Fig. 3From: Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationshipGestational diabetes mellitus (GDM) and thrombotic complications: GDM induces insulin resistance (IR) and release of pro-inflammatory cytokines (PICs), by which leads to hyperglycemia and hyperinsulinemia. These changes induce the expression of plasminogen activator inhibitor 1 (PAI-1) with subsequent hypofibrinolysis and thrombotic complicationsBack to article page