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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation

Fig. 5

Effect of EMPA on SCAP-SREBP-2 complexes in HK-2 cells. The translocation of GFP-SCAP from the ER to the Golgi was investigated using confocal microscopy after staining with anti-Golgi antibody. EMPA inhibited the translocation of GFP-SCAP from the ER to the Golgi in HK-2 cells (A). The interaction between SCAP and SREBP-2 proteins was investigated using Co-IP. AGEs-BSA increased the interactions of SCAP and SREBP-2 in HK-2 cells, whereas this could be inhibited by EMPA (B)

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