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Table 5 Significantly dysregulated genes in T2D + CHD vs. control groups

From: Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease

Symbol Description Fold change p-value
ACLY ATP citrate lyase ↑620.7109 0.008527
AKT2 V-akt murine thymoma ↑2786.8979 0.031769
AQP2 Aquaporin 2 ↑8.1555 0.045277
FOXP3 Forkhead box P3 ↑3.8489 0.047164
G6PD Glucose-6-phosphate dehydrogenase ↑13,256.7953 0.01726
GLP1R Glucagon-like peptide 1 receptor ↓0.0002 0.005732
GPD1 Glycerol-3-phosphate dehydrogenase 1 (soluble) ↓0.003 0.022912
GSK3B Glycogen synthase kinase 3 beta ↓0.0032 0.010075
HMOX1 Heme oxygenase (decycling) 1 ↓0.0008 0.007296
ICAM1 Intercellular adhesion molecule 1 ↓0.0001 0.001424
IDE Insulin-degrading enzyme ↓0.0063 0.003091
IKBKB Inhibitor of kappa light polypeptide gene enhancer in B-cells ↑438.9089 0.0001
IL12B Interleukin 12B (natural killer cell stimulatory factor ↑877.8178 0.040432
IL6 Interleukin 6 (interferon, beta 2) ↑1970.6344 0.011704
IRS1 Insulin receptor substrate 1 ↑2482.8438 0.034903
IRS2 Insulin receptor substrate 2 ↑828.5497 0.000069
MAPK14 Mitogen-activated protein kinase 14 ↑2630.4814 0.015893
NFKB1 Nuclear factor of kappa light polypeptide Gene enhancer in B-cells 1 ↑4686.9849 0.006946
PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 ↑1315.2407 0.021226
STX4 Syntaxin 4 ↓0.0003 0.00881
TRIB3 Tribbles homolog 3 (Drosophila) ↓0.0084 0.044704
  1. The symbol ↑ and ↓ reflect the genes up and down-regulation, respectively