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Table 3 Association between SUA changes and incident MetS by gender

From: Temporal changes in serum uric acid and risk for metabolic syndrome: a longitudinal cohort study

Categories

Event/total

Unadjusted model

HR (95%CI) P Value

Model 1

HR (95%CI) P Value

Model 2

HR (95%CI) P Value

Men

    

 Longitudinal absolute changes of SUA

    

  Q1 (< − 32 μmol/L)

742/4289

1 (reference)

 

1 (reference)

 

1 (reference)

 

  Q2 (− 32 to < − 6 μmol/L)

711/4493

0.90 (0.81, 1.00)

0.046

1.14 (1.03, 1.27)

0.012

1.14 (1.02, 1.26)

0.016

  Q3 (− 6 to < 15 μmol/L)

723/4234

0.99 (0.89, 1.10)

0.876

1.38 (1.24, 1.53)

 < 0.001

1.38 (1.24, 1.53)

 < 0.001

  Q4 (15 to < 42 μmol/L)

793/4557

0.99 (0.90, 1.10)

0.878

1.46 (1.31, 1.62)

 < 0.001

1.45 (1.30, 1.61)

 < 0.001

  Q5 (≥ 42 μmol/L)

873/4399

1.10 (1.00, 1.22)

0.050

1.72 (1.55, 1.91)

 < 0.001

1.70 (1.53, 1.89)

 < 0.001

  P for trend

  

0.007

 

 < 0.001

 

 < 0.001

  Per 10 units increase

3842/21972

1.01 (1.00, 1.01)

0.022

1.04 (1.03, 1.05)

 < 0.001

1.04 (1.03, 1.05)

 < 0.001

 Longitudinal percent changes of SUA

     

  Q1 (< − 8.39%)

704/4393

1 (reference)

 

1 (reference)

 

1 (reference)

 

  Q2 (− 8.39% to < − 1.77%)

738/4399

1.03 (0.93, 1.15)

0.543

1.18 (1.07, 1.31)

0.002

1.18 (1.06, 1.31)

0.002

  Q3 (− 1.77% to < 4.37%)

788/4394

1.14 (1.03, 1.26)

0.014

1.41 (1.27, 1.56)

 < 0.001

1.41 (1.27, 1.56)

 < 0.001

  Q4 (4.37% to < 12.14%)

800/4388

1.12 (1.02, 1.24)

0.023

1.51 (1.36, 1.68)

 < 0.001

1.50 (1.35, 1.66)

 < 0.001

  Q5 (≥ 12.14%)

812/4398

1.10 (1.00, 1.22)

0.062

1.76 (1.58, 1.96)

 < 0.001

1.74 (1.56, 1.94)

 < 0.001

  P for trend

  

0.018

 

 < 0.001

 < 0.001

 

  Per 10% increase

3842/21972

1.03 (1.00, 1.05)

0.027

1.16 (1.13, 1.19)

 < 0.001

1.16 (1.13, 1.19)

 < 0.001

Women

       

 Longitudinal absolute changes of SUA

    

  Q1 (< − 28 μmol/L)

264/4328

1 (reference)

 

1 (reference)

 

1 (reference)

 

  Q2 (− 28 to < − 5 μmol/L)

290/4422

1.05 (0.89, 1.25)

0.541

1.38 (1.17, 1.64)

 < 0.001

1.40 (1.18, 1.66)

 < 0.001

  Q3 (− 5 to < 14 μmol/L)

285/4360

1.03 (0.87, 1.21)

0.772

1.47 (1.23, 1.75)

 < 0.001

1.47 (1.23, 1.75)

 < 0.001

  Q4 (14 to < 37 μmol/L)

338/4516

1.14 (0.97, 1.33)

0.120

1.68 (1.41, 1.99)

 < 0.001

1.63 (1.37, 1.94)

 < 0.001

  Q5 (≥ 37 μmol/L)

442/4578

1.36 (1.17, 1.58)

 < 0.001

2.03 (1.73, 2.39)

 < 0.001

1.94 (1.65, 2.28)

 < 0.001

  P for trend

 

 < 0.001

 

 < 0.001

 

 < 0.001

  Per 10 units increase

1619/22204

1.03 (1.02, 1.04)

 < 0.001

1.05 (1.04, 1.07)

 < 0.001

1.05 (1.04, 1.06)

0.011

 Longitudinal percent changes of SUA

   

  Q1 (< − 10.19%)

242/4441

1 (reference)

 

1 (reference)

 

1 (reference)

 

  Q2 (− 10.19 to < − 1.90%)

316/4442

1.29 (1.09, 1.52)

0.003

1.48 (1.25, 1.76)

 < 0.001

1.44 (1.22, 1.71)

 < 0.001

  Q3 (− 1.90% to < 5.75%)

319/4443

1.26 (1.06, 1.49)

0.007

1.50 (1.26, 1.78)

 < 0.001

1.49 (1.26, 1.77)

 < 0.001

  Q4 (5.75% to < 15.29%)

358/4435

1.38 (1.17, 1.62)

 < 0.001

1.79 (1.51, 2.13)

 < 0.001

1.70 (1.43, 2.01)

 < 0.001

  Q5 (≥ 15.29%)

384/4443

1.37 (1.16, 1.61)

 < 0.001

2.13 (1.79, 2.53)

 < 0.001

2.01 (1.69, 2.39)

 < 0.001

 P for trend

  

 < 0.001

 

 < 0.001

 

 < 0.001

 Per 10% increase

1619/22204

1.05 (1.02, 1.08)

 < 0.001

1.16 (1.12, 1.19)

 < 0.001

1.15 (1.11, 1.18)

 < 0.001

  1. SUA serum uric acid, MetS metabolic syndrome, CI confidence interval, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, SCr serum creatinine
  2. Model 1: adjusted for baseline age, smoking status, drinking status, SUA
  3. Model 2: adjusted for baseline TC, LDL-C, and SCr, in addition to covariates in Model 1
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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