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Table 1 Characteristics of study participants by quartiles of Osteocalcin

From: Circulating osteocalcin is associated with time in range and other metrics assessed by continuous glucose monitoring in type 2 diabetes

Variables

G1

G2

G3

G4

P

Number

94

94

94

94

 

Male/Female

M 60 F 34

M 62 F 32

M 59 F 35

M 54 F 40

 

Osteocalcin (ng/ml)

8.73 (7.50 9.82)

12.38 (11.43 13.19)*

15.10 (14.51 16.00)*#

21.20 (18.70 26.27)*#✱

 < 0.001

TBR (%)

0.00 (0.00 0.00)

0.00 (0.00 0.00)

0.00 (0.00 0.04)

0.00 (0.00 0.47)

0.71

TIR (%)

53.94 (34.01 70.93)

58.43 (40.47 76.11)

68.64 (34.76 86.93)*

72.20 (45.55 85.93)*#

0.001

TAR (%)

45.24 (29.07 64.29)

41.57 (23.15 59.44)

30.86 (13.03 62.84)*

26.74 (13.32 53.07)*#

0.001

Age (years)

55.68 ± 11.43

56.49 ± 11.13

53.27 ± 3.80

55.30 ± 12.84

0.403

Weight (Kg)

70.41 ± 12.30

70.25 ± 12.20

71.7 ± 12.63

68.15 ± 12.69

0.288

High (m)

1.66 ± 0.08

1.66 ± 0.08

1.68 ± 0.09

1.67 ± 0.09

0.467

BMI (kg/m2)

25.37 ± 3.62

25.03 ± 3.21

25.08 ± 3.27

24.74 ± 3.70

0.669

Creatinine (umol/L)

57.16 ± 16.34

58.02 ± 13.35

56.27 ± 14.87

59.24 ± 17.45

0.615

Duration (years)

7.00 (2.00 15.00)

8.00 (2.75 15.00)

6.00 (2.00 12.00)

6.00 (1.00 11.00)

0.419

SBP (mmHg)

130.00 (127.75 145.00)

130 (124.75 140.00)

130 (129.50 140.00)

130.00 (120.00 138.50)

0.499

DBP (mmHg)

78.00 (75.00 86.25)

79.00 (75.00 85.25)

79.00 (75.00 87.50)

78.00 (74.00 82.25)

0.705

K (mmol/L)

3.82 ± 0.37

3.8 ± 0.33

3.86 ± 0.32

3.84 ± 0.29

0.581

Ca (mmol/L)

2.21 ± 0.12

2.24 ± 0.12

2.21 ± 0.10

2.19 ± 0.11

0.053

TC (mmol/L)

4.42 ± 1.14

4.63 ± 1.07

4.56 ± 0.95

4.71 ± 1.04

0.297

TG (mmol/L)

1.53 (1.10 2.32)

1.61 (1.12 2.28)

1.50 (1.10 2.35)

1.44 (1.01 1.98)

0.602

HbA1C (%)

9.25 ± 1.73

9.00 ± 1.98

8.62 ± 2.21*

8.49 ± 1.94*

0.045

Vit D (ng/ml)

24.11 ± 6.84

25.56 ± 6.64

25.15 ± 6.86

23.73 ± 6.27

0.218

MBG (mmol⁄ L)

10.35 ± 2.02

9.89 ± 2.12

9.53 ± 2.49*

9.21 ± 1.79*#

0.002

SD

2.86 ± 1.01

2.59 ± 0.99

2.35 ± 0.88*

2.44 ± 0.97*

0.008

CV

0.28 ± 0.08

0.28 ± 0.10

0.24 ± 0.06*#

0.26 ± 0.08✱

 < 0.001

LBGI

0.37 (0.00 1.74)

0.50 (0.05 1.50)

0.37 (0.01 1.03)

0.74 (0.21 1.81)*✱

0.043

HBGI

10.26 (7.08 14.40)

9.61 (6.07 13.82)

7.13 (3.61 13.82)*

6.74 (3.75 12.87)*#

0.002

MAGE (mmol⁄ L)

5.30 ± 2.03

4.78 ± 1.76

4.75 ± 1.72

4.89 ± 1.69

0.171

ADDR (mmol⁄ L)

27.27 (20.61 37.24)

25.31 (18.53 32.40)

20.84 (13.91 32.64)*

21.29 (13.15 31.86)*

0.001

MODD (mmol⁄ L)

2.44 (1.68 3.37)

2.38 (1.76 3.52)

2.07 (1.35 2.56)*#

2.05 (1.43 3.16)

0.003

  1. Data are presented as means ± SD, median (25% and 75%interquartiles), and count (percentages) according to characteristics of the distribution. Between-group, comparisons were conducted by One-way ANOVA, Kruskal- Wallis H test, and the chi-squared test
  2. BMI: body mass index, TC: total cholesterol, TG: triglycerides, SBP: systolic blood pressure, DBP: diastolic blood pressure, HbA1c: hemoglobin A1C, TIR: time in range, TBR: time below range, TAR: time above range, CV: coefficient variation, SD: standard deviation, LBGI: low blood glucose index, HBGI: high blood glucose index, MAGE: mean amplitude of glucose excursions, ADDR: average daily danger range, MODD: mean of daily differences
  3. *Significant difference with group 1(P < 0.05)
  4. #Significant difference with group 2(P < 0.05)
  5. Significant difference with group 3(P < 0.05)