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Table 2 Use of the Myoinositol versus Placebo

From: Myo-inositol supplementation for prevention of gestational diabetes mellitus in overweight and obese pregnant women: a systematic review and meta-analysis

No. of studies Design Risk of bias Inconsistency Indirectness Imprecision Other considerations Use of the MI No Use of the MI Pooled effect Relativea [95% CI] Final judgment
Gestational diabetes rate [GDM Rate]
4 RCTs Seriousb No serious No serious No serious No serious 38/339 99/351 OR 0.32 [0.21 to 0.]48] Ο MODERATE
FG-OGTT
4 RCTs Seriousb No serious No serious No serious No serious 339 351 MD 2.64 lower [4.12 to 1.17 lower] Ο MODERATE
1 h-OGTT
4 RCTs Seriousb No serious No serious No serious No serious 339 351 MD 7.47 lower [12.24 to 2.31 lower] ΟΟ LOW
2 h-OGTT
4 RCTs Seriousb Serious2 No serious No serious No serious 339 351 MD 10.51 lower [16.88 to 4.14 lower] ΟΟ LOW
Gestational hypertension
4 RCTs Seriousb No serious No serious No serious No serious 9/339 35/351 OR 0.26 [0.13 to 0.56] Ο MODERATE
Preterm labor
3 RCTs Seriousb No serious No serious Seriousd No serious 7/229 21/238 OR 0.33 [0.14 to 0.81] ΟΟ LOW
Cesarean section rate
3 RCTs Seriousb No serious No serious Seriousd No serious 97/229 116/238 OR 0.77 [0.53 to 1.12] ΟΟ LOW
Macrosomia
3 RCTs Seriousb No serious No serious Seriousd No serious 8/229 12/238 OR 0.74 [0.28 to 1.95] ΟΟ LOW
Neonatal hypoglycemia
2 RCTs Seriousb No serious No serious Very seriousd No serious 0/202 2/209 OR 0.34 [0.04 to 3.32] ΟΟΟ VERY LOW
NICU admission
3 RCTs Seriousb No serious No serious Seriousd No serious 3/229 11/238 OR 0.36 [0.10 to 1.32] ΟΟ LOW
Shoulder dystocia
3 RCTs Seriousb No serious No serious Very seriousd No serious 1/229 2/238 OR 0.64 [0.08 to 5.25] ΟΟΟ VERY LOW
  1. GRADE Working Group grades of evidence
  2. High quality: We are very confident that the true effect lies close to that of the estimate of the effect
  3. Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  4. Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
  5. Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  6. CI confidence interval, OR odds ratio, OGTT oral glucose tolerance test, NICU neonatal intensive care unit admission
  7. aThe risk in the intervention group [and its 95% confidence interval] is based on the assumed risk in the comparison group and the relative effect of the intervention [and its 95% CI]
  8. bStudies at high risk of bias
  9. cSevere unexplained heterogeneity
  10. dWide confidence interval [CI] crossing the line of no effect
  11. eSmall sample size and/or few events