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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation

Fig. 2

Effects of EMPA on biochemical characteristics and renal morphology of diabetic mice. The levels of FBG (A), AGEs (B), TG (C), TC (D), SCR (E), BUN (F), u-NGAL (G) and 24-h urine protein (H) in mice. HE and PAS (I) staining in the kidneys of mice was observed under a light microscope (200×). The mesangial area was expressed quantitatively by calculating the percentage of the total glomerular area that was PAS positive. Fifteen glomerular tufts per animal were chosen randomly for analysis. The histogram represents the mesangial matrix index. The values are expressed as the mean ± S.E.M. of 5 independent experiments. *P < 0.05 and **P < 0.01 versus the db/m group; #P < 0.05 and ##P < 0.01 versus the db/db group; ▲P < 0.05 and ▲▲P < 0.01 versus the AGEs + db/db group; ns not significant

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