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Table 3 Association between SUA changes and incident MetS by gender

From: Temporal changes in serum uric acid and risk for metabolic syndrome: a longitudinal cohort study

Categories Event/total Unadjusted model
HR (95%CI) P Value
Model 1
HR (95%CI) P Value
Model 2
HR (95%CI) P Value
Men     
 Longitudinal absolute changes of SUA     
  Q1 (< − 32 μmol/L) 742/4289 1 (reference)   1 (reference)   1 (reference)  
  Q2 (− 32 to < − 6 μmol/L) 711/4493 0.90 (0.81, 1.00) 0.046 1.14 (1.03, 1.27) 0.012 1.14 (1.02, 1.26) 0.016
  Q3 (− 6 to < 15 μmol/L) 723/4234 0.99 (0.89, 1.10) 0.876 1.38 (1.24, 1.53)  < 0.001 1.38 (1.24, 1.53)  < 0.001
  Q4 (15 to < 42 μmol/L) 793/4557 0.99 (0.90, 1.10) 0.878 1.46 (1.31, 1.62)  < 0.001 1.45 (1.30, 1.61)  < 0.001
  Q5 (≥ 42 μmol/L) 873/4399 1.10 (1.00, 1.22) 0.050 1.72 (1.55, 1.91)  < 0.001 1.70 (1.53, 1.89)  < 0.001
  P for trend    0.007    < 0.001    < 0.001
  Per 10 units increase 3842/21972 1.01 (1.00, 1.01) 0.022 1.04 (1.03, 1.05)  < 0.001 1.04 (1.03, 1.05)  < 0.001
 Longitudinal percent changes of SUA      
  Q1 (< − 8.39%) 704/4393 1 (reference)   1 (reference)   1 (reference)  
  Q2 (− 8.39% to < − 1.77%) 738/4399 1.03 (0.93, 1.15) 0.543 1.18 (1.07, 1.31) 0.002 1.18 (1.06, 1.31) 0.002
  Q3 (− 1.77% to < 4.37%) 788/4394 1.14 (1.03, 1.26) 0.014 1.41 (1.27, 1.56)  < 0.001 1.41 (1.27, 1.56)  < 0.001
  Q4 (4.37% to < 12.14%) 800/4388 1.12 (1.02, 1.24) 0.023 1.51 (1.36, 1.68)  < 0.001 1.50 (1.35, 1.66)  < 0.001
  Q5 (≥ 12.14%) 812/4398 1.10 (1.00, 1.22) 0.062 1.76 (1.58, 1.96)  < 0.001 1.74 (1.56, 1.94)  < 0.001
  P for trend    0.018    < 0.001  < 0.001  
  Per 10% increase 3842/21972 1.03 (1.00, 1.05) 0.027 1.16 (1.13, 1.19)  < 0.001 1.16 (1.13, 1.19)  < 0.001
Women        
 Longitudinal absolute changes of SUA     
  Q1 (< − 28 μmol/L) 264/4328 1 (reference)   1 (reference)   1 (reference)  
  Q2 (− 28 to < − 5 μmol/L) 290/4422 1.05 (0.89, 1.25) 0.541 1.38 (1.17, 1.64)  < 0.001 1.40 (1.18, 1.66)  < 0.001
  Q3 (− 5 to < 14 μmol/L) 285/4360 1.03 (0.87, 1.21) 0.772 1.47 (1.23, 1.75)  < 0.001 1.47 (1.23, 1.75)  < 0.001
  Q4 (14 to < 37 μmol/L) 338/4516 1.14 (0.97, 1.33) 0.120 1.68 (1.41, 1.99)  < 0.001 1.63 (1.37, 1.94)  < 0.001
  Q5 (≥ 37 μmol/L) 442/4578 1.36 (1.17, 1.58)  < 0.001 2.03 (1.73, 2.39)  < 0.001 1.94 (1.65, 2.28)  < 0.001
  P for trend    < 0.001    < 0.001    < 0.001
  Per 10 units increase 1619/22204 1.03 (1.02, 1.04)  < 0.001 1.05 (1.04, 1.07)  < 0.001 1.05 (1.04, 1.06) 0.011
 Longitudinal percent changes of SUA    
  Q1 (< − 10.19%) 242/4441 1 (reference)   1 (reference)   1 (reference)  
  Q2 (− 10.19 to < − 1.90%) 316/4442 1.29 (1.09, 1.52) 0.003 1.48 (1.25, 1.76)  < 0.001 1.44 (1.22, 1.71)  < 0.001
  Q3 (− 1.90% to < 5.75%) 319/4443 1.26 (1.06, 1.49) 0.007 1.50 (1.26, 1.78)  < 0.001 1.49 (1.26, 1.77)  < 0.001
  Q4 (5.75% to < 15.29%) 358/4435 1.38 (1.17, 1.62)  < 0.001 1.79 (1.51, 2.13)  < 0.001 1.70 (1.43, 2.01)  < 0.001
  Q5 (≥ 15.29%) 384/4443 1.37 (1.16, 1.61)  < 0.001 2.13 (1.79, 2.53)  < 0.001 2.01 (1.69, 2.39)  < 0.001
 P for trend     < 0.001    < 0.001    < 0.001
 Per 10% increase 1619/22204 1.05 (1.02, 1.08)  < 0.001 1.16 (1.12, 1.19)  < 0.001 1.15 (1.11, 1.18)  < 0.001
  1. SUA serum uric acid, MetS metabolic syndrome, CI confidence interval, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, SCr serum creatinine
  2. Model 1: adjusted for baseline age, smoking status, drinking status, SUA
  3. Model 2: adjusted for baseline TC, LDL-C, and SCr, in addition to covariates in Model 1