Table 3 The comparisons of intestinal barrier biomarkers, HbA1c, FBG, indicators of clinical characteristics, disease severity, and prognosis between survivors and non-survivors
Survivors | Non-survivors | P value | ||
|---|---|---|---|---|
Demographics | ||||
Sex (male/female) | 51/39 | 15/4 | 0.119 | |
Age, y | 63.5 (44.75, 76.25) | 66 (55, 79) | 0.531 | |
HbA1c, % | 5.75 (5.2, 6.83) | 6.1 (5.4, 7) | 0.522 | |
FBG, mmol/L | 7.88 (6.11, 10.40) | 7.35 (5.95, 8.55) | 0.554 | |
Intestinal barrier biomarkers | ||||
DAO, U/L | 24.1 (10.50, 33.8) | 28.51 (8.54, 37.34) | 0.905 | |
D-lactate, mg/L | 33.79 (18.48, 49.95) | 47.54 (27.52, 60.58) | 0.038* | |
LPS, U/L | 9.36 (6.19, 15.27) | 17.73 (7.96, 26.49) | 0.027* | |
Infection and immunity | ||||
WBC, 10^9/L | 14.51 ± 7.03 | 18.12 ± 10.10 | 0.178 | |
NEU proportion, % | 91 (88.2, 94) | 92.2 (83.6, 93.7) | 0.806 | |
CRP, mg/L | 65.95 (17.38, 166.8) | 96.9 (10.3, 197.1) | 0.669 | |
Procalcitonin, µg/L | 1.76 (0.47, 8.37) | 4.16 (1.87, 24.17) | 0.045* | |
HLA-DR, % | 46.1 (34.25, 66.68) | 30.65 (26.25, 57.83) | 0.076 | |
Temperature, ℃ | 38.2 (37.5, 38.8) | 38.0 (37.0, 38.7) | 0.316 | |
Respiratory and circulatory system | ||||
Oxygenation index | 258 (197, 340) | 268 (194, 343) | 0.618 | |
Respiratory rate, RPM | 23 (20, 25) | 23 (16, 25) | 0.418 | |
Heart rate, RPM | 107.5 (86.25, 122) | 108 (92, 130) | 0.352 | |
MAP, mmHg | 67 (60.9, 79) | 65 (59.3, 101.3) | 0.917 | |
Artery blood pH | 7.37 (7.27, 7.41) | 7.33 (7.23, 7.42) | 0.417 | |
Lactate, mmol/L | 3.0 (1.6, 4.9) | 4.1 (2.9, 9.2) | 0.019* | |
Dosage of NE, ug/kg/min | 0.10 (0, 0.30) | 0.60 (0.10, 1.27) | 0.004** | |
Renal function | ||||
Urea nitrogen, mmol/L | 7.85 (4.98, 10.63) | 10.4 (6.6, 18.8) | 0.017* | |
Creatinine, µmol/L | 102.2 (70.78, 151.6) | 150.9 (89.7, 271.8) | 0.039* | |
AKI morbidity (N) | 31.1% (28) | 57.9% (11) | 0.027* | |
Liver function | ||||
ALT, U/L | 39 (19, 72) | 32 (17, 328) | 0.528 | |
AST, U/L | 43.5 (27, 83) | 59 (30, 220) | 0.096 | |
Total bilirubin, µmol/L | 18.3 (12.63, 29.85) | 24.7 (14.6, 39.3) | 0.128 | |
Direct bilirubin, µmol/L | 9.75 (6.05, 16.85) | 13.3 (7.0, 25.3) | 0.174 | |
Total protein, g/L | 52.42 ± 12.69 | 46.64 ± 13.54 | 0.084 | |
Albumin, g/L | 28.61 ± 7.68 | 25.13 ± 8.52 | 0.090 | |
Prealbumin, mg/L | 156.97 ± 81.69 | 109.86 ± 76.73 | 0.017* | |
Disease severity and prognosis | ||||
APACHE II | 15 (10, 19.25) | 20 (17, 24) | < 0.001** | |
SOFA | 7 (5, 9) | 9 (9, 12) | 0.001** | |
LOS in hospital, day | 25.5 (13, 41.5) | 13 (3, 26) | 0.002** | |
LOS in ICU, day | 7 (3, 15.8) | 3 (2, 6) | 0.015* | |