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Table 3 Univariate and multivariate regression analyses for changes in UPCR and UACR

From: Effect of olmesartan and amlodipine on serum angiotensin-(1–7) levels and kidney and vascular function in patients with type 2 diabetes and hypertension

Univariate

Multivariate

Variable

Coefficient

P

Standardized coefficient

P

∆ log UPCR

    

 Age

0.004

0.478

–

–

 ∆ Systolic BP

 − 0.007

0.129

–

–

 ∆ Diastolic BP

 − 0.003

0.525

–

–

 ∆ Fasting glucose

 − 0.003

0.021

–

–

 ∆ HbA1c

 − 0.092

0.232

–

–

 ∆ log HOMA-IR

0.333

0.005

0.258

0.010

 ∆ eGFR

0.003

0.427

–

–

 ∆ log hsCRP

0.112

0.199

–

–

 ∆ log Ang-(1–7)

 − 0.229

0.001

 − 0.350

0.001

 ∆ ACE2

0.000

0.320

–

–

 ∆ log PRA

 − 0.042

0.480

–

–

 ∆ Aldosterone

0.033

 < 0.001

0.406

 < 0.001

   

Model R2 = 0.400

∆ log UACR

   

 Age

0.001

0.988

–

–

 ∆ Systolic BP

 − 0.019

0.004

–

–

 ∆ Diastolic BP

 − 0.023

0.005

–

–

 ∆ Fasting glucose

 − 0.006

0.004

 − 0.248

0.015

 ∆ HbA1c

 − 0.232

0.045

–

–

 ∆ log HOMA-IR

0.357

0.053

–

–

 ∆ eGFR

 − 0.001

0.911

–

–

 ∆ log hsCRP

0.158

0.223

–

–

 ∆ log Ang-(1–7)

 − 0.265

0.011

 − 0.202

0.040

 ∆ ACE2

 − 0.001

0.034

–

–

 ∆ log PRA

 − 0.152

0.090

 − 0.265

0.008

 ∆ Aldosterone

0.052

 < 0.001

0.452

 < 0.001

   

Model R2 = 0.426

  1. UPCR urinary protein-to-creatinine ratio, UACR urinary albumin-to-creatinine ratio, HOMA-IR homeostasis model assessment of insulin resistance; eGFR estimated glomerular filtration rate, hsCRP high-sensitivity C-reactive protein, ACE2 angiotensin-converting enzyme-2, PRA plasma renin activity; R2 multiple coefficient of determination, ∆ change (the value at week 24 minus the value at baseline)
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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