI | 0.82 ± 0.21 | 0.65 ± 0.14 | 0.026 |
CRP ( mg/dL) | 31.7 ± 13.7 | 62.2 ± 18.5 |  < 0.001 |
WBC (× 109) | 10.2 ± 3.6 | 12.9 ± 3.8 | 0.002 |
ESR (mm/h) | 36.7 ± 12.8 | 67.9 ± 17.2 |  < 0.001 |
25(OH)VD (ng/mL) | 12.8 (6.9, 22.1) | 9.2 (5.2, 20.5) | 0.006 |
VitD status | Â | Â | 0.007 |
 Deficiency | 43 (59.7) | 69 (82.1) |  |
 Insufficiency | 23 (31.9) | 13 (15.5) |  |
 Sufficiency | 6 (8.4) | 2 (2.4) |  |
P-IL-6 (pg/ml) | 39.2 ± 12.8 | 51.7 ± 14.5 | 0.009 |
P-IL-10 (ng/L) | 4.7 ± 1.6 | 3.1 ± 1.2 | 0.036 |
T-IL-6 | 2.93 (1.54, 4.82) | 3.82 (2.07, 6.23) | 0.013 |
T-IL-10 | 0.72 (0.31, 1.32) | 0.48 (0.12, 0.95) | 0.036 |
T-VDR | 3.11 (1.36, 5.11) | 1.96 (0.61–3.97) | 0.004 |