Variables | N0. | Case/ | C-allele vs. G-allele | CG vs. GG | ||||
---|---|---|---|---|---|---|---|---|
Control | OR(95%CI) | Ph | P | OR (95% CI) | Ph | P | ||
T2DM | Â | Â | Â | Â | Â | Â | Â | Â |
 Total | 34 | 7257/15598 | 0.88 (0.76–1.01) | 0.000 | 0.075 | 0.91 (0.77–1.08) | 0.000 | 0.281 |
 HWE | 25 | 5927/14023 | 0.98 (0.84–1.15) | 0.000 | 0.832 | 0.97 (0.83–1.13) | 0.000 | 0.687 |
 Ethnicity |  |  |  |  |  |  |  |  |
  Asian | 14 | 2595/2208 | 0.76 (0.58–0.99) | 0.000 | 0.039 | 0.99 (0.73–1.32) | 0.002 | 0.925 |
  Caucasian | 12 | 3767/12090 | 0.96 (0.81–1.12) | 0.000 | 0.579 | 0.95 (0.73–1.22) | 0.000 | 0.683 |
  Mixed | 5 | 582/846 | 1.09 (0.55–2.19) | 0.000 | 0.804 | 0.74 (0.58–0.94) | 0.154 | 0.014 |
  African | 3 | 313/454 | 0.83 (0.37–1.89) | 0.000 | 0.665 | 0.91 (0.77–1.08) | 0.041 | 0.486 |
 SOC |  |  |  |  |  |  |  |  |
  HB | 23 | 3546/9186 | 0.83 (0.68–1.01) | 0.000 | 0.059 | 0.95 (0.73–1.23) | 0.000 | 0.706 |
  PB | 11 | 3711/6412 | 0.98 (0.79–1.22) | 0.000 | 0.874 | 0.89 (0.75–1.05) | 0.100 | 0.166 |
 Ethnicity (with HWE) |  |  |  |  |  |  |  |  |
  Asian | 10 | 1887/1922 | 0.83 (0.59–1.17) | 0.000 | 0.283 | 0.97 (0.81–1.17) | 0.115 | 0.778 |
  Caucasian | 9 | 3458/11255 | 1.06 (0.91–1.25) | 0.001 | 0.443 | 1.15 (0.90–1.47) | 0.001 | 0.257 |
  Mixed | 5 | 582/846 | 1.09 (0.55–2.19) | 0.000 | 0.804 | 0.74 (0.58–0.94) | 0.154 | 0.014 |
SOC (with HWE) | Â | Â | Â | Â | Â | Â | Â | Â |
  HB | 16 | 2325/7749 | 0.97 (0.76–1.24) | 0.000 | 0.788 | 1.07 (0.82–1.39) | 0.001 | 0.635 |
  PB | 9 | 3602/6274 | 1.01 (0.81–1.26) | 0.000 | 0.907 | 0.90 (0.76–1.07) | 0.086 | 0.221 |
T1DM | Â | Â | Â | Â | Â | Â | Â | Â |
 Total | 12 | 10,264/9031 | 1.17 (0.96–1.42) | 0.000 | 0.120 | 1.32 (1.01–1.74) | 0.000 | 0.043 |
 HWE | 10 | 10,004/8763 | 1.13 (0.91–1.41) | 0.000 | 0.268 | 1.24 (0.96–1.61) | 0.002 | 0.100 |
 Ethnicity |  |  |  |  |  |  |  |  |
  Caucasian | 7 | 9737/8462 | 1.06 (0.81–1.38) | 0.000 | 0.682 | 1.37 (0.90–2.11) | 0.000 | 0.146 |
  Mixed | 3 | 406/405 | 1.39 (1.10–1.77) | 0.497 | 0.006 | 1.33 (0.99–1.79) | 0.835 | 0.059 |
 SOC |  |  |  |  |  |  |  |  |
  HB | 4 | 497/510 | 1.29 (1.07–1.56) | 0.122 | 0.009 | 1.47 (1.11–1.94) | 0.428 | 0.008 |
  PB | 8 | 9767/8521 | 1.15 (0.89–1.48) | 0.000 | 0.276 | 1.27 (0.88–1.82) | 0.000 | 0.195 |
 Ethnicity (with HWE) |  |  |  |  |  |  |  |  |
  Caucasian | 6 | 9527/8292 | 0.99 (0.74–1.34) | 0.000 | 0.971 | 1.21 (0.80–1.82) | 0.001 | 0.368 |
  Mixed | 3 | 406/405 | 1.39 (1.10–1.77) | 0.497 | 0.006 | 1.33 (0.99–1.79) | 0.835 | 0.059 |
SOC (with HWE) | Â | Â | Â | Â | Â | Â | Â | Â |
  HB | 4 | 497/510 | 1.29 (1.07–1.56) | 0.122 | 0.009 | 1.47 (1.11–1.94) | 0.428 | 0.008 |
  PB | 6 | 9507/8253 | 1.09 (0.80–1.49) | 0.000 | 0.578 | 1.13 (0.81–1.58) | 0.010 | 0.460 |
Variables | CC + CG vs. GG | CC vs. GG | CC vs. CG + GG | ||||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | |
T2DM | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Total | 0.87 (0.73–1.03) | 0.000 | 0.039 | 0.76 (0.57–1.02) | 0.000 | 0.039 | 0.82 (0.63–1.07) | 0.000 | 0.039 |
 HWE | 0.98 (0.82–1.16) | 0.000 | 0.786 | 0.98 (0.72–1.33) | 0.000 | 0.905 | 0.99 (0.76–1.29) | 0.000 | 0.962 |
 Ethnicity |  |  |  |  |  |  |  |  |  |
  Asian | 0.82 (0.61–1.11) | 0.000 | 0.208 | 0.45 (0.24–0.85) | 0.000 | 0.014 | 0.48 (0.27–0.86) | 0.000 | 0.014 |
  Caucasian | 0.93 (0.72–1.20) | 0.000 | 0.569 | 0.94 (0.74–1.19) | 0.043 | 0.595 | 0.98 (0.89–1.10) | 0.513 | 0.778 |
  Mixed | 0.94 (0.53–1.67) | 0.000 | 0.833 | 1.25 (0.30–5.19) | 0.000 | 0.759 | 1.38 (0.35–5.54) | 0.000 | 0.645 |
  African | 0.71 (0.23–2.13) | 0.003 | 0.536 | 0.99 (0.15–6.34) | 0.002 | 0.991 | 1.22 (0.22–6.67) | 0.000 | 0.818 |
 SOC |  |  |  |  |  |  |  |  |  |
  HB | 0.85 (0.66–1.10) | 0.000 | 0.227 | 0.61 (0.41–0.90) | 0.000 | 0.014 | 0.64 (0.46–0.90) | 0.000 | 0.011 |
  PB | 0.92 (0.73–1.14) | 0.001 | 0.430 | 1.08 (0.68–1.71) | 0.000 | 0.751 | 1.21 (0.79–1.85) | 0.000 | 0.373 |
 Ethnicity (with HWE) |  |  |  |  |  |  |  |  |  |
  Asian | 0.82 (0.56–1.20) | 0.002 | 0.303 | 0.62 (0.28–1.38) | 0.000 | 0.241 | 0.72 (0.38–1.35) | 0.004 | 0.305 |
  Caucasian | 1.13 (0.89–1.44) | 0.000 | 0.316 | 1.01 (0.80–1.28) | 0.098 | 0.918 | 1.00 (0.90–1.12) | 0.495 | 0.979 |
  Mixed | 0.94 (0.53–1.67) | 0.000 | 0.833 | 1.25 (0.30–5.19) | 0.000 | 0.759 | 1.38 (0.35–5.54) | 0.000 | 0.645 |
SOC (with HWE) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  HB | 1.01 (0.75–1.37) | 0.000 | 0.932 | 0.85 (0.53–1.36) | 0.000 | 0.493 | 0.85 (0.60–1.21) | 0.026 | 0.369 |
  PB | 0.96 (0.77–1.18) | 0.003 | 0.677 | 1.13 (0.72–1.79) | 0.000 | 0.590 | 0.99 (0.78–1.80) | 0.000 | 0.426 |
T1DM | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Total | 1.32 (0.99–1.76) | 0.000 | 0.060 | 1.40 (0.90–2.18) | 0.000 | 0.134 | 1.12 (0.83–1.50) | 0.005 | 0.463 |
 HWE | 1.25 (0.94–1.67) | 0.000 | 0.131 | 1.27 (0.78–2.05) | 0.000 | 0.331 | 1.04 (0.74–1.45) | 0.014 | 0.839 |
 Ethnicity |  |  |  |  |  |  |  |  |  |
  Caucasian | 1.30 (0.83–2.01) | 0.000 | 0.249 | 1.31 (0.67–1.92) | 0.000 | 0.645 | 0.93 (0.69–1.23) | 0.024 | 0.598 |
  Mixed | 1.43 (1.07–1.90) | 0.724 | 0.015 | 2.45 (1.18–5.07) | 0.486 | 0.016 | 2.20 (1.08–4.48) | 0.487 | 0.031 |
 SOC |  |  |  |  |  |  |  |  |  |
  HB | 1.51 (1.15–1.98) | 0.337 | 0.003 | 1.77 (1.14–2.74) | 0.128 | 0.010 | 1.16 (0.57–2.35) | 0.066 |  |
  PB | 1.27 (0.86–1.86) | 0.000 | 0.229 | 1.33 (0.77–2.32) | 0.000 | 0.312 | 1.10 (0.77–1.57) | 0.013 | 0.611 |
 Ethnicity (with HWE) |  |  |  |  |  |  |  |  |  |
  Caucasian | 1.15 (0.74–1.78) | 0.00 | 0.540 | 0.99 (0.56–1.75) | 0.000 | 0.968 | 0.88 (0.61–1.25) | 0.018 | 0.465 |
  Mixed | 1.43 (1.07–1.90) | 0.724 | 0.015 | 2.45 (1.18–5.07) | 0.486 | 0.016 | 2.20 (1.08–4.48) | 0.487 | 0.031 |
SOC (with HWE) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
  HB | 1.51 (1.15–1.98) | 0.337 | 0.003 | 1.77 (1.14–2.74) | 0.128 | 0.010 | 1.16 (0.57–2.35) | 0.066 | 0.680 |
  PB | 1.14 (0.78–1.68) | 0.000 | 0.494 | 1.11 (0.59–2.10) | 0.001 | 0.746 | 0.97 (0.62–1.50) | 0.041 | 0.887 |