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Table 1 Characteristics of study participants

From: Metabolic syndrome and the immunogenicity of Pfizer–BioNTech vaccine: a cross-sectional study in Japanese healthcare workers

Characteristics

All participants

Metabolic syndrome

No

Yes

P values

N

946

895

51

 

Age (year), mean (SD)

36.7 (12.3)

35.9 (12.0)

49.5 (10.7)

 < 0.001

Sex (men)

298 (31.5)

271 (30.3)

27 (52.9)

0.001

Smoking

 Non-smoker

855 (90.4)

819 (91.5)

36 (70.6)

 < 0.001

 Smoker

91 (9.6)

76 (8.5)

15 (29.4)

Occupation

 Nurse

285 (30.1)

279 (31.2)

6 (11.8)

0.033

 Doctor

183 (19.3)

171 (19.0)

12 (23.5)

 Administrative staff

134 (14.2)

125 (14.0)

9 (17.6)

 Allied healthcare professionals

125 (13.2)

119 (13.3)

6 (11.8)

 Others

219 (23.2)

201 (22.5)

18 (35.3)

Alcohol consumption

 Non-drinker

355 (37.5)

332 (37.1)

23 (45.1)

0.24

 Drinker consuming

   < 23 g ethanol/day

442 (46.7)

424 (47.4)

18 (35.3)

 

   ≥ 23 g ethanol/day

149 (15.8)

139 (15.5)

10 (19.6)

 

Leisure time physical activity

 Non-engagement

197 (20.8)

185 (20.7)

12 (23.5)

0.49

 < 150 min/week

657 (69.5)

625 (69.8)

32 (62.7)

  ≥ 150 min/week

92 (9.7)

85 (9.5)

7 (13.7)

Comorbidities (any of the below)

29 (3.1)

25 (2.8)

4 (7.8)

0.11

 Lung disease

18 (1.9)

16 (1.8)

2 (3.9)

0.57

 Heart disease

5 (0.5)

4 (0.4)

1 (2.0)

0.64

 Cancer

6 (0.6)

5 (0.6)

1 (2.0)

0.75

History of SARS-Cov-2 infection a

5 (0.5)

5 (0.6)

0 (0.0)

-

Vaccine-to-IgG time, median (range) b

67 (15–103)

67 (15–103)

69 (35–98)

0.009

SARS-Cov-2 spike antibody titer (AU/mL), median (P25-P75)

5588 (3346, 9550)

5746 (3443, 9736)

2986 (1729, 5973)

 < 0.001

Body mass index (kg/m2), mean (SD)

21.6 (3.2)

21.4 (3.0)

26.6 (3.7)

 < 0.001

Waist circumference (cm), mean (SD)

76.5 (10.0)

75.6 (9.3)

92.8 (9.4)

 < 0.001

Systolic blood pressure (mm Hg), mean (SD)

117.4 (13.0)

116.7 (12.7)

130.4 (11.6)

 < 0.001

Diastolic blood pressure (mm Hg), mean (SD)

69.4 (10.0)

68.9 (9.7)

79.2 (9.9)

 < 0.001

Fasting blood glucose (mg/dL), mean (SD)

86.6 (16.2)

85.0 (7.7)

114.5 (55.2)

 < 0.001

High-density lipoprotein cholesterol (mg/dL), mean (SD)

70.1 (15.4)

70.9 (15.0)

55.9 (15.7)

 < 0.001

Triglycerides (mg/dL), median (P25-P75)

62.5 (44.0, 88.8)

61.0 (44.0, 85.0)

167.0 (100.5, 221.0)

 < 0.001

Use of lipid-lowering medication, n (%)

38 (4.0)

14 (1.6)

24 (47.1)

 < 0.001

Use of antihypertensive medication, n (%)

50 (5.3)

24 (2.7)

26 (51.0)

 < 0.001

Use of antidiabetic medication, n (%)

14 (1.5)

2 (0.2)

12 (23.5)

 < 0.001

  1. Values are n (%), unless otherwise stated
  2. P25-P75 25th–75th percentile range, AU antibody unit, SD standard deviation
  3. adefined as the positive result of either polymerase chain reaction test or the measurement of antibodies against SARS-CoV-2 nucleocapsid protein
  4. btime interval (in day) between the second dose of vaccine and the day of blood draw; P values obtained from t-tesst/ Chi-squared test