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Table 1 Comparison between before and after DPP4i treatment

From: Dipeptidyl peptidase 4 inhibitor improves insulin resistance in Japanese patients with type 2 diabetes: a single-arm study, a brief report

Parameters

Before

After

p value

Body weight (kg)

70.0 ± 12.6

67.8 ± 12.5

 < 0.05

BMI (kg/m2)

26.3 ± 4.8

25.3 ± 4.4

 < 0.05

eGFR

65.9 ± 12.8

64.2 ± 13.8

NS

AST (U/L)

28.1 ± 12.7

20.5 ± 3.8

NS

ALT (U/L)

43.4 ± 25.9

23.0 ± 6.8

 < 0.05

Gamma GTP (U/L)

46.1 ± 27.4

34.5 ± 11.7

NS

HbA1c (%)

7.8 ± 0.8

6.5 ± 0.7

 < 0.005

HbA1c (mmol/mol)

61 ± 9

47 ± 8

 < 0.005

Insulin secretion

 Fasting Plasma Glucose (mmol/L)

7.10 ± 0.70

6.22 ± 1.02

 < 0.05

 Glucose AUC (0–120 min)

21.6 ± 3.0

18.3 ± 4.1

 < 0.05

 Insulin AUC (0–120 min)

550.3 ± 387.7

496.7 ± 256.1

NS

 HOMA-beta (%)

63.8 ± 42.2

79.8 ± 59.3

NS

 Insulinogenic Index

1.00 ± 1.50

0.76 ± 0.68

NS

Insulin resistance

 HOMA-IR

3.8 ± 3.1

2.44 ± 1.19

NS

 GDR (mg/kg/min)

4.30 ± 1.2

6.24 ± 1.35

< 0.01

Incretins

 GLP-1 AUC

5.2 ± 1.9

12.6 ± 4.3

< 0.001

 GIP AUC

128.2 ± 47.1

180.1 ± 29.3

< 0.01

 Glucagon AUC

251.9 ± 67.6

234.4 ± 51.3

NS

 Adiponectin

5.0 ± 3.2

5.2 ± 3.2

NS

Body composition

 Percent body fat (%)

26.5 ± 9.0

24.4 ± 7.4

< 0.05

 Body fat mass (kg)

18.8 ± 8.9

16.9 ± 7.4

< 0.05

 Lean body mass (kg)

50.0 ± 8.8

49.8 ± 8.7

NS

 Skeletal muscle mass (kg)

47.3 ± 8.4

47.2 ± 8.3

NS

  1. Data are presented as the mean ± standard deviation
  2. The comparison of parameters between before and after treatment was performed using the Mann–Whitney U test