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Table 3 The association between genotic risk scores and indexs of islet function

From: Lifestyle in adulthood can modify the causal relationship between BMI and islet function: using Mendelian randomization analysis

 

Beta

95% CI

t

P

HOMAβ

Model1

44.471

 2.522 ~ 91.463

1.856

0.064

 

Model2

47.416

 0.059 ~ 94.241

1.916

0.052

 

Model3

41.969

 4.698 ~ 88.635

1.764

0.078

 

Model4

10.296

 34.474 ~ 55.067

0.451

0.652

HOMAIR

Model1

0.126

 0.183 ~ 0.435

0.798

0.425

 

Model2

0.085

 0.222 ~ 0.393

0.545

0.586

 

Model3

0.035

 0.269 ~ 0.339

0.223

0.823

 

Model4

 0.117

 0.415 ~ 0.181

 0.767

0.443

IAI(× 10)

Model1

 0.04

 0.061 ~  0.018

3.633

 < 0.001

 

Model2

 0.036

 0.057 ~  0.015

3.346

 < 0.001

 

Model3

 0.03

 0.051 ~  0.01

 2.877

0.004

 

Model4

 0.012

 0.031 ~ 0.007

1.221

0.223

  1. Model1 unadjusted; Model2 adjusted sex, age; Model3 adjusted sex, age, SBP, DBP, drunking status; Model4 adjusted sex, age, SBP, DBP, drunking status, smoking status and BMI