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Table 1 Main characteristics according to intrinsic capacity score

From: Interactive effects of intrinsic capacity and obesity on the KDIGO chronic kidney disease risk classification in older patients with type 2 diabetes mellitus

 

Total

IC score 0

IC score 1

IC score ≥ 2

p-value

Number

2482

1525

655

302

 

Age (years)

72.4 ± 5.8

71.2 ± 5.0

73.2 ± 5.9

77.0 ± 6.6

 < 0.0001

Sex, female (n, %)

1374(55.4)

790(51.8)

393(60.0)

191(63.3)

 < 0.0001

Diabetes duration (years)

13.5 ± 9.0

13.1 ± 8.8

13.7 ± 9.2

15.2 ± 9.2

0.001

Hypertension (n, %)

1552(62.5)

917(60.1)

438(66.9)

197(65.2)

0.007

Hyperlipidemia (n, %)

1956(78.8)

1217(79.8)

503(76.8)

236(78.2)

0.276

Current smoker (n, %)

486(19.6)

315(20.7)

121(18.5)

50(16.6)

0.184

Body mass index (kg/m2)

25.6 ± 4.0

25.4 ± 3.8

26.0 ± 4.2

25.8 ± 4.2

0.001

Waist-to-hip ratio

0.93 ± 0.07

0.92 ± 0.07

0.93 ± 0.07

0.93 ± 0.07

0.156

SBP (mmHg)

129 ± 16

128 ± 15

130 ± 16

130 ± 19

0.076

DBP (mmHg)

73 ± 11

73 ± 11

73 ± 11

73 ± 11

0.669

Obesity status (n, %)

 Underweight

35(1.4)

19(1.3)

11(1.7)

5(1.7)

0.681

 Normal weight

886(35.7)

571(37.4)

210(32.1)

105(34.8)

0.052

 Overweight

782(31.5)

485(31.8)

199(30.4)

98(32.5)

0.752

 Mild obesity

451(18.2)

278(18.2)

129(19.7)

44(14.6)

0.160

 Moderate obesity

274(11.0)

147(9.6)

88(13.4)

39(12.9)

0.019

 Severe obesity

54(2.2)

25(1.6)

18(2.8)

11(3.6)

0.047

KDIGO CKD risk stage (n, %)

 Low risk

1167(47.0)

789(51.7)

289(44.1)

89(29.5)

 < 0.0001

 Moderately increased risk

610(24.6)

379(24.9)

154(23.5)

77(25.5)

0.740

 High risk

368(14.8)

192(12.6)

108(16.5)

68(22.5)

 < 0.0001

 Very high risk

337(13.6)

165(10.8)

104(15.9)

68(22.5)

 < 0.0001

Type of treatment (%)

 (OHA/Insulin/Both)

67.8/3.2/29.1

71.6/2.1/26.3

65.5/4.6/30.0

53.7/5.3/41.0

 < 0.0001

 Statins (n, %)

1919(77.3)

1193(78.2)

494(75.4)

232(76.8)

0.348

 ARB (n, %)

1085(43.7)

626(41.1)

317(48.4)

142(47.0)

0.003

Biochemical characteristics

 HbA1c (%)

7.3 ± 1.2

7.2 ± 1.1

7.2 ± 1.2

7.5 ± 1.4

0.006

 Fasting glucose (mmol/L)

8.5 ± 3.4

8.4 ± 3.3

8.5 ± 3.4

8.9 ± 3.8

0.001

 Total cholesterol (mmol/L)

4.1 ± 0.8

4.1 ± 0.8

4.1 ± 0.8

4.0 ± 0.8

0.671

 Triglycerides (mmol/L)

1.3 ± 0.7

1.3 ± 0.8

1.3 ± 0.7

1.3 ± 0.6

0.694

 HDL cholesterol (mmol/L)

1.4 ± 0.4

1.4 ± 0.4

1.4 ± 0.4

1.4 ± 0.4

0.986

 LDL cholesterol (mmol/L)

2.1 ± 0.6

2.1 ± 0.6

2.1 ± 0.7

2.1 ± 0.6

0.503

 Uric acid (mmol/L)

5.4 ± 1.6

0.3 ± 0.1

0.3 ± 0.1

0.3 ± 0.1

0.841

 eGFR (ml/min/1.73m2)

68.9 ± 22.0

77.2 ± 20.5

73.3 ± 21.5

71.0 ± 23.0

 < 0.0001

 UACR (mg/g)

19.2(9.7–54.3)

17.1(8.8–46.5)

21.0(10.9–60.9)

29.3(13.4–83.6)

 < 0.0001

 Creatinine (µmol/L)

97.2 ± 53.0

94.6 ± 48.6

102.5 ± 67.2

107.9 ± 56.6

 < 0.0001

 Hemoglobin (g/L)

136 ± 17

138 ± 17

133 ± 17

131 ± 17

 < 0.0001

  1. Data are presented as mean ± SD, number (percentage), or median (interquartile range)
  2. IC intrinsic capacity, SBP systolic blood pressure, DBP diastolic blood pressure, CKD chronic kidney disease, OHA oral hypoglycemic agents, ARB angiotensin receptor blocker, HDL high-density lipoprotein, LDL low-density lipoprotein, eGFR estimated glomerular filtration rate, UACR urinary albumin-to-creatinine ratio