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Table 3 Effect of intensive treatment compared with routine care on hemodynamic indices

From: Long-term effects of intensive multifactorial treatment on aortic stiffness and central hemodynamics after 13 years with screen-detected type 2 diabetes: the ADDITION-Denmark trial

 

Model 1

Model 2

Hemodynamic indices

Estimate (95% CI)

Estimate (95% CI)

Peripheral systolic blood pressure (mmHg)

− 3.38 (− 7.14 to 0.38)

− 3.34 (− 7.12 to 0.43)

Peripheral diasolic blood pressure (mmHg)

− 1.23 (− 3.21 to 0.76)

− 1.47 (− 3.4 to 0.45)

Peripheral pulse pressure (mmHg)

− 2.33 (− 5.28 to 0.62)

− 1.97 (− 4.83 to 0.89)

Central systolic blood pressure (mmHg)

− 3.06 (− 7.08 to 0.96)

− 2.85 (− 6.82 to 1.12)

Central diastolic blood pressure (mmHg)

− 1.70 (− 3.74 to 0.34)

− 1.85 (− 3.85 to 0.16)

Central pulse pressure (mmHg)

− 1.74 (− 4.79 to 1.31)

− 1.28 (− 4.11 to 1.55)

Central mean arterial pressure (mmHg)

− 2.14 (− 4.87 to 0.59)

− 2.19 (− 4.94 to 0.56)

Central augmentation index (%)

− 1.25 (− 3.28 to 0.78)

− 1.03 (− 2.85 to 0.79)

Pulse wave velocity (m/s)

− 0.58 (− 1.09 to − 0.06) †

− 0.48 (− 0.97 to 0.01)

Pulse wave velocity (m/s)*

− 0.47 (− 0.99 to 0.06)

− 0.35 (− 0.84 to 0.14)

  1. Model 1: Adjustment for heart rate at the time of assessment and cluster randomization. Model 2: Model 1 plus adjustment for age and sex
  2. *Model 1 and model 2 additionally adjusted for mean blood pressure at the time of assessment. Mean blood pressure was calculated as: peripheral diastolic blood pressure + (0.4* peripheral pulse pressure)
  3. p < 0.05