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Table 3 List of significantly dysregulated genes in T2D vs. control groups

From: Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease

Symbol Description Fold change p-value
ABCC8 ATP-binding cassette ↑50.7 0.00
ADRB3 Adrenergic, beta-3-, receptor ↑203.1 0.03
AGT Angiotensinogen (serpin peptidase inhibitor) ↑10.67 0.008
AKT2 V-akt murine thymoma viral oncoGene homolog 2 ↑120.8 0.027
AQP2 Aquaporin 2 (collecting duct) ↑456.1 0.000
CTLA4 Cytotoxic T-lymphocyte-associated protein 4 ↑683.4 0.002
ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase 1 ↑215.2 0.030
FBP1 Fructose-1,6-bisphosphatase 1 ↑456.1 0.047
FOXC2 Forkhead box C2 (MFH-1, mesenchyme forkhead 1) ↑608.8 0.032
FOXP3 Forkhead box P3 ↑683.438 0.005
G6PD Glucose-6-phosphate dehydrogenase ↑16,007.9 0.009
GCGR Glucagon receptor ↑95.8917 0.044
GLP1R Glucagon-like peptide 1 receptor ↓0 0.027
GSK3B Glycogen synthase kinase 3 beta ↓0 0.004
HMOX1 Heme oxygenase (decycling) 1 ↓0.00 0.002
HNF1B HNF1 homeobox B ↓0.00 0.007
ICAM1 Intercellular adhesion molecule 1 ↓0.00 0.000
IDE Insulin-degrading enzyme ↓0.002 0.00
IFNG Interferon, gamma ↑287.3 0.014
IL10 Interleukin 10 ↑1366.8 0.005
IL12B Interleukin 12B (natural killer cell stimulatory factor 2) ↑362.03 0.04
IL4R Interleukin 4 receptor ↑85.4 0.04
IL6 Interleukin 6 (interferon, beta 2) ↑1149.4 0.00
INSR Insulin receptor ↑228.07 0.03
IRS1 Insulin receptor substrate 1 ↑120.81 0.03
IRS2 Insulin receptor substrate 2 ↑120.81 0.030
MAPK14 Mitogen-activated protein kinase 14 ↑1084.8 0.046
ME1 Malic enzyme 1, NADP (+)-dependent, cytosolic ↑152.21 0.006
NFKB1 Nuclear factor of kappa light polypeptide Gene enhancer in B-cells 1 ↑1824.5 0.026
PDX1 Pancreatic and duodenal homeobox 1 ↑8 0.039
PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) ↑6501.9947 0.038
PPARGC1B Peroxisome proliferator-activated receptor gamma, coactivator 1 beta ↑107.6347 0.007
PRKAG2 Protein kinase, AMP-activated, gamma 2 non-catalytic subunit ↑574.7006 0.016
RAB4A RAB4A, member RAS oncoGene family ↑3250.9974 0.001
RETN Resistin ↑7732.2184 0.000
SLC2A4 Solute carrier family 2 (facilitated glucose transporter), member 4 ↓0.7492 0.042
  1. The symbol ↑ and ↓ reflect the genes up and down-regulation, respectively