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Table 4 Association of baseline and change in HbA1c with risk of incident hypertension

From: Associations of the baseline level and change in glycosylated hemoglobin A1c with incident hypertension in non-diabetic individuals: a 3-year cohort study

 

Odds ratio (95% CI) of tertiles

Odds ratio (95% CI) of continuous value

Tertile1

Tertile2

Tertile3

p value

per 1-SD increment

p value

Baseline HbA1c

     

Unadjusted

1 (ref)

1.322 (1.008–1.734)

1.555 (1.184–2.042)

0.011

1.186 (1.061–1.324)

0.003

Model 1

1 (ref)

1.165 (0.883–1.536)

1.250 (0.943–1.658)

0.291

1.090 (0.973–1.222)

0.138

Model 2

1 (ref)

1.157 (0.856–1.565)

1.109 (0.808–1.523)

0.632

1.011 (0.891–1.147)

0.866

Model 3

1 (ref)

1.155 (0.853–1.565)

1.073 (0.779–1.479)

0.644

0.998 (0.878–1.133)

0.971

Change in HbA1c

     

Unadjusted

1 (ref)

1.316 (0.999–1.732)

1.449 (1.116–1.881)

0.017

1.187 (1.075–1.310)

0.001

Model 1

1 (ref)

1.375 (1.041–1.817)

1.576 (1.209–2.053)

0.003

1.231 (1.114–1.361)

 < 0.001

Model 2

1 (ref)

1.505 (1.114–2.034)

1.686 (1.263–2.251)

0.001

1.242 (1.115–1.384)

 < 0.001

Model 3

1 (ref)

1.512 (1.117–2.047)

1.598 (1.193–2.140)

0.003

1.214 (1.088–1.354)

 < 0.001

Model 4

1 (ref)

1.551 (1.142–2.107)

1.690 (1.240–2.303)

0.002

1.242 (1.106–1.394)

 < 0.001

  1. Model 1: adjusted for age (continuous), sex, education level, current smoking, current alcohol consumption; Model 2: Model 1 + body mass index, fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and systolic blood pressure at baseline (all continuous); Model 3: Model 2 + change in body mass index (continuous); Model 4: Model 3 + HbA1c at baseline (continuous). CI confidence interval, HbA1c glycated hemoglobin A1c