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Table 3 Stratified analyses of IL-6 rs1800795 polymorphism and T2DM and T1DM risk

From: IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis

Variables N0. Case/ C-allele vs. G-allele CG vs. GG
Control OR(95%CI) Ph P OR (95% CI) Ph P
T2DM         
 Total 34 7257/15598 0.88 (0.76–1.01) 0.000 0.075 0.91 (0.77–1.08) 0.000 0.281
 HWE 25 5927/14023 0.98 (0.84–1.15) 0.000 0.832 0.97 (0.83–1.13) 0.000 0.687
 Ethnicity         
  Asian 14 2595/2208 0.76 (0.58–0.99) 0.000 0.039 0.99 (0.73–1.32) 0.002 0.925
  Caucasian 12 3767/12090 0.96 (0.81–1.12) 0.000 0.579 0.95 (0.73–1.22) 0.000 0.683
  Mixed 5 582/846 1.09 (0.55–2.19) 0.000 0.804 0.74 (0.58–0.94) 0.154 0.014
  African 3 313/454 0.83 (0.37–1.89) 0.000 0.665 0.91 (0.77–1.08) 0.041 0.486
 SOC         
  HB 23 3546/9186 0.83 (0.68–1.01) 0.000 0.059 0.95 (0.73–1.23) 0.000 0.706
  PB 11 3711/6412 0.98 (0.79–1.22) 0.000 0.874 0.89 (0.75–1.05) 0.100 0.166
 Ethnicity (with HWE)         
  Asian 10 1887/1922 0.83 (0.59–1.17) 0.000 0.283 0.97 (0.81–1.17) 0.115 0.778
  Caucasian 9 3458/11255 1.06 (0.91–1.25) 0.001 0.443 1.15 (0.90–1.47) 0.001 0.257
  Mixed 5 582/846 1.09 (0.55–2.19) 0.000 0.804 0.74 (0.58–0.94) 0.154 0.014
SOC (with HWE)         
  HB 16 2325/7749 0.97 (0.76–1.24) 0.000 0.788 1.07 (0.82–1.39) 0.001 0.635
  PB 9 3602/6274 1.01 (0.81–1.26) 0.000 0.907 0.90 (0.76–1.07) 0.086 0.221
T1DM         
 Total 12 10,264/9031 1.17 (0.96–1.42) 0.000 0.120 1.32 (1.01–1.74) 0.000 0.043
 HWE 10 10,004/8763 1.13 (0.91–1.41) 0.000 0.268 1.24 (0.96–1.61) 0.002 0.100
 Ethnicity         
  Caucasian 7 9737/8462 1.06 (0.81–1.38) 0.000 0.682 1.37 (0.90–2.11) 0.000 0.146
  Mixed 3 406/405 1.39 (1.10–1.77) 0.497 0.006 1.33 (0.99–1.79) 0.835 0.059
 SOC         
  HB 4 497/510 1.29 (1.07–1.56) 0.122 0.009 1.47 (1.11–1.94) 0.428 0.008
  PB 8 9767/8521 1.15 (0.89–1.48) 0.000 0.276 1.27 (0.88–1.82) 0.000 0.195
 Ethnicity (with HWE)         
  Caucasian 6 9527/8292 0.99 (0.74–1.34) 0.000 0.971 1.21 (0.80–1.82) 0.001 0.368
  Mixed 3 406/405 1.39 (1.10–1.77) 0.497 0.006 1.33 (0.99–1.79) 0.835 0.059
SOC (with HWE)         
  HB 4 497/510 1.29 (1.07–1.56) 0.122 0.009 1.47 (1.11–1.94) 0.428 0.008
  PB 6 9507/8253 1.09 (0.80–1.49) 0.000 0.578 1.13 (0.81–1.58) 0.010 0.460
Variables CC + CG vs. GG CC vs. GG CC vs. CG + GG
OR (95% CI) Ph P OR (95% CI) Ph P OR (95% CI) Ph P
T2DM          
 Total 0.87 (0.73–1.03) 0.000 0.039 0.76 (0.57–1.02) 0.000 0.039 0.82 (0.63–1.07) 0.000 0.039
 HWE 0.98 (0.82–1.16) 0.000 0.786 0.98 (0.72–1.33) 0.000 0.905 0.99 (0.76–1.29) 0.000 0.962
 Ethnicity          
  Asian 0.82 (0.61–1.11) 0.000 0.208 0.45 (0.24–0.85) 0.000 0.014 0.48 (0.27–0.86) 0.000 0.014
  Caucasian 0.93 (0.72–1.20) 0.000 0.569 0.94 (0.74–1.19) 0.043 0.595 0.98 (0.89–1.10) 0.513 0.778
  Mixed 0.94 (0.53–1.67) 0.000 0.833 1.25 (0.30–5.19) 0.000 0.759 1.38 (0.35–5.54) 0.000 0.645
  African 0.71 (0.23–2.13) 0.003 0.536 0.99 (0.15–6.34) 0.002 0.991 1.22 (0.22–6.67) 0.000 0.818
 SOC          
  HB 0.85 (0.66–1.10) 0.000 0.227 0.61 (0.41–0.90) 0.000 0.014 0.64 (0.46–0.90) 0.000 0.011
  PB 0.92 (0.73–1.14) 0.001 0.430 1.08 (0.68–1.71) 0.000 0.751 1.21 (0.79–1.85) 0.000 0.373
 Ethnicity (with HWE)          
  Asian 0.82 (0.56–1.20) 0.002 0.303 0.62 (0.28–1.38) 0.000 0.241 0.72 (0.38–1.35) 0.004 0.305
  Caucasian 1.13 (0.89–1.44) 0.000 0.316 1.01 (0.80–1.28) 0.098 0.918 1.00 (0.90–1.12) 0.495 0.979
  Mixed 0.94 (0.53–1.67) 0.000 0.833 1.25 (0.30–5.19) 0.000 0.759 1.38 (0.35–5.54) 0.000 0.645
SOC (with HWE)          
  HB 1.01 (0.75–1.37) 0.000 0.932 0.85 (0.53–1.36) 0.000 0.493 0.85 (0.60–1.21) 0.026 0.369
  PB 0.96 (0.77–1.18) 0.003 0.677 1.13 (0.72–1.79) 0.000 0.590 0.99 (0.78–1.80) 0.000 0.426
T1DM          
 Total 1.32 (0.99–1.76) 0.000 0.060 1.40 (0.90–2.18) 0.000 0.134 1.12 (0.83–1.50) 0.005 0.463
 HWE 1.25 (0.94–1.67) 0.000 0.131 1.27 (0.78–2.05) 0.000 0.331 1.04 (0.74–1.45) 0.014 0.839
 Ethnicity          
  Caucasian 1.30 (0.83–2.01) 0.000 0.249 1.31 (0.67–1.92) 0.000 0.645 0.93 (0.69–1.23) 0.024 0.598
  Mixed 1.43 (1.07–1.90) 0.724 0.015 2.45 (1.18–5.07) 0.486 0.016 2.20 (1.08–4.48) 0.487 0.031
 SOC          
  HB 1.51 (1.15–1.98) 0.337 0.003 1.77 (1.14–2.74) 0.128 0.010 1.16 (0.57–2.35) 0.066  
  PB 1.27 (0.86–1.86) 0.000 0.229 1.33 (0.77–2.32) 0.000 0.312 1.10 (0.77–1.57) 0.013 0.611
 Ethnicity (with HWE)          
  Caucasian 1.15 (0.74–1.78) 0.00 0.540 0.99 (0.56–1.75) 0.000 0.968 0.88 (0.61–1.25) 0.018 0.465
  Mixed 1.43 (1.07–1.90) 0.724 0.015 2.45 (1.18–5.07) 0.486 0.016 2.20 (1.08–4.48) 0.487 0.031
SOC (with HWE)          
  HB 1.51 (1.15–1.98) 0.337 0.003 1.77 (1.14–2.74) 0.128 0.010 1.16 (0.57–2.35) 0.066 0.680
  PB 1.14 (0.78–1.68) 0.000 0.494 1.11 (0.59–2.10) 0.001 0.746 0.97 (0.62–1.50) 0.041 0.887
  1. Ph value of Q-test for heterogeneity test; P Z-test for the statistical significance of the OR; SOC source of control, HB hospital-based, PB population-based