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Table 2 The MR estimates of the causal effect of central obesity on BMD

From: The relationship between central obesity and bone mineral density: a Mendelian randomization study

Central obesity traits

IVW method

MR-Egger

Weighted median

Beta*

95% CI

P-value

Beta*

95% CI

P-value

Beta*

95% CI

P-value

WC

0.150

(0.073, 0.227)

1.3 × 10− 4

0.383

(0.190,0.575)

3 × 10–4

0.235

(0.184, 0.286)

1 × 10–7

WCadjBMI

− 0.005

(− 0.130, 0.119)

0.930

0.018

(− 0.497, 0.534)

0.944

− 0.062

(− 0.123,− 0.001)

0.046

HC

0.061

(− 0.019, 0.141)

0.133

0.397

(0.174, 0.621)

0.001

0.167

(0.109, 0.225)

1 × 10–7

HCadjBMI

− 0.135

(− 0.216, − 0.054)

0.001

− 0.076

(− 0.379, 0.226)

0.622

− 0.118

(− 0.173, − 0.063)

1 × 10–7

WHR

0.194

(0.062, 0.325)

0.004

0.491

(− 0.113, 1.096)

0.123

0.081

(− 0.009, 0.171)

0.077

WHRadjBMI

0.209

(0.046, 0.372)

0.012

1.040

(0.358, 1.721)

0.005

0.026

(− 0.040, 0.092)

0.438

  1. *Beta: a ratio of changes in standard deviations of BMD to that of central obesity traits