Table 5 Significantly dysregulated genes in T2D + CHD vs. control groups
Symbol | Description | Fold change | p-value |
|---|---|---|---|
ACLY | ATP citrate lyase | ↑620.7109 | 0.008527 |
AKT2 | V-akt murine thymoma | ↑2786.8979 | 0.031769 |
AQP2 | Aquaporin 2 | ↑8.1555 | 0.045277 |
FOXP3 | Forkhead box P3 | ↑3.8489 | 0.047164 |
G6PD | Glucose-6-phosphate dehydrogenase | ↑13,256.7953 | 0.01726 |
GLP1R | Glucagon-like peptide 1 receptor | ↓0.0002 | 0.005732 |
GPD1 | Glycerol-3-phosphate dehydrogenase 1 (soluble) | ↓0.003 | 0.022912 |
GSK3B | Glycogen synthase kinase 3 beta | ↓0.0032 | 0.010075 |
HMOX1 | Heme oxygenase (decycling) 1 | ↓0.0008 | 0.007296 |
ICAM1 | Intercellular adhesion molecule 1 | ↓0.0001 | 0.001424 |
IDE | Insulin-degrading enzyme | ↓0.0063 | 0.003091 |
IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells | ↑438.9089 | 0.0001 |
IL12B | Interleukin 12B (natural killer cell stimulatory factor | ↑877.8178 | 0.040432 |
IL6 | Interleukin 6 (interferon, beta 2) | ↑1970.6344 | 0.011704 |
IRS1 | Insulin receptor substrate 1 | ↑2482.8438 | 0.034903 |
IRS2 | Insulin receptor substrate 2 | ↑828.5497 | 0.000069 |
MAPK14 | Mitogen-activated protein kinase 14 | ↑2630.4814 | 0.015893 |
NFKB1 | Nuclear factor of kappa light polypeptide Gene enhancer in B-cells 1 | ↑4686.9849 | 0.006946 |
PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 | ↑1315.2407 | 0.021226 |
STX4 | Syntaxin 4 | ↓0.0003 | 0.00881 |
TRIB3 | Tribbles homolog 3 (Drosophila) | ↓0.0084 | 0.044704 |