Combined effect of pancreatic lipid content and gene variants (TCF7L2, WFS1 and 11BHSD1) on B-cell function in Middle Aged Women in a Post Hoc Analysis

Table 2 Correlations between PTGC and indices of -cell function stratified by type T2DM associated gene variants

Indices of β-cell function	Gene	Variant ID	Genotype^a (n)	Correlation			Interaction analysis^b
Indices of β-cell function	Gene	Variant ID	Genotype^a (n)	R	p_{(crude/corrected}^c₎	Power	p_{(crude/ corrected}^c₎
HOMA2-B	TCF7L2	rs7903146	CC (20)	0.51	0.022/0.044	0.664	0.001/0.003
			CT + TT (18)	− 0.32	0.20/0.20	0.263	0.001/0.003
	WFS1	rs1801214	TT^d (18)	0.09	0.71/0.71	0.065	0.18/ 0.18
			CT^d + CC (20)	0.55	0.013/0.044	0.745	0.18/ 0.18
	11ΒHSD1	rs4844880	TT (20)	− 0.05	0.82/0.82	0.055	0.029/0.044
			TA + AA (18)	0.56	0.016/0.044	0.714	0.029/0.044
AUC_insulin/AUC_glucose	TCF7L2	rs7903146	CC (20)	0.39	0.087/0.17	0.415	0.013/0.039
			CT + TT (18)	− 0.21	0.40/0.60	0.136	0.013/0.039
	WFS1	rs1801214	TT^d(18)	0.13	0.61/0.73	0.082	0.81/0.81
			CT^d + CC (20)	0.51	0.021/0.13	0.664	0.81/0.81
	11ΒHSD1	rs4844880	TT (20)	− 0.04	0.87/0.87	0.053	0.27/0.41
			TA + AA (18)	0.47	0.048/0.14	0.530	0.27/0.41

PTGC Pancreatic Triacylglycerol Content, T2DM type 2 diabetes mellitus, HOMA2-B Homeostasis Model Assessment 2-B, AUC Area Under the Curve
^aMajor allele homozygous vs. minor allele carriers;
^bLinear regression model. Outcome: insulin secretion marker, genotype in a dominant model (for minor allele) as a categorical and PTGC as a continuous variable. Interaction: categorical x continuous variable;
^cBenjamini-Hochberg (FDR) p-correction;
^dOnly C and T alleles detected in the Hungarian-Austrian cohort; multiallelic in GRCh38 assembly using the Ensembl browser “1000 Genomes” database [55]

ISSN: 1758-5996