Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia?

Wang, Yi-Feng; Liang, Feng-Ming; Liu, Min; Ding, Li-Cheng; Hui, Jiao-Jie; Xu, Hong-Yang; Liu, Li-Jun

doi:10.1186/s13098-022-00943-5

Table 2 Correlation analyses between intestinal barrier biomarkers, HbA1c, FGB, indicators of clinical characteristics, disease severity, and prognosis

From: Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia?

	DAO		D-lactate		LPS
	r value	P value	r value	P value	r value	P value
Intestinal barrier biomarkers
DAO	–	–	0.223	0.020*	0.279	0.003**
D-lactate	0.223	0.020*	–	–	0.305	0.001**
LPS	0.279	0.003**	0.305	0.001**	–	–
Demographics
Sex	–	0.484	–	0.938	–	0.209
Age	− 0.083	0.394	− 0.087	0.366	0.032	0.740
HbA1c	− 0.436	< 0.001**	− 0.087	0.370	− 0.038	0.695
FBG	0.092	0.341	− 0.086	0.376	0.099	0.307
Infection and immunity
WBC	− 0.045	0.640	0.036	0.707	− 0.075	0.440
NEU proportion	0.096	0.325	− 0.046	0.637	0.005	0.962
CRP	− 0.090	0.353	− 0.076	0.434	0.031	0.750
Procalcitonin	0.064	0.511	0.366	< 0.001**	0.106	0.271
HLA-DR	− 0.219	0.027*	− 0.182	0.067	− 0.109	0.274
Temperature	0.062	0.522	0.084	0.385	0.133	0.169
Respiratory and circulatory system
Oxygenation index	0.013	0.890	0.002	0.983	− 0.108	0.264
Respiratory rate	0.092	0.343	0.216	0.024*	0.221	0.021*
Heart rate	0.043	0.660	0.451	< 0.001**	0.181	0.060
MAP	0.086	0.376	− 0.248	0.009**	0.044	0.646
Artery blood pH	0.150	0.120	− 0.202	0.035*	0.030	0.759
Lactate	0.139	0.152	0.418	< 0.001**	0.019	0.844
Dosage of NE	0.061	0.529	0.356	< 0.001**	0.058	0.548
Renal function
Urea nitrogen	− 0.004	0.965	0.247	0.010**	0.143	0.137
Creatinine	0.040	0.679	0.287	0.003**	0.121	0.211
AKI morbidity	–	0.226	–	0.016*	–	0.069
Liver function
ALT	0.257	0.007**	0.502	< 0.001**	0.257	0.007**
AST	0.157	0.103	0.531	< 0.001**	0.266	0.005**
Total bilirubin	0.125	0.195	0.204	0.034*	0.293	0.002**
Direct bilirubin	0.135	0.161	0.259	0.007**	0.398	< 0.001**
Total protein	0.013	0.893	− 0.237	0.013*	− 0.047	0.626
Albumin	− 0.008	0.936	− 0.242	0.011*	− 0.109	0.260
Prealbumin	0.117	0.225	− 0.144	0.134	− 0.173	0.072
Disease severity and prognosis
APACHE II	0.060	0.533	0.168	0.081	0.109	0.261
SOFA	0.016	0.866	0.277	0.004**	0.205	0.033*
LOS in hospital	0.055	0.567	− 0.006	0.953	− 0.047	0.626
LOS in ICU	− 0.019	0.842	0.041	0.670	− 0.012	0.898
90-day mortality	–	0.905	–	0.038*	–	0.027*

HbA1c hemoglobin A1c, FBG fasting blood glucose, DAO diamine oxidase, LPS lipopolysaccharide, WBC white blood cell, NEU neutrophil, CRP C-reactive protein, RPM rate per minute, MAP mean arterial pressure, NE norepinephrine, AKI acute kidney injury, ALT alanine transaminase, AST aspartate transaminase, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, LOS length of stay
^*P < 0.05, **P < 0.01

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