Parameters | Before | After | p value |
---|---|---|---|
Body weight (kg) | 70.0 ± 12.6 | 67.8 ± 12.5 | < 0.05 |
BMI (kg/m2) | 26.3 ± 4.8 | 25.3 ± 4.4 | < 0.05 |
eGFR | 65.9 ± 12.8 | 64.2 ± 13.8 | NS |
AST (U/L) | 28.1 ± 12.7 | 20.5 ± 3.8 | NS |
ALT (U/L) | 43.4 ± 25.9 | 23.0 ± 6.8 | < 0.05 |
Gamma GTP (U/L) | 46.1 ± 27.4 | 34.5 ± 11.7 | NS |
HbA1c (%) | 7.8 ± 0.8 | 6.5 ± 0.7 | < 0.005 |
HbA1c (mmol/mol) | 61 ± 9 | 47 ± 8 | < 0.005 |
Insulin secretion | |||
Fasting Plasma Glucose (mmol/L) | 7.10 ± 0.70 | 6.22 ± 1.02 | < 0.05 |
Glucose AUC (0–120 min) | 21.6 ± 3.0 | 18.3 ± 4.1 | < 0.05 |
Insulin AUC (0–120 min) | 550.3 ± 387.7 | 496.7 ± 256.1 | NS |
HOMA-beta (%) | 63.8 ± 42.2 | 79.8 ± 59.3 | NS |
Insulinogenic Index | 1.00 ± 1.50 | 0.76 ± 0.68 | NS |
Insulin resistance | |||
HOMA-IR | 3.8 ± 3.1 | 2.44 ± 1.19 | NS |
GDR (mg/kg/min) | 4.30 ± 1.2 | 6.24 ± 1.35 | < 0.01 |
Incretins | |||
GLP-1 AUC | 5.2 ± 1.9 | 12.6 ± 4.3 | < 0.001 |
GIP AUC | 128.2 ± 47.1 | 180.1 ± 29.3 | < 0.01 |
Glucagon AUC | 251.9 ± 67.6 | 234.4 ± 51.3 | NS |
Adiponectin | 5.0 ± 3.2 | 5.2 ± 3.2 | NS |
Body composition | |||
Percent body fat (%) | 26.5 ± 9.0 | 24.4 ± 7.4 | < 0.05 |
Body fat mass (kg) | 18.8 ± 8.9 | 16.9 ± 7.4 | < 0.05 |
Lean body mass (kg) | 50.0 ± 8.8 | 49.8 ± 8.7 | NS |
Skeletal muscle mass (kg) | 47.3 ± 8.4 | 47.2 ± 8.3 | NS |