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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression

Fig. 1

The rat model of type 2 diabetes mellitus (T2DM)-induced liver injury. Following 12 h of fasting, fasting blood glucose (FBG) was measured and T2DM was induced by nicotinamide (NIC; 110 mg/kg) and streptozotocin (STZ; 55 mg/kg) administration. T2DM was confirmed on day 3 after its induction. Diabetic rats received either oral administration of alpha-lipoic acid (T2DM + ALA; 60 mg/kg/day) or intraperitoneal injection of DL-propargylglycine (T2DM + PPG; 40 mg/kg/day) for 6 weeks. Untreated diabetic and non-diabetic rats received distilled water orally and served as diabetic (T2DM) and healthy control (HC) groups respectively. The rats were sacrificed after 6 weeks and samples were collected for analysis

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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