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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly

Fig. 3

High-glucose-inhibited MFLEC angiogenesis through mTOR pathway in vitro. The MFLECs were pre-incubated in a culture medium containing 5 mM glucose (control) or 30 mM glucose (high glucose) or 30 mM glucose with 100ng/ml rapamycin (HG + RAPA) for 72 h and loaded into Matrigel. The cells treated with high glucose levels exhibited a dramatic decrease in the total number of branch points while the number was almost restored to control level in HG + RAPA group. (HG: high glucose, RAPA: rapamycin, n = 3 in triplicate, ***p < 0.001, * p < 0.05)

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