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Table 1 Demographic, clinical and laboratory data of the studied population

From: Biochemical and clinical markers of endothelial dysfunction do not outweigh traditional risk factors for the presence of diabetic retinopathy in patients with type 1 diabetes

Variables

N = 187

Female gender, n (%)

96 (51.3)

Age (years)

32.2 ± 13.9

Age at diagnosis (years)

15 [13]

Diabetes duration (years)

14 [15]

Daily insulin dose (U/Kg/day)

0.7 ± 0.3

Self-reported color-race, White, n (%)

95 (50.3)

Economic Status, n (%)

 Medium

25(13.4)

 Low

132 (70.6)

 Very Low

24(12.8)

 Age at menarche (years)

12 .3 ± 1.6

 Smoking, yes, n (%)

15 (8)

 Exercisea, y n (%)

82 (43.9)

 Abdominal circumference (women/men) (cm)

81 ± 11/ 82 ± 11

 BMI (kg/m2)

24.2 ± 4.1

 Systolic blood pressure (mmHg)

124 .7 ± 16.2

 Diastolic blood pressure (mmHg)

74.8 ± 9.8

 Pulse pressure (mmHg)

50.1 ± 12.4

 Cardiac frequency (bpm)

78.1 ± 12.5

HbA1c (%/mmol/mol)

9.1 ± 2.1/ 76 ± 2.2

Uric acid (mg/dL)

3.8 ± 1.5

Total Cholesterol (mg/dL)

173.7 ± 38.8

Triglycerides (mg/dL)

70 [56]

HDL-cholesterol (mg/dL)

61.8 ± 18.5

LDL-cholesterol (mg/dL)

92.8 ± 28.8

CRP (mg/dL)

0.20 [0.43]

Use of endothelial interferent drug, n (%)

81 (43.3)

sVCAM-1 (ng/mL)

370.6 [277.7]

sICAM-1 (ng/mL)

8.3 [13.7]

RHI

1.7 [0.9]

Cardiovascular risk, according to RHI, n (%)

 High CVR; RHI ≤ 1.67

88 (47.1%)

 Intermediate CVR, RHI 1.68–2.00

43 (23.0%)

 Low CVR, RHI ≥ 2.1

56 (29.9%)

Chronic complications

 Retinopathy, y n (%)

81 (44.4)

  Non-proliferative

57 (30.5)

  Proliferative

8 (4.3)

  Macular edema

16 (8.6)

 eGFR ((mL/min/1.73 m2)

106.2 (28.2)

  1. Data are expressed in mean ± standard deviation (SD) or median (Interquartil range, [IQR])
  2. IU international units, BMI body mass índex, HbA1c glycated hemoglobin, CRP C reactive protein, sVCAM-1 soluble vascular cytoadhesive molecule-1: (sVCAM-1), sICAM-1 intracellular cytoadhesive molecule-1, RHI reactive hyperemia index, CVR cardiovascular risk, eGFR Glomerular filtration rate, CKD chronic renal disease
  3. aExercise ≥ 3 times/week