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Table 3 Stratified analyses of IL-6 rs1800795 polymorphism and T2DM and T1DM risk

From: IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis

Variables

N0.

Case/

C-allele vs. G-allele

CG vs. GG

Control

OR(95%CI)

Ph

P

OR (95% CI)

Ph

P

T2DM

        

 Total

34

7257/15598

0.88 (0.76–1.01)

0.000

0.075

0.91 (0.77–1.08)

0.000

0.281

 HWE

25

5927/14023

0.98 (0.84–1.15)

0.000

0.832

0.97 (0.83–1.13)

0.000

0.687

 Ethnicity

        

  Asian

14

2595/2208

0.76 (0.58–0.99)

0.000

0.039

0.99 (0.73–1.32)

0.002

0.925

  Caucasian

12

3767/12090

0.96 (0.81–1.12)

0.000

0.579

0.95 (0.73–1.22)

0.000

0.683

  Mixed

5

582/846

1.09 (0.55–2.19)

0.000

0.804

0.74 (0.58–0.94)

0.154

0.014

  African

3

313/454

0.83 (0.37–1.89)

0.000

0.665

0.91 (0.77–1.08)

0.041

0.486

 SOC

        

  HB

23

3546/9186

0.83 (0.68–1.01)

0.000

0.059

0.95 (0.73–1.23)

0.000

0.706

  PB

11

3711/6412

0.98 (0.79–1.22)

0.000

0.874

0.89 (0.75–1.05)

0.100

0.166

 Ethnicity (with HWE)

        

  Asian

10

1887/1922

0.83 (0.59–1.17)

0.000

0.283

0.97 (0.81–1.17)

0.115

0.778

  Caucasian

9

3458/11255

1.06 (0.91–1.25)

0.001

0.443

1.15 (0.90–1.47)

0.001

0.257

  Mixed

5

582/846

1.09 (0.55–2.19)

0.000

0.804

0.74 (0.58–0.94)

0.154

0.014

SOC (with HWE)

        

  HB

16

2325/7749

0.97 (0.76–1.24)

0.000

0.788

1.07 (0.82–1.39)

0.001

0.635

  PB

9

3602/6274

1.01 (0.81–1.26)

0.000

0.907

0.90 (0.76–1.07)

0.086

0.221

T1DM

        

 Total

12

10,264/9031

1.17 (0.96–1.42)

0.000

0.120

1.32 (1.01–1.74)

0.000

0.043

 HWE

10

10,004/8763

1.13 (0.91–1.41)

0.000

0.268

1.24 (0.96–1.61)

0.002

0.100

 Ethnicity

        

  Caucasian

7

9737/8462

1.06 (0.81–1.38)

0.000

0.682

1.37 (0.90–2.11)

0.000

0.146

  Mixed

3

406/405

1.39 (1.10–1.77)

0.497

0.006

1.33 (0.99–1.79)

0.835

0.059

 SOC

        

  HB

4

497/510

1.29 (1.07–1.56)

0.122

0.009

1.47 (1.11–1.94)

0.428

0.008

  PB

8

9767/8521

1.15 (0.89–1.48)

0.000

0.276

1.27 (0.88–1.82)

0.000

0.195

 Ethnicity (with HWE)

        

  Caucasian

6

9527/8292

0.99 (0.74–1.34)

0.000

0.971

1.21 (0.80–1.82)

0.001

0.368

  Mixed

3

406/405

1.39 (1.10–1.77)

0.497

0.006

1.33 (0.99–1.79)

0.835

0.059

SOC (with HWE)

        

  HB

4

497/510

1.29 (1.07–1.56)

0.122

0.009

1.47 (1.11–1.94)

0.428

0.008

  PB

6

9507/8253

1.09 (0.80–1.49)

0.000

0.578

1.13 (0.81–1.58)

0.010

0.460

Variables

CC + CG vs. GG

CC vs. GG

CC vs. CG + GG

OR (95% CI)

Ph

P

OR (95% CI)

Ph

P

OR (95% CI)

Ph

P

T2DM

         

 Total

0.87 (0.73–1.03)

0.000

0.039

0.76 (0.57–1.02)

0.000

0.039

0.82 (0.63–1.07)

0.000

0.039

 HWE

0.98 (0.82–1.16)

0.000

0.786

0.98 (0.72–1.33)

0.000

0.905

0.99 (0.76–1.29)

0.000

0.962

 Ethnicity

         

  Asian

0.82 (0.61–1.11)

0.000

0.208

0.45 (0.24–0.85)

0.000

0.014

0.48 (0.27–0.86)

0.000

0.014

  Caucasian

0.93 (0.72–1.20)

0.000

0.569

0.94 (0.74–1.19)

0.043

0.595

0.98 (0.89–1.10)

0.513

0.778

  Mixed

0.94 (0.53–1.67)

0.000

0.833

1.25 (0.30–5.19)

0.000

0.759

1.38 (0.35–5.54)

0.000

0.645

  African

0.71 (0.23–2.13)

0.003

0.536

0.99 (0.15–6.34)

0.002

0.991

1.22 (0.22–6.67)

0.000

0.818

 SOC

         

  HB

0.85 (0.66–1.10)

0.000

0.227

0.61 (0.41–0.90)

0.000

0.014

0.64 (0.46–0.90)

0.000

0.011

  PB

0.92 (0.73–1.14)

0.001

0.430

1.08 (0.68–1.71)

0.000

0.751

1.21 (0.79–1.85)

0.000

0.373

 Ethnicity (with HWE)

         

  Asian

0.82 (0.56–1.20)

0.002

0.303

0.62 (0.28–1.38)

0.000

0.241

0.72 (0.38–1.35)

0.004

0.305

  Caucasian

1.13 (0.89–1.44)

0.000

0.316

1.01 (0.80–1.28)

0.098

0.918

1.00 (0.90–1.12)

0.495

0.979

  Mixed

0.94 (0.53–1.67)

0.000

0.833

1.25 (0.30–5.19)

0.000

0.759

1.38 (0.35–5.54)

0.000

0.645

SOC (with HWE)

         

  HB

1.01 (0.75–1.37)

0.000

0.932

0.85 (0.53–1.36)

0.000

0.493

0.85 (0.60–1.21)

0.026

0.369

  PB

0.96 (0.77–1.18)

0.003

0.677

1.13 (0.72–1.79)

0.000

0.590

0.99 (0.78–1.80)

0.000

0.426

T1DM

         

 Total

1.32 (0.99–1.76)

0.000

0.060

1.40 (0.90–2.18)

0.000

0.134

1.12 (0.83–1.50)

0.005

0.463

 HWE

1.25 (0.94–1.67)

0.000

0.131

1.27 (0.78–2.05)

0.000

0.331

1.04 (0.74–1.45)

0.014

0.839

 Ethnicity

         

  Caucasian

1.30 (0.83–2.01)

0.000

0.249

1.31 (0.67–1.92)

0.000

0.645

0.93 (0.69–1.23)

0.024

0.598

  Mixed

1.43 (1.07–1.90)

0.724

0.015

2.45 (1.18–5.07)

0.486

0.016

2.20 (1.08–4.48)

0.487

0.031

 SOC

         

  HB

1.51 (1.15–1.98)

0.337

0.003

1.77 (1.14–2.74)

0.128

0.010

1.16 (0.57–2.35)

0.066

 

  PB

1.27 (0.86–1.86)

0.000

0.229

1.33 (0.77–2.32)

0.000

0.312

1.10 (0.77–1.57)

0.013

0.611

 Ethnicity (with HWE)

         

  Caucasian

1.15 (0.74–1.78)

0.00

0.540

0.99 (0.56–1.75)

0.000

0.968

0.88 (0.61–1.25)

0.018

0.465

  Mixed

1.43 (1.07–1.90)

0.724

0.015

2.45 (1.18–5.07)

0.486

0.016

2.20 (1.08–4.48)

0.487

0.031

SOC (with HWE)

         

  HB

1.51 (1.15–1.98)

0.337

0.003

1.77 (1.14–2.74)

0.128

0.010

1.16 (0.57–2.35)

0.066

0.680

  PB

1.14 (0.78–1.68)

0.000

0.494

1.11 (0.59–2.10)

0.001

0.746

0.97 (0.62–1.50)

0.041

0.887

  1. Ph value of Q-test for heterogeneity test; P Z-test for the statistical significance of the OR; SOC source of control, HB hospital-based, PB population-based