Table 7 Top 20 signaling pathway mediated by the identified genes
Term | Count | p-value | Gene symbol |
|---|---|---|---|
Toll-like receptor signaling pathway | 6 | 1.90E−07 | AKT2, IL12B, IL6, MAPK14, NFKB1, PIK3R1 |
Insulin resistance | 6 | 2.10E−07 | AKT2, IRS1, IRS2, IL6, NFKB1, PIK3R1 |
FoxO signaling pathway | 6 | 6.10E−07 | AKT2, IRS1, IRS2, IL6, MAPK14, PIK3R1 |
Non-alcoholic fatty liver disease (NAFLD) | 6 | 1.10E−06 | AKT2, IRS1, IRS2, IL6, NFKB1, PIK3R1 |
Influenza A | 6 | 2.20E−06 | AKT2, IL12B, IL6, MAPK14, NFKB1, PIK3R1 |
TNF signaling pathway | 5 | 1.10E−05 | AKT2, IL6, MAPK14, NFKB1, PIK3R1 |
Neurotrophin signaling pathway | 5 | 1.70E−05 | AKT2, IRS1, MAPK14, NFKB1, PIK3R1 |
Measles | 5 | 2.60E−05 | AKT2, IL12B, IL6, NFKB1, PIK3R1 |
Regulation of lipolysis in adipocytes | 4 | 5.90E−05 | AKT2, IRS1, IRS2, PIK3R1 |
Tuberculosis | 5 | 7.90E−05 | AKT2, IL12B, IL6, MAPK14, NFKB1 |
Inflammatory bowel disease (IBD) | 4 | 8.80E−05 | FOXP3, IL12B, IL6, NFKB1 |
Adipocytokine signaling pathway | 4 | 1.20E−04 | AKT2, IRS1, IRS2, NFKB1 |
Prolactin signaling pathway | 4 | 1.20E−04 | AKT2, MAPK14, NFKB1, PIK3R1 |
Pertussis | 4 | 1.40E−04 | IL12B, IL6, MAPK14, NFKB1 |
HIF-1 signaling pathway | 4 | 2.90E−04 | AKT2, IL6, NFKB1, PIK3R1 |
T cell receptor signaling pathway | 4 | 3.30E−04 | AKT2, MAPK14, NFKB1, PIK3R1 |
Amoebiasis | 4 | 3.90E−04 | IL12B, IL6, NFKB1, PIK3R1 |
Toxoplasmosis | 4 | 4.40E−04 | AKT2, IL12B, MAPK14, NFKB1 |
Sphingolipid signaling pathway | 4 | 5.70E−04 | AKT2, MAPK14, NFKB1, PIK3R1 |
AMPK signaling pathway | 4 | 6.10E−04 | AKT2, IRS1, IRS2, PIK3R1 |