Non-altered incretin secretion in women with impaired fasting plasma glucose in the early stage of pregnancy: a case control study

Table 2 Area under the curve during 3 h mixed meal tolerance test for glucose and hormones levels in individual groups

	Pregnant women i-FPG (n = 22)	Healthy pregnant women (n = 25)	Non-pregnant healthy controls (n = 24)	corrected p-value
glucose_AUC (mmol/mL/min)	5.47 ± 1.00^b,c	4.40 ± 0.64^a	4.40 ± 0.53^a	< 0.001
glucose_AUC adjusted for BMI (mmol/mL/min)	5.05 ± 0.88	4.54 ± 0.73	4.62 ± 0.48	NS
C-peptide_AUC (pg/mL/min)	3037 (833)^b,c	2307 (822)^a	2092 (554)^a	< 0.001
C-peptide_AUC adjusted for BMI (pg/mL/min)	2716 (954)	2477 (941)	2235 (760)	NS
insulin_AUC (pg/mL/min)	1979 (973)^b,c	1271 (734)^a	1001 (692)^a	0.007
insulin_AUC adjusted for BMI (pg/mL/min)	1751 (660)	1485 (940)	1079 (723)	NS
GLP-1_AUC (pg/mL/min)	19.0 (53.1)	16.7 (22.3)	16.7 (9.8)	NS
GLP-1_AUC adjusted for BMI (pg/mL/min)	19.6 (54.9)	16.9 (18.5)	17.0 (10.6)	NS
GIP_AUC (pg/mL/min)	317 ± 124	290 ± 89	303 ± 80	NS
GIP_AUC adjusted for BMI (pg/mL/min)	336 ± 119	286 ± 85	297 ± 81	NS
glucagon_AUC (pg/mL/min)	63.2 ± 28.1	61.7 ± 32.9	60.6 ± 29.5	NS
glucagon_AUC adjusted for BMI (pg/mL/min)	65.8 ± 26.9	61.6 ± 32.9	60.3 ± 29.4	NS

Values are expressed means ± standard deviation or medians and interquartile ranges (for data with non-normal distribution). Difference between groups was tested by one-way ANOVA for normally distributed variables or Kruskal–Wallis test otherwise. Holm-Bonferroni procedure was used to correct for multiple testing. In cases of significant difference pairwise tests were performed by t-test for normally distributed variables or to the Mann–Whitney U-test otherwise:
i-FP impaired fasting plasma glucose, GLP-1 = glucagon-like peptide 1, GIP glucose-dependent insulinotropic peptide, AUC area under the curve during 3 h mixed meal tolerance test, NS non-significant
^a = vs pregnant women with i-FPG
^b = vs healthy pregnant women
^c = vs non-pregnant healthy controls

ISSN: 1758-5996