Fig. 2
From: Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationship
Role of plasminogen activator inhibitor 1 (PAI-1) in diabetes and obesity: Positive energy balance increase tumor necrosis factor-alpha (TNF-α) and PAI-1 leading to reduction in the expression of peroxisome proliferator activator receptor gamma (PPAR-γ) with subsequent development of insulin resistance (IR) and diabetes. Also, the reduction of PPAR-γ increases adipocyte hypertrophy and the development of obesity