Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus

Table 3 Summary of studies evaluated important SNPs in GDM

Genes	Function	Variant	Detection method	Sample size (case/control)	Association	Risk for GDM	References
ADIPOQ	β-cell function	rs1501299	Realtime-PCR	204/207	No association	–	[89]
		rs266729	Realtime-PCR	204/207	G allele	Increased	[89]
		rs2241766	RFLP-PCR	65/70	G allele	Increased	[90]
GCK	β-cell function	rs1799884	Realtime-PCR	204/207	No association	–	[69]
		rs1799884	Realtime-PCR	278/179	T allele	Increased	[91]
		rs4607517	MassARRAY	533/407	No association	–	[92]
GCKR	β-cell function	rs780094	MassARRAY	267/855	C allele	Increased	[70]
GCKR	β-cell function	rs780094	Realtime-PCR	204/207	No association	–	[69]
IRS-1	Insulin action	rs1801278	Realtime-PCR	278/179	No association	–	[91]
		rs1801278	RFLP	200/300	T allele	Increased	[93]
		rs7578326	MassARRAY	533/407	No association	–	[92]
		rs7578326	KASP	287/533	G allele	Decreased	[94]
IGF2BP2	β-cell function	rs4402960	Realtime-PCR	278/179	No association	–	[91]
IGF2BP2	β-cell function	rs4402960	Realtime-PCR	725/1039	T allele	Increased	[95]
PPARG2	Insulin action	rs1801282	HRM	104/124	No association	–	[96]

ADIPOQ adiponectin, GCK glucokinase, GCKR glucokinase Regulator, IGF2BP2 insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2, IRS1 insulin receptor substrate 1, PPARG2 peroxisome proliferator-activated receptor gamma 2

ISSN: 1758-5996