Table 1 Different cut-off points of the maturity-onset diabetes of the young (MODY) calculator, comparing MODY with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with their respective specificity and sensitivity
Model | Cut-off for a probability of classification of MODY based on the logistic regression model (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
10% | 20% | 30% | 40% | 50% | 60% | 70% | 80% | 90% | |
T1DM and T2DM versus MODY | |||||||||
Sensitivity (%) | 98.51 | 98.15 | 98.17 | 97.85 | 96.14 | 96.15 | 94.5 | 70.84 | |
Specificity (%) | 89.43 | 90.83 | 92.37 | 96.43 | 97.17 | 98.1 | 98 | ||
LR + for MODY (95%CI) | 9.3203 (5.5729–15.5876) | 10.7078 (6.0953–18.8107) | 12.871 (6.8679–24.1213) | 27.3979 (10.4645–71.7326) | 33.9696 (11.1314–103.6652) | 50.4808 (12.7912–199.2239) | 47.2509 (11.9797–186.3684) | – | |
PPV for MODY | 78.27% | 80.54% | 83.26% | 91.37% | 92.92% | 95.12% | 94.81% | – | |
LR− for MODY (95%CI) | 0.0167 (0.0063 –0.0442) | 0.0203 (0.0085–0.0485) | 0.0198 (0.0083–0.0473) | 0.0223 (0.0101–0.0493) | 0.0397 (0.0222–0.0710) | 0.0392 (0.0220–0.0700) | 0.0561 (0.0348–0.0904) | – | |
NPV for MODY | 99.36% | 99.22% | 99.24% | 99.15% | 98.49% | 98.51% | 97.88% | ||
Accuracy | 91.96% | 92.87% | 93.99% | 96.82% | 96.88% | 97.55% | 97.02% | ||