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Table 3 List of significantly dysregulated genes in T2D vs. control groups

From: Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease

Symbol

Description

Fold change

p-value

ABCC8

ATP-binding cassette

↑50.7

0.00

ADRB3

Adrenergic, beta-3-, receptor

↑203.1

0.03

AGT

Angiotensinogen (serpin peptidase inhibitor)

↑10.67

0.008

AKT2

V-akt murine thymoma viral oncoGene homolog 2

↑120.8

0.027

AQP2

Aquaporin 2 (collecting duct)

↑456.1

0.000

CTLA4

Cytotoxic T-lymphocyte-associated protein 4

↑683.4

0.002

ENPP1

Ectonucleotide pyrophosphatase/phosphodiesterase 1

↑215.2

0.030

FBP1

Fructose-1,6-bisphosphatase 1

↑456.1

0.047

FOXC2

Forkhead box C2 (MFH-1, mesenchyme forkhead 1)

↑608.8

0.032

FOXP3

Forkhead box P3

↑683.438

0.005

G6PD

Glucose-6-phosphate dehydrogenase

↑16,007.9

0.009

GCGR

Glucagon receptor

↑95.8917

0.044

GLP1R

Glucagon-like peptide 1 receptor

↓0

0.027

GSK3B

Glycogen synthase kinase 3 beta

↓0

0.004

HMOX1

Heme oxygenase (decycling) 1

↓0.00

0.002

HNF1B

HNF1 homeobox B

↓0.00

0.007

ICAM1

Intercellular adhesion molecule 1

↓0.00

0.000

IDE

Insulin-degrading enzyme

↓0.002

0.00

IFNG

Interferon, gamma

↑287.3

0.014

IL10

Interleukin 10

↑1366.8

0.005

IL12B

Interleukin 12B (natural killer cell stimulatory factor 2)

↑362.03

0.04

IL4R

Interleukin 4 receptor

↑85.4

0.04

IL6

Interleukin 6 (interferon, beta 2)

↑1149.4

0.00

INSR

Insulin receptor

↑228.07

0.03

IRS1

Insulin receptor substrate 1

↑120.81

0.03

IRS2

Insulin receptor substrate 2

↑120.81

0.030

MAPK14

Mitogen-activated protein kinase 14

↑1084.8

0.046

ME1

Malic enzyme 1, NADP (+)-dependent, cytosolic

↑152.21

0.006

NFKB1

Nuclear factor of kappa light polypeptide Gene enhancer in B-cells 1

↑1824.5

0.026

PDX1

Pancreatic and duodenal homeobox 1

↑8

0.039

PIK3R1

Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

↑6501.9947

0.038

PPARGC1B

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta

↑107.6347

0.007

PRKAG2

Protein kinase, AMP-activated, gamma 2 non-catalytic subunit

↑574.7006

0.016

RAB4A

RAB4A, member RAS oncoGene family

↑3250.9974

0.001

RETN

Resistin

↑7732.2184

0.000

SLC2A4

Solute carrier family 2 (facilitated glucose transporter), member 4

↓0.7492

0.042

  1. The symbol ↑ and ↓ reflect the genes up and down-regulation, respectively