Fig. 3From: Roles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetesThe molecular mechanisms of exercise-induced exosomal miR-126 for anti-inflammation in diabetes. Exercise-induced exosomes modify the downstream target genes IκBα, HMEB1, and VCAM-1 via their carried miR-126. The anti-inflammatory effects in diabetic cardiovascular system are achieved by inhibiting inflammatory substances, such as HMGB1 and TNF-a activate IKK to enhance phosphorylation of the NF-κB (p65 and p50) complex. Then NF-κB enters the nucleus via nuclear pore to stimulate IκBα genes and NF-κB target genes production, which can activate the NF-κB inflammatory pathwayBack to article page