Table 1 Baseline Samples Characteristics

Age (years)

61.5 ± 9.9

Education (school years)

7.5 ± 4.3

DM duration (years)

12.5 ± 8.3

Female (%)

52.2

White Race (%)

79.1

Married / Steady Union (%)

61.9

Physically Active (%)

30.6

Smoker/Former smoker (%)

42.5

Alcoholic/Former alcoholic (%)

33.6

Diastolic Blood Pressure (mmHg)

79.6 ± 11.3

Systolic Blood Pressure (mmHg)

129.4 ± 17.8

BMI (Kg/m2)

30.6 ± 4.9

Abdominal circumference (cm)

103.7 ± 12.2

Neck circumference (cm)

39.4 ± 4.2

Arterial hypertension (%)

79.1

Dyslipidemia (%)

92.5

Hypothyroidism (%)

28.4

Hyperthyroidism (%)

3.7

Cardiovascular disease (%)

28.4

Diabetic Retinopathy (%)

44.4

Macular edema (%)

11.1

Diabetic Neuropathy (%)

19.4

DM kidney disease (%)

47.7

Severe hypoglycemia (%)

21.6

Depression/Anxiety

17.9

PHQ-9 score > 9 (%)

39.6

Insulin Use (%)

61.9

Statins Use (%)

79.7

Urea (mg/dl) *

39.0(17.0)

Creatinine (mg/dl)*

0.9(0.4)

eGFR (ml/min/1.73m²) *

83.3(31.8)

Blood glucose (mg/dl)*

147.0(71.2)

HbA1c (%)*

7.8(2.3)

ACR (mg/g creatinine) *

17.7(49.6)

TSH (mU/L)*

2.1(1.7)

Free T4 (ng/dl)

1.1 ± 0.3

Triglycerides (mg/dl)*

153.0(119.0)

HDL cholesterol (mg/dl)*

42.0(13.0)

Total cholesterol (mg/dl)*

160.0(57.0)

LDL cholesterol (mg/dl)*

84.0(39.5)

Vitamin B12 (pg/ml)*

340.0(286.0)